P51146 (RAB4B_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-4B

Gene names

Name:

Rab4b

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein transport. Probably involved in vesicular traffic By similarity.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell membrane Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Ras-related protein Rab-4B		PRO_0000121101
Regions
	Nucleotide binding	15 – 23	9	GTP By similarity
	Nucleotide binding	63 – 67	5	GTP By similarity
	Nucleotide binding	121 – 124	4	GTP By similarity
	Nucleotide binding	151 – 153	3	GTP By similarity
	Motif	37 – 45	9	Effector region By similarity
Amino acid modifications
	Modified residue	213	1	Cysteine methyl ester By similarity
	Lipidation	211	1	S-geranylgeranyl cysteine By similarity
	Lipidation	213	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P51146 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 0C3D76DC328B0018	FASTA	213	23,629
	10 20 30 40 50 60 MAETYDFLFK FLVIGSAGTG KSCLLHQFIE NKFKQDSNHT IGVEFGSRVV NVGGKTVKLQ 70 80 90 100 110 120 IWDTAGQERF RSVTRSYYRG AAGALLVYDI TSRETYNSLA AWLTDARTLA SPNIVVILCG 130 140 150 160 170 180 NKKDLDPERE VTFLEASRFA QENELMFLET SALTGENVEE AFLKCARTIL NKIDSGELDP 190 200 210 ERMGSGIQYG DISLRQLRQP RSAQAVAPQP CGC

References

[1]	Schuermann A., Muehl-Zuerbes P., Lie C., Joost H.G. Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Heart muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X78605 mRNA. Translation: CAA55339.1.
IPI	IPI00199224.
PIR	S58279.
RefSeq	NP_059051.1. NM_017355.1.
UniGene	Rn.7181.
3D structure databases
ProteinModelPortal	P51146.
SMR	P51146. Positions 6-183.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000002052.
Proteomic databases
PaxDb	P51146.
PRIDE	P51146.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000002052; ENSRNOP00000002052; ENSRNOG00000001500.
GeneID	50866.
KEGG	rno:50866.
UCSC	RGD:620931. rat.
Organism-specific databases
CTD	53916.
RGD	620931. Rab4b.
Phylogenomic databases
eggNOG	COG1100.
GeneTree	ENSGT00690000101805.
HOGENOM	HOG000233968.
HOVERGEN	HBG009351.
InParanoid	P51146.
KO	K07880.
OMA	SPNIVIL.
OrthoDB	EOG4WM4VM.
Gene expression databases
ArrayExpress	P51146.
Genevestigator	P51146.
GermOnline	ENSRNOG00000001500. Rattus norvegicus.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	610586.

Entry information

Entry name

RAB4B_RAT

Accession

Primary (citable) accession number: P51146

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program