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Protein

Segment polarity protein dishevelled

Gene

dsh

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity.3 Publications

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • Notch binding Source: FlyBase
  • phosphatidic acid binding Source: FlyBase
  • protein domain specific binding Source: FlyBase

GO - Biological processi

  • axon extension Source: FlyBase
  • axon guidance Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • cell migration Source: FlyBase
  • compound eye morphogenesis Source: FlyBase
  • dorsal closure Source: FlyBase
  • dorsal closure, elongation of leading edge cells Source: FlyBase
  • epidermis morphogenesis Source: FlyBase
  • establishment of epithelial cell apical/basal polarity Source: FlyBase
  • establishment of epithelial cell planar polarity Source: FlyBase
  • establishment of imaginal disc-derived wing hair orientation Source: FlyBase
  • establishment of mitotic spindle orientation Source: FlyBase
  • establishment of ommatidial planar polarity Source: FlyBase
  • establishment of planar polarity Source: FlyBase
  • establishment of thoracic bristle planar orientation Source: FlyBase
  • establishment of tissue polarity Source: FlyBase
  • female gonad development Source: FlyBase
  • filopodium assembly Source: FlyBase
  • heart development Source: FlyBase
  • heart formation Source: FlyBase
  • imaginal disc-derived leg joint morphogenesis Source: FlyBase
  • imaginal disc-derived wing hair organization Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • intracellular signal transduction Source: InterPro
  • lamellipodium assembly Source: FlyBase
  • motor neuron axon guidance Source: FlyBase
  • negative regulation of heart induction by canonical Wnt signaling pathway Source: FlyBase
  • negative regulation of Notch signaling pathway Source: FlyBase
  • ommatidial rotation Source: FlyBase
  • oogenesis Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • positive regulation of axon extension Source: FlyBase
  • positive regulation of axon guidance Source: FlyBase
  • protein localization Source: FlyBase
  • R3/R4 cell fate commitment Source: FlyBase
  • regulation of actin filament bundle assembly Source: FlyBase
  • regulation of compound eye pigmentation Source: FlyBase
  • regulation of tube length, open tracheal system Source: FlyBase
  • retinal ganglion cell axon guidance Source: FlyBase
  • salivary gland morphogenesis Source: FlyBase
  • segment polarity determination Source: UniProtKB-KW
  • sensory organ development Source: FlyBase
  • somatic stem cell population maintenance Source: FlyBase
  • synaptic target inhibition Source: FlyBase
  • wing and notum subfield formation Source: FlyBase
  • Wnt signaling pathway Source: FlyBase
  • Wnt signaling pathway, planar cell polarity pathway Source: GO_Central

Keywordsi

Molecular functionDevelopmental protein, Segmentation polarity protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-DME-201681. TCF dependent signaling in response to WNT.
R-DME-201688. WNT mediated activation of DVL.
R-DME-2028269. Signaling by Hippo.
R-DME-4086400. PCP/CE pathway.
R-DME-4608870. Asymmetric localization of PCP proteins.
R-DME-4641258. Degradation of DVL.
R-DME-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.
R-DME-5663220. RHO GTPases Activate Formins.
SignaLinkiP51140.

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled
Gene namesi
Name:dsh
ORF Names:CG18361
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0000499. dsh.

Subcellular locationi

GO - Cellular componenti

  • adherens junction Source: FlyBase
  • cytoplasm Source: FlyBase
  • cytosol Source: GO_Central
  • nucleus Source: UniProtKB-SubCell
  • plasma membrane Source: FlyBase

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001457401 – 623Segment polarity protein dishevelledAdd BLAST623

Post-translational modificationi

Phosphorylated. Wg signaling generates the hyperphosphorylated active forms.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP51140.
PRIDEiP51140.

PTM databases

iPTMnetiP51140.

Expressioni

Tissue specificityi

Found in egg chambers of the ovary and ubiquitously throughout embryogenesis and in disks. Expression is not seen in salivary glands, muscles or ventral ganglia but is observed in brain lobes.

Developmental stagei

Expressed at high levels at 0-1 hour and from 5-17 hours. Also expressed at high levels in early pupae.1 Publication

Gene expression databases

BgeeiFBgn0000499.
GenevisibleiP51140. DM.

