Segment polarity protein dishevelled homolog DVL-1

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Reviewed, UniProtKB/Swiss-Prot P51141 (DVL1_MOUSE)

Last modified February 9, 2010. Version 101. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Segment polarity protein dishevelled homolog DVL-1
      Short name=Dishevelled-1
Alternative name(s):
    DSH homolog 1

Gene names

Name:	Dvl1
Synonyms:	Dvl

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	695 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	May play a role in the signal transduction pathway mediated by multiple Wnt genes.
Subunit structure	Interacts with CXXC4 By similarity. Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts (via PDZ domain) with NXN. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 By similarity. Ref.4 Ref.5 Ref.6
Subcellular location	Cytoplasm Potential.
Tissue specificity	High levels are seen in the brain, testis and kidney, lower levels in the ovary, breast, muscle, liver and small intestine, and very low levels are seen in the spleen and thymus. A moderate level expression is seen in the heart.
Developmental stage	Is expressed throughout the embryonic central nervous system from presomite stages and in neuron-rich areas of the brain throughout postnatal development, as well as in many other tissues.
Post-translational modification	Ubiquitinated, leading to its subsequent degradation by the ubiquitin-proteasome. The interaction with INVS is required for ubiquitination By similarity.
Disruption phenotype	Mice display abnormalities in social behaviors and sensorimotor gating. Ref.3
Sequence similarities	Belongs to the DSH family. Contains 1 DEP domain. Contains 1 DIX domain. Contains 1 PDZ (DHR) domain.

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Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm
Molecular function	Developmental protein
PTM	Phosphoprotein Ubl conjugation
Technical term	3D-structure
Gene Ontology (GO)
Biological process	dendrite morphogenesis Inferred from mutant phenotype. Source: MGI intracellular signaling cascade Inferred from electronic annotation. Source: InterPro neuromuscular junction development Inferred from genetic interaction. Source: MGI neurotransmitter secretion Inferred from genetic interaction. Source: MGI receptor clustering Inferred from genetic interaction. Source: MGI
Cellular component	cytoplasmic membrane-bounded vesicle Inferred from direct assay. Source: MGI soluble fraction Non-traceable author statement. Source: UniProtKB synapse Inferred from direct assay. Source: MGI synaptosome Inferred from direct assay. Source: MGI
Molecular function	signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
Vangl1	Q80Z96	1	EBI-1538407,EBI-1750708
Vangl2	Q91ZD4	1	EBI-1538407,EBI-1750744

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 695

695

Segment polarity protein dishevelled homolog DVL-1

PRO_0000145743

Regions

Domain

1 – 85

DIX

Domain

251 – 323

PDZ

Domain

425 – 499

DEP

Compositional bias

390 – 393

Poly-Ser

Amino acid modifications

Modified residue

559

Phosphoserine Ref.7

Experimental info

Sequence conflict

122 – 125

Missing in AAA74049. Ref.2

Sequence conflict

211

T → N in AAA74049. Ref.2

Secondary structure

695

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P51141-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: A9FA449F95CF75F2
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FASTA

695

75,350

        10         20         30         40         50         60 
MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK SMDQDFGVVK 

        70         80         90        100        110        120 
EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT DLPPPLERTG GIGDSRPPSF 

       130        140        150        160        170        180 
QPNVASSRDG MDNETGTESM VSHRRERARR RNRDEAARTN GHPRGDRRRD LGLPPDSAST 

       190        200        210        220        230        240 
VLSSELESSS FIDSDEEDNT SRLSSSTEQS TSSRLVRKHK CRRRKQRLRQ TDRASSFSSI 

       250        260        270        280        290        300 
TDSTMSLNII TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM 

       310        320        330        340        350        360 
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTIP RADPVRPIDP 

       370        380        390        400        410        420 
AAWLSHTAAL TGALPRYGTS PCSSAITRTS SSSLTSSVPG APQLEEAPLT VKSDMSAIVR 

       430        440        450        460        470        480 
VMQLPDSGLE IRDRMWLKIT IANAVIGADV VDWLYTHVEG FKERREARKY ASSMLKHGFL 

       490        500        510        520        530        540 
RHTVNKITFS EQCYYVFGDL CSNLASLNLN SGSSGASDQD TLAPLPHPSV PWPLGQGYPY 

