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P51146

- RAB4B_RAT

UniProt

P51146 - RAB4B_RAT

Protein

Ras-related protein Rab-4B

Gene

Rab4b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Protein transport. Probably involved in vesicular traffic By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 239GTPBy similarity
    Nucleotide bindingi63 – 675GTPBy similarity
    Nucleotide bindingi121 – 1244GTPBy similarity
    Nucleotide bindingi151 – 1533GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-4B
    Gene namesi
    Name:Rab4b
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi620931. Rab4b.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 213212Ras-related protein Rab-4BPRO_0000121101Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Lipidationi211 – 2111S-geranylgeranyl cysteineBy similarity
    Modified residuei213 – 2131Cysteine methyl esterBy similarity
    Lipidationi213 – 2131S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiP51146.
    PRIDEiP51146.

    Expressioni

    Gene expression databases

    GenevestigatoriP51146.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000002052.

    Structurei

    3D structure databases

    ProteinModelPortaliP51146.
    SMRiP51146. Positions 6-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi37 – 459Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00710000106651.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiP51146.
    KOiK07880.
    OMAiFKDHSQH.
    OrthoDBiEOG7QK0CV.
    PhylomeDBiP51146.
    TreeFamiTF300032.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51146-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAETYDFLFK FLVIGSAGTG KSCLLHQFIE NKFKQDSNHT IGVEFGSRVV    50
    NVGGKTVKLQ IWDTAGQERF RSVTRSYYRG AAGALLVYDI TSRETYNSLA 100
    AWLTDARTLA SPNIVVILCG NKKDLDPERE VTFLEASRFA QENELMFLET 150
    SALTGENVEE AFLKCARTIL NKIDSGELDP ERMGSGIQYG DISLRQLRQP 200
    RSAQAVAPQP CGC 213
    Length:213
    Mass (Da):23,629
    Last modified:October 1, 1996 - v1
    Checksum:i0C3D76DC328B0018
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78605 mRNA. Translation: CAA55339.1.
    PIRiS58279.
    RefSeqiNP_059051.1. NM_017355.1.
    XP_006228645.1. XM_006228583.1.
    XP_006228646.1. XM_006228584.1.
    UniGeneiRn.7181.

    Genome annotation databases

    EnsembliENSRNOT00000002052; ENSRNOP00000002052; ENSRNOG00000001500.
    GeneIDi50866.
    KEGGirno:50866.
    UCSCiRGD:620931. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78605 mRNA. Translation: CAA55339.1 .
    PIRi S58279.
    RefSeqi NP_059051.1. NM_017355.1.
    XP_006228645.1. XM_006228583.1.
    XP_006228646.1. XM_006228584.1.
    UniGenei Rn.7181.

    3D structure databases

    ProteinModelPortali P51146.
    SMRi P51146. Positions 6-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000002052.

    Proteomic databases

    PaxDbi P51146.
    PRIDEi P51146.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000002052 ; ENSRNOP00000002052 ; ENSRNOG00000001500 .
    GeneIDi 50866.
    KEGGi rno:50866.
    UCSCi RGD:620931. rat.

    Organism-specific databases

    CTDi 53916.
    RGDi 620931. Rab4b.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00710000106651.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi P51146.
    KOi K07880.
    OMAi FKDHSQH.
    OrthoDBi EOG7QK0CV.
    PhylomeDBi P51146.
    TreeFami TF300032.

    Miscellaneous databases

    NextBioi 610586.
    PROi P51146.

    Gene expression databases

    Genevestigatori P51146.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Schuermann A., Muehl-Zuerbes P., Lie C., Joost H.G.
      Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Heart muscle.

    Entry informationi

    Entry nameiRAB4B_RAT
    AccessioniPrimary (citable) accession number: P51146
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3