Reviewed,
UniProtKB/Swiss-Prot P51116 (FXR2_HUMAN)
Last modified
November 25, 2008.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Fragile X mental retardation syndrome-related protein 2 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 673 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | RNA-binding protein. |
| Subunit structure | Interacts with FMR1 and FXR1. Interacts with CYFIP2 but not with CYFIP1. |
| Subcellular location | |
| Sequence similarities | Belongs to the FMR1 family. Contains 2 KH domains. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Domain | Repeat |
| Ligand | RNA-binding |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Cellular component | cytosolic large ribosomal subunit Traceable author statement. Source: ProtInc |
| Molecular function | RNA binding Ref.1 Traceable author statement. Source: ProtInc protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| LCMT1 | Q9UIC8 | 1 | EBI-740459,EBI-747632 | |
| MED7 | O43513 | 1 | EBI-740459,EBI-394632 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 673 | 673 | Fragile X mental retardation syndrome-related protein 2 | PRO_0000050110 | |||||
Regions | |||||||||
| Domain | 232 – 261 | 30 | KH 1 | ||||||
| Domain | 295 – 324 | 30 | KH 2 | ||||||
| Compositional bias | 414 – 418 | 5 | Poly-Ser | ||||||
| Compositional bias | 544 – 552 | 9 | Poly-Arg | ||||||
| Compositional bias | 584 – 594 | 11 | Poly-Arg | ||||||
Amino acid modifications | |||||||||
| Modified residue | 411 | 1 | Phosphothreonine | ||||||
| Modified residue | 453 | 1 | Phosphoserine | ||||||
| Modified residue | 455 | 1 | Phosphothreonine | ||||||
| Modified residue | 519 | 1 | Phosphotyrosine | ||||||
| Modified residue | 525 | 1 | Phosphoserine | ||||||
| Modified residue | 533 | 1 | Phosphoserine | ||||||
| Modified residue | 566 | 1 | Phosphoserine | ||||||
| Modified residue | 598 | 1 | Phosphothreonine | ||||||
| Modified residue | 601 | 1 | Phosphoserine | ||||||
| Modified residue | 603 | 1 | Phosphoserine | ||||||
Experimental info | |||||||||
| Sequence conflict | 625 – 626 | 2 | RP → SA in AAC50292. Ref.1 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2." Zhang Y., O'Connor J.P., Siomi M.C., Srinivasan S., Dutra A., Nussbaum R.L., Dreyfuss G. EMBO J. 14:5358-5366(1995) [PubMed: 7489725] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph and PNS. |
| [4] | "The rat androgen-binding protein (ABP/SHBG) gene contains triplet repeats similar to unstable triplets: evidence that the ABP/SHBG and the fragile X-related 2 genes overlap." Joseph D.R. Steroids 63:2-4(1998) [PubMed: 9437788] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27. |
| [5] | "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-519, MASS SPECTROMETRY. |
| [6] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601 AND SER-603, MASS SPECTROMETRY. Tissue: Epithelium. |
| [7] | "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-453; THR-455; THR-598; SER-601 AND SER-603