Interactioni

Subunit structurei

Interacts with nkd. This interaction may require zinc.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • Notch binding Source: FlyBase
  • protein domain specific binding Source: FlyBase

Protein-protein interaction databases

BioGridi58490. 81 interactors.
IntActiP51140. 17 interactors.
MINTiMINT-8291181.
STRINGi7227.FBpp0073310.

Structurei

3D structure databases

ProteinModelPortaliP51140.
SMRiP51140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 91DIXPROSITE-ProRule annotationAdd BLAST84
Domaini252 – 324PDZPROSITE-ProRule annotationAdd BLAST73
Domaini404 – 478DEPPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 623Interaction with nkdAdd BLAST458

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi119 – 146Poly-GlnAdd BLAST28
Compositional biasi154 – 159Poly-Gln6
Compositional biasi551 – 557Poly-Ser7
Compositional biasi599 – 608Poly-Gly10

Sequence similaritiesi

Belongs to the DSH family.Curated

Phylogenomic databases

eggNOGiKOG3571. Eukaryota.
ENOG410Y5G4. LUCA.
InParanoidiP51140.
KOiK02353.
OMAiTNQSDNC.
OrthoDBiEOG091G041O.
PhylomeDBiP51140.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR000591. DEP_dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR026542. Dsh.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF32. PTHR10878:SF32. 1 hit.
PfamiView protein in Pfam
PF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF00595. PDZ. 1 hit.
PRINTSiPR01760. DISHEVELLED.
SMARTiView protein in SMART
SM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.

Sequencei

Sequence statusi: Complete.

P51140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDADRGGGQE TKVIYHIDDE TTPYLVKIPI PSAQVTLRDF KLVLNKQNNN
60 70 80 90 100
YKYFFKSMDA DFGVVKEEIA DDSTILPCFN GRVVSWLVSA DGTNQSDNCS
110 120 130 140 150
ELPTSECELG MGLTNRKLQQ QQQQHQQQQQ QQQQQHQQQQ QQQQQQVQPV
160 170 180 190 200
QLAQQQQQQV LHHQKMMGNP LLQPPPLTYQ SASVLSSDLD STSLFGTESE
210 220 230 240 250
LTLDRDMTDY SSVQRLQVRK KPQRRKKRAP SMSRTSSYSS ITDSTMSLNI
260 270 280 290 300
ITVSINMEAV NFLGISIVGQ SNRGGDGGIY VGSIMKGGAV ALDGRIEPGD
310 320 330 340 350
MILQVNDVNF ENMTNDEAVR VLREVVQKPG PIKLVVAKCW DPNPKGYFTI
360 370 380 390 400
PRTEPVRPID PGAWVAHTQA LTSHDSIIAD IAEPIKERLD QNNLEEIVKA
410 420 430 440 450
MTKPDSGLEI RDRMWLKITI PNAFIGADAV NWVLENVEDV QDRREARRIV
460 470 480 490 500
SAMLRSNYIK HTVNKLTFSE QCYYVVNEER NPNLLGRGHL HPHQLPHGHG
510 520 530 540 550
GHALSHADTE SITSDIGPLP NPPIYMPYSA TYNPSHGYQP IQYGIAERHI
560 570 580 590 600
SSGSSSSDVL TSKDISASQS DITSVIHQAN QLTIAAHGSN KSSGSSNRGG
610 620
GGGGGGGGNN TNDQDVSVFN YVL
Length:623
Mass (Da):68,917
Last modified:June 21, 2005 - v2
Checksum:i0BA24ED350666CF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti276D → N in AAA20216 (PubMed:8149913).Curated1
Sequence conflicti565I → T in AAA16535 (PubMed:8288125).Curated1
Sequence conflicti619F → S in AAA16535 (PubMed:8288125).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02491 mRNA. Translation: AAA20216.1.
L26974 mRNA. Translation: AAA16535.1.
AE014298 Genomic DNA. Translation: AAF48033.1.
BT023781 mRNA. Translation: AAZ41790.1.
PIRiA49840.
RefSeqiNP_511118.2. NM_078563.3.
UniGeneiDm.2927.

Genome annotation databases

EnsemblMetazoaiFBtr0073454; FBpp0073310; FBgn0000499.
GeneIDi32078.
KEGGidme:Dmel_CG18361.
UCSCiCG18361-RA. d. melanogaster.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDSH_DROME
AccessioniPrimary (citable) accession number: P51140
Secondary accession number(s): Q494J5, Q9VYZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 21, 2005
Last modified: July 5, 2017
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families