Reviewed, UniProtKB/Swiss-Prot P51116 (FXR2_HUMAN)

Names and origin

Protein names

Recommended name:
    Fragile X mental retardation syndrome-related protein 2

Gene names

Name:	FXR2
Synonyms:	FMR1L2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	673 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	RNA-binding protein.
Subunit structure	Interacts with FMR1 and FXR1. Interacts with CYFIP2 but not with CYFIP1. Interacts with TDRD3. Ref.7
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the FMR1 family. Contains 2 KH domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Domain	Repeat
Ligand	RNA-binding
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	cytosolic large ribosomal subunit Traceable author statement. Source: ProtInc
Molecular function	RNA binding Ref.1 Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LCMT1	Q9UIC8	1	EBI-740459,EBI-747632
MED7	O43513	1	EBI-740459,EBI-394632

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 673	673	Fragile X mental retardation syndrome-related protein 2		PRO_0000050110
Regions
	Domain	232 – 261	30	KH 1
	Domain	295 – 324	30	KH 2
	Compositional bias	414 – 418	5	Poly-Ser
	Compositional bias	544 – 552	9	Poly-Arg
	Compositional bias	584 – 594	11	Poly-Arg
Amino acid modifications
	Modified residue	411	1	Phosphothreonine Ref.10
	Modified residue	453	1	Phosphoserine Ref.8
	Modified residue	455	1	Phosphothreonine Ref.8
	Modified residue	519	1	Phosphotyrosine Ref.5
	Modified residue	525	1	Phosphoserine Ref.10
	Modified residue	533	1	Phosphoserine Ref.10
	Modified residue	566	1	Phosphoserine Ref.10
	Modified residue	598	1	Phosphothreonine Ref.10 Ref.8
	Modified residue	601	1	Phosphoserine Ref.10 Ref.8 Ref.6 Ref.9
	Modified residue	603	1	Phosphoserine Ref.10 Ref.8 Ref.6 Ref.9
Natural variations
	Natural variant	591	1	R → P: dbSNP rs36013555.		VAR_055979
Experimental info
	Sequence conflict	625 – 626	2	RP → SA in AAC50292. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P51116-1 [UniParc]. Last modified March 7, 2006. Version 2. Checksum: B8A498C3F634D41F	FASTA	673	74,223
	10 20 30 40 50 60 MGGLASGGDV EPGLPVEVRG SNGAFYKGFV KDVHEDSVTI FFENNWQSER QIPFGDVRLP 70 80 90 100 110 120 PPADYNKEIT EGDEVEVYSR ANEQEPCGWW LARVRMMKGD FYVIEYAACD ATYNEIVTLE 130 140 150 160 170 180 RLRPVNPNPL ATKGSFFKVT MAVPEDLREA CSNENVHKEF KKALGANCIF LNITNSELFI 190 200 210 220 230 240 LSTTEAPVKR ASLLGDMHFR SLRTKLLLMS RNEEATKHLE TSKQLAAAFQ EEFTVREDLM 250 260 270 280 290 300 GLAIGTHGAN IQQARKVPGV TAIELGEETC TFRIYGETPE ACRQARSYLE FSEDSVQVPR 310 320 330 340 350 360 NLVGKVIGKN GKVIQEIVDK SGVVRVRVEG DNDKKNPREE GMVPFIFVGT RENISNAQAL 370 380 390 400 410 420 LEYHLSYLQE VEQLRLERLQ IDEQLRQIGL GFRPPGSGRG SGGSDKAGYS TDESSSSSLH 430 440 450 460 470 480 ATRTYGGSYG GRGRGRRTGG PAYGPSSDVS TASETESEKR EEPNRAGPGD RDPPTRGEES 490 500 510 520 530 540 RRRPTGGRGR GPPPAPRPTS RYNSSSISSV LKDPDSNPYS LLDTSEPEPP VDSEPGEPPP 550 560 570 580 590 600 ASARRRRSRR RRTDEDRTVM DGGLESDGPN MTENGLEDES RPQRRNRSRR RRNRGNRTDG 610 620 630 640 650 660 SISGDRQPVT VADYISRAES QSRQRPPLER TKPSEDSLSG QKGDSVSKLP KGPSENGELS 670 APLELGSMVN GVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2." Zhang Y., O'Connor J.P., Siomi M.C., Srinivasan S., Dutra A., Nussbaum R.L., Dreyfuss G. EMBO J. 14:5358-5366(1995) [PubMed: 7489725] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph and PNS.
[4]	"The rat androgen-binding protein (ABP/SHBG) gene contains triplet repeats similar to unstable triplets: evidence that the ABP/SHBG and the fragile X-related 2 genes overlap." Joseph D.R. Steroids 63:2-4(1998) [PubMed: 9437788] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
[5]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-519, MASS SPECTROMETRY.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601 AND SER-603, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP." Linder B., Ploettner O., Kroiss M., Hartmann E., Laggerbauer B., Meister G., Keidel E., Fischer U. Hum. Mol. Genet. 17:3236-3246(2008) [PubMed: 18664458] [Abstract] Cited for: INTERACTION WITH TDRD3.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-453; THR-455; THR-598; SER-601 AND SER-603, MASS SPECTROMETRY.
[9]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601 AND SER-603, MASS SPECTROMETRY.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-411; SER-525; SER-533; SER-566; THR-598; SER-601 AND SER-603, MASS SPECTROMETRY.
[11]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U31501 mRNA. Translation: AAC50292.1. BT009817 mRNA. Translation: AAP88819.1. BC067272 mRNA. Translation: AAH67272.1. BC020090 mRNA. Translation: AAH20090.1. AF044263 Genomic DNA. Translation: AAC03357.1.
IPI	IPI00016250.
PIR	S60173.
RefSeq	NP_004851.1.
UniGene	Hs.52788
3D structure databases
HSSP	HSSP built from PDB template 2FMR based on UniProtKB Q06787.
SMR	P51116. Positions 14-144, 222-299.
ModBase	Search...
Protein-protein interaction databases
IntAct	P51116. 51 interactions.
PTM databases
PhosphoSite	P51116.
Proteomic databases
PRIDE	P51116.
Genome annotation databases
Ensembl	ENSG00000129245. Homo sapiens. [Contig view]
GeneID	9513.
KEGG	hsa:9513.
Organism-specific databases
GeneCards	GC17M007435.
H-InvDB	HIX0013506.
HGNC	HGNC:4024. FXR2.
MIM	605339. gene.
PharmGKB	PA28440.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P51116.
HOVERGEN	P51116.
Gene expression databases
ArrayExpress	P51116.
Bgee	P51116.
CleanEx	HS_FXR2.
GermOnline	ENSG00000129245. Homo sapiens.
Family and domain databases
InterPro	IPR008395. Agenet. IPR004087. KH. IPR004088. KH_type_1. IPR018111. KH_type_1_subgr. [Graphical view]
Pfam	PF05641. Agenet. 1 hit. PF00013. KH_1. 2 hits. [Graphical view]
SMART	SM00322. KH. 2 hits. [Graphical view]
PROSITE	PS50084. KH_TYPE_1. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	35646.
SOURCE	Search...

Entry information

Entry name

FXR2_HUMAN

Accession

Primary (citable) accession number: P51116
Secondary accession number(s): Q8WUM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	March 7, 2006
Last modified:	May 26, 2009
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)