       550        560        570        580        590        600 
QYPGPPPCFP PAYQDPGFSC GSGSAGSQQS EGSKSSGSTR SSHRTPGREE RRATGAGGSG 

       610        620        630        640        650        660 
SESDHTVPSG SGSTGWWERP VSQLSRGSSP RSQASAVAPG LPPLHPLTKA YAVVGGPPGG 

       670        680        690 
PPVRELAAVP PELTGSRQSF QKAMGNPCEF FVDIM

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled." Sussman D.J., Klingensmith J., Salinas P., Adams P.S., Nusse R., Perrimon N. Dev. Biol. 166:73-86(1994) [PubMed: 7958461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Brain.
[2]	"Organization and promoter analysis of the mouse dishevelled-1 gene." Lijam N., Sussman D.J. Genome Res. 5:116-124(1995) [PubMed: 9132266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c.
[3]	"Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1." Lijam N., Paylor R., McDonald M.P., Crawley J.N., Deng C.-X., Herrup K., Stevens K.E., Maccaferri G., McBain C.J., Sussman D.J., Wynshaw-Boris A. Cell 90:895-905(1997) [PubMed: 9298901] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[4]	"BP75, bromodomain-containing M(r) 75,000 protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta." Kim S., Lee J., Park J., Chung J. Cancer Res. 63:4792-4795(2003) [PubMed: 12941796] [Abstract] Cited for: INTERACTION WITH BRD7.
[5]	"Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family." Torban E., Wang H.-J., Groulx N., Gros P. J. Biol. Chem. 279:52703-52713(2004) [PubMed: 15456783] [Abstract] Cited for: INTERACTION WITH VANGL1 AND VANGL2.
[6]	"The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled." Funato Y., Michiue T., Asashima M., Miki H. Nat. Cell Biol. 8:501-508(2006) [PubMed: 16604061] [Abstract] Cited for: INTERACTION WITH NXN.
[7]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-559, MASS SPECTROMETRY.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U10115 mRNA. Translation: AAA82175.1.
U28138 Genomic DNA. Translation: AAA74049.1.

IPI

IPI00119027.

RefSeq

NP_034221.3.

UniGene

Mm.3400

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1FSH	NMR	-	A	395-495	[»]
1MC7	NMR	-	A	251-345	[»]
2KAW	NMR	-	A	248-337	[»]

SMR

P51141. Positions 2-82, 406-499.

ModBase

Search...

Protein-protein interaction databases

IntAct

P51141. 7 interactions.

STRING

P51141.

PTM databases

PhosphoSite

P51141.

Proteomic databases

PRIDE

P51141.

Genome annotation databases

Ensembl

ENSMUST00000030948; ENSMUSP00000030948; ENSMUSG00000029071; Mus musculus. [Genome view]

GeneID

13542.

KEGG

mmu:13542.

Organism-specific databases

CTD

13542.

MGI

MGI:94941. Dvl1.

Phylogenomic databases

eggNOG

roNOG06551.

HOGENOM

HBG717800.

HOVERGEN

P51141.

InParanoid

P51141.

Gene expression databases

ArrayExpress

P51141.

Bgee

P51141.

CleanEx

MM_DVL1.

Genevestigator

P51141.

GermOnline

ENSMUSG00000029071. Mus musculus.

Family and domain databases

InterPro

IPR000591. DEP_dom.
IPR008339. Dishevell.
IPR003351. Dishevelled.
IPR008340. Dishevelled_1.
IPR001158. DIX.
IPR015506. Dsh.
IPR001478. PDZ/DHR/GLGF.
IPR011991. WHTH_trsnscrt_rep_DNA-bd.
[Graphical view]

Gene3D

G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.

PANTHER

PTHR10878:SF5. Dishevelled_1. 1 hit.
PTHR10878. Dsh. 1 hit.

Pfam

PF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]

PRINTS

PR01760. DISHEVELLED.
PR01761. DISHEVELLED1.

SMART

SM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]

PROSITE

PS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

284142.

SOURCE

Search...

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Entry information

Entry name

DVL1_MOUSE

Accession

Primary (citable) accession number: P51141
Secondary accession number(s): Q60868

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	February 9, 2010
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents