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P51121

- GLNA_XENLA

UniProt

P51121 - GLNA_XENLA

Protein

Glutamine synthetase

Gene

glul

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner By similarity. May play an important role in the early stages of vertebrate neural development.By similarity

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.
    L-glutamate = 4-aminobutanoate + CO2.

    Cofactori

    Biotin.By similarity
    Magnesium or manganese.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC
    3. glutamate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Lyase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase (EC:6.3.1.2)
    Short name:
    GS
    Alternative name(s):
    Glutamate decarboxylase (EC:4.1.1.15)
    Glutamate--ammonia ligase
    Gene namesi
    Name:glul
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6256042. glul.

    Subcellular locationi

    Cytoplasm By similarity. Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Glutamine synthetasePRO_0000153146Add
    BLAST

    Expressioni

    Developmental stagei

    Up-regulated during early neural development. Maternally transmitted and abundantly expressed in neuroectoderm-derived tissues during the gastrula and neurula stages.

    Interactioni

    Subunit structurei

    Homooctamer and homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP51121.
    SMRiP51121. Positions 4-372.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Phylogenomic databases

    HOVERGENiHBG005847.
    KOiK01915.

    Family and domain databases

    Gene3Di3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    PROSITEiPS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51121-1 [UniParc]FASTAAdd to Basket

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    MSVSHSSRLN KGVREQYMKL PQGEKVQVTY VWIDGTGEGV RCKTRTLDQE    50
    PKTIDEIPEW NFDGSSTHQA EGSNSDMYLI PVQMFRDPFC LDPNKLVMCE 100
    VLKYNRKSAE TNLRHTCKKI MEMVNDHRPW FGMEQEYTLL GINGHPYGWP 150
    ENGFPGPQGP YYCGVGADKV YGRDVVESHY KACLYAGIKI CGTNAEVMPS 200
    QWEFQVGPCE GIDMGDHLWM ARFILHRVCE DFGVVATLDP KPMTGNWNGA 250
    GCHTNYSTES MRVEGGLKHI EDAIEKLGKR HDYHICVYDP RGGKDNSRRL 300
    TGQHETSSIH EFSAGVANRG ASIRIPRQVG QEGYGYFEDR RPAANCDPYA 350
    VTEALVRTTI LNETGSETKD YKNGAGFSRA IGMASPRDAA VF 392
    Length:392
    Mass (Da):43,985
    Last modified:October 1, 1996 - v1
    Checksum:iD69C175E95FA8D2F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50062 mRNA. Translation: BAA08779.1.
    PIRiI51422.
    RefSeqiNP_001082548.1. NM_001089079.1.
    UniGeneiXl.47270.

    Genome annotation databases

    GeneIDi398556.
    KEGGixla:398556.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50062 mRNA. Translation: BAA08779.1 .
    PIRi I51422.
    RefSeqi NP_001082548.1. NM_001089079.1.
    UniGenei Xl.47270.

    3D structure databases

    ProteinModelPortali P51121.
    SMRi P51121. Positions 4-372.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 398556.
    KEGGi xla:398556.

    Organism-specific databases

    CTDi 398556.
    Xenbasei XB-GENE-6256042. glul.

    Phylogenomic databases

    HOVERGENi HBG005847.
    KOi K01915.

    Family and domain databases

    Gene3Di 3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    PROSITEi PS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a Xenopus glutamine synthetase gene abundantly expressed in the embryonic nervous system but not in adult brain."
      Hatada S., Kinoshita M., Noda M., Asashima M.
      FEBS Lett. 371:287-292(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGLNA_XENLA
    AccessioniPrimary (citable) accession number: P51121
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3