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Protein

Fragile X mental retardation syndrome-related protein 2

Gene

FXR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein.

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • RNA binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129245-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fragile X mental retardation syndrome-related protein 2
Gene namesi
Name:FXR2
Synonyms:FMR1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:4024. FXR2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: CACAO
  • cytosolic large ribosomal subunit Source: ProtInc
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleus Source: GO_Central
  • polysome Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi9513.
OpenTargetsiENSG00000129245.
PharmGKBiPA28440.

Polymorphism and mutation databases

BioMutaiFXR2.
DMDMi90177782.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501101 – 673Fragile X mental retardation syndrome-related protein 2Add BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphotyrosineBy similarity1
Modified residuei192PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei411PhosphothreonineCombined sources1
Modified residuei450PhosphoserineBy similarity1
Modified residuei453PhosphoserineCombined sources1
Modified residuei533PhosphoserineCombined sources1
Modified residuei566PhosphoserineCombined sources1
Modified residuei580PhosphoserineCombined sources1
Modified residuei598PhosphothreonineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP51116.
MaxQBiP51116.
PaxDbiP51116.
PeptideAtlasiP51116.
PRIDEiP51116.

PTM databases

iPTMnetiP51116.
PhosphoSitePlusiP51116.
SwissPalmiP51116.

Expressioni

Gene expression databases

BgeeiENSG00000129245.
CleanExiHS_FXR2.
ExpressionAtlasiP51116. baseline and differential.
GenevisibleiP51116. HS.

Organism-specific databases

HPAiCAB011205.
HPA022997.

Interactioni

Subunit structurei

Interacts with FMR1 (PubMed:7489725, PubMed:8668200, PubMed:11157796). Interacts with FXR1 (PubMed:7489725). Interacts with TDRD3 (PubMed:18664458). Interacts with CYFIP2 but not with CYFIP1 (By similarity).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-740459,EBI-740459
AP1M1Q9BXS56EBI-740459,EBI-541426
ARL6IP1Q150413EBI-740459,EBI-714543
BAZ2BQ9UIF8-23EBI-740459,EBI-10321972
BYSLQ138955EBI-740459,EBI-358049
C10orf62Q5T6814EBI-740459,EBI-744052
CAMK2DQ135573EBI-740459,EBI-351018
CDKL3Q8IVW45EBI-740459,EBI-3919850
CEP44Q9C0F13EBI-740459,EBI-744115
CEP55D3DR373EBI-740459,EBI-10173536
FAM90A1Q86YD73EBI-740459,EBI-6658203
FMR1Q06787-83EBI-740459,EBI-10224470
HMBOX1Q6NT763EBI-740459,EBI-2549423
HMBOX1Q6NT76-23EBI-740459,EBI-10212206
LASP1Q148473EBI-740459,EBI-742828
LCMT1Q9UIC82EBI-740459,EBI-747632
LCP2Q130945EBI-740459,EBI-346946
LDOC1O957513EBI-740459,EBI-740738
MBIPQ9NS733EBI-740459,EBI-741953
MCRS1Q96EZ83EBI-740459,EBI-348259
MEAF6Q9HAF13EBI-740459,EBI-399266
MFAP1P550815EBI-740459,EBI-1048159
MIA3Q5JRA6-23EBI-740459,EBI-10244342
MMTAG2Q9BU765EBI-740459,EBI-742459
MORF4L1Q9UBU83EBI-740459,EBI-399246
MRPL43Q8N9833EBI-740459,EBI-1043145
NIF3L1Q9GZT83EBI-740459,EBI-740897
NT5C2P499023EBI-740459,EBI-742084
PAF1Q8N7H54EBI-740459,EBI-2607770
PAICSP222343EBI-740459,EBI-712261
PCBD1P614574EBI-740459,EBI-740475
PIM1P113093EBI-740459,EBI-696621
POM121Q96HA14EBI-740459,EBI-739990
PRAM1Q96QH23EBI-740459,EBI-2860740
RABAC1Q9UI143EBI-740459,EBI-712367
SCELO951713EBI-740459,EBI-7543896
SRPK2P783623EBI-740459,EBI-593303
SYT6Q5T7P8-25EBI-740459,EBI-10246152
SYTL4Q96C245EBI-740459,EBI-747142
TBC1D22BQ9NU193EBI-740459,EBI-8787464
YES1P079473EBI-740459,EBI-515331
ZBTB22O152093EBI-740459,EBI-723574
ZMAT2Q96NC05EBI-740459,EBI-2682299

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi114890. 131 interactors.
IntActiP51116. 114 interactors.
MINTiMINT-108243.
STRINGi9606.ENSP00000250113.

Structurei

Secondary structure

1673
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 19Combined sources5
Beta strandi25 – 33Combined sources9
Beta strandi35 – 42Combined sources8
Beta strandi50 – 53Combined sources4
Helixi54 – 56Combined sources3
Beta strandi74 – 79Combined sources6
Beta strandi88 – 98Combined sources11
Beta strandi101 – 106Combined sources6
Beta strandi115 – 117Combined sources3
Helixi119 – 121Combined sources3
Beta strandi122 – 124Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H8ZX-ray1.92A13-136[»]
ProteinModelPortaliP51116.
SMRiP51116.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51116.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 60Agenet-like 1PROSITE-ProRule annotationAdd BLAST47
Domaini73 – 125Agenet-like 2PROSITE-ProRule annotationAdd BLAST53
Domaini232 – 261KH 1PROSITE-ProRule annotationAdd BLAST30
Domaini295 – 324KH 2PROSITE-ProRule annotationAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi414 – 418Poly-Ser5
Compositional biasi544 – 552Poly-Arg9
Compositional biasi584 – 594Poly-ArgAdd BLAST11

Domaini

The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.1 Publication

Sequence similaritiesi

Belongs to the FMR1 family.Curated
Contains 2 Agenet-like domains.PROSITE-ProRule annotation
Contains 2 KH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF9J. Eukaryota.
ENOG410ZDJG. LUCA.
GeneTreeiENSGT00390000017033.
HOGENOMiHOG000293377.
HOVERGENiHBG005739.
InParanoidiP51116.
KOiK15516.
OMAiDGPSMTE.
OrthoDBiEOG091G08EZ.
PhylomeDBiP51116.
TreeFamiTF105427.

Family and domain databases

Gene3Di3.30.1370.10. 2 hits.
InterProiIPR008395. Agenet-like_dom.
IPR022034. FXMRP1_C_core.
IPR032172. FXR_C1.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF05641. Agenet. 1 hit.
PF12235. FXMRP1_C_core. 1 hit.
PF16096. FXR_C1. 1 hit.
PF00013. KH_1. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 2 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiPS51641. AGENET_LIKE. 2 hits.
PS50084. KH_TYPE_1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGLASGGDV EPGLPVEVRG SNGAFYKGFV KDVHEDSVTI FFENNWQSER
60 70 80 90 100
QIPFGDVRLP PPADYNKEIT EGDEVEVYSR ANEQEPCGWW LARVRMMKGD
110 120 130 140 150
FYVIEYAACD ATYNEIVTLE RLRPVNPNPL ATKGSFFKVT MAVPEDLREA
160 170 180 190 200
CSNENVHKEF KKALGANCIF LNITNSELFI LSTTEAPVKR ASLLGDMHFR
210 220 230 240 250
SLRTKLLLMS RNEEATKHLE TSKQLAAAFQ EEFTVREDLM GLAIGTHGAN
260 270 280 290 300
IQQARKVPGV TAIELGEETC TFRIYGETPE ACRQARSYLE FSEDSVQVPR
310 320 330 340 350
NLVGKVIGKN GKVIQEIVDK SGVVRVRVEG DNDKKNPREE GMVPFIFVGT
360 370 380 390 400
RENISNAQAL LEYHLSYLQE VEQLRLERLQ IDEQLRQIGL GFRPPGSGRG
410 420 430 440 450
SGGSDKAGYS TDESSSSSLH ATRTYGGSYG GRGRGRRTGG PAYGPSSDVS
460 470 480 490 500
TASETESEKR EEPNRAGPGD RDPPTRGEES RRRPTGGRGR GPPPAPRPTS
510 520 530 540 550
RYNSSSISSV LKDPDSNPYS LLDTSEPEPP VDSEPGEPPP ASARRRRSRR
560 570 580 590 600
RRTDEDRTVM DGGLESDGPN MTENGLEDES RPQRRNRSRR RRNRGNRTDG
610 620 630 640 650
SISGDRQPVT VADYISRAES QSRQRPPLER TKPSEDSLSG QKGDSVSKLP
660 670
KGPSENGELS APLELGSMVN GVS
Length:673
Mass (Da):74,223
Last modified:March 7, 2006 - v2
Checksum:iB8A498C3F634D41F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti625 – 626RP → SA in AAC50292 (PubMed:7489725).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067039252Q → H.1 PublicationCorresponds to variant rs17854734dbSNPEnsembl.1
Natural variantiVAR_055979591R → P.Corresponds to variant rs36013555dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31501 mRNA. Translation: AAC50292.1.
BT009817 mRNA. Translation: AAP88819.1.
AK313836 mRNA. Translation: BAG36569.1.
CH471108 Genomic DNA. Translation: EAW90154.1.
CH471108 Genomic DNA. Translation: EAW90155.1.
BC020090 mRNA. Translation: AAH20090.1.
BC051907 mRNA. Translation: AAH51907.1.
BC067272 mRNA. Translation: AAH67272.1.
AF044263 Genomic DNA. Translation: AAC03357.1.
CCDSiCCDS45604.1.
PIRiS60173.
RefSeqiNP_004851.2. NM_004860.3.
UniGeneiHs.52788.

Genome annotation databases

EnsembliENST00000250113; ENSP00000250113; ENSG00000129245.
GeneIDi9513.
KEGGihsa:9513.
UCSCiuc002gia.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31501 mRNA. Translation: AAC50292.1.
BT009817 mRNA. Translation: AAP88819.1.
AK313836 mRNA. Translation: BAG36569.1.
CH471108 Genomic DNA. Translation: EAW90154.1.
CH471108 Genomic DNA. Translation: EAW90155.1.
BC020090 mRNA. Translation: AAH20090.1.
BC051907 mRNA. Translation: AAH51907.1.
BC067272 mRNA. Translation: AAH67272.1.
AF044263 Genomic DNA. Translation: AAC03357.1.
CCDSiCCDS45604.1.
PIRiS60173.
RefSeqiNP_004851.2. NM_004860.3.
UniGeneiHs.52788.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H8ZX-ray1.92A13-136[»]
ProteinModelPortaliP51116.
SMRiP51116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114890. 131 interactors.
IntActiP51116. 114 interactors.
MINTiMINT-108243.
STRINGi9606.ENSP00000250113.

PTM databases

iPTMnetiP51116.
PhosphoSitePlusiP51116.
SwissPalmiP51116.

Polymorphism and mutation databases

BioMutaiFXR2.
DMDMi90177782.

Proteomic databases

EPDiP51116.
MaxQBiP51116.
PaxDbiP51116.
PeptideAtlasiP51116.
PRIDEiP51116.

Protocols and materials databases

DNASUi9513.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250113; ENSP00000250113; ENSG00000129245.
GeneIDi9513.
KEGGihsa:9513.
UCSCiuc002gia.3. human.

Organism-specific databases

CTDi9513.
DisGeNETi9513.
GeneCardsiFXR2.
HGNCiHGNC:4024. FXR2.
HPAiCAB011205.
HPA022997.
MIMi605339. gene.
neXtProtiNX_P51116.
OpenTargetsiENSG00000129245.
PharmGKBiPA28440.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF9J. Eukaryota.
ENOG410ZDJG. LUCA.
GeneTreeiENSGT00390000017033.
HOGENOMiHOG000293377.
HOVERGENiHBG005739.
InParanoidiP51116.
KOiK15516.
OMAiDGPSMTE.
OrthoDBiEOG091G08EZ.
PhylomeDBiP51116.
TreeFamiTF105427.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129245-MONOMER.

Miscellaneous databases

ChiTaRSiFXR2. human.
EvolutionaryTraceiP51116.
GeneWikiiFXR2.
GenomeRNAii9513.
PROiP51116.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129245.
CleanExiHS_FXR2.
ExpressionAtlasiP51116. baseline and differential.
GenevisibleiP51116. HS.

Family and domain databases

Gene3Di3.30.1370.10. 2 hits.
InterProiIPR008395. Agenet-like_dom.
IPR022034. FXMRP1_C_core.
IPR032172. FXR_C1.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF05641. Agenet. 1 hit.
PF12235. FXMRP1_C_core. 1 hit.
PF16096. FXR_C1. 1 hit.
PF00013. KH_1. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 2 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiPS51641. AGENET_LIKE. 2 hits.
PS50084. KH_TYPE_1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFXR2_HUMAN
AccessioniPrimary (citable) accession number: P51116
Secondary accession number(s): B2R9M2
, D3DTQ1, Q86V09, Q8WUM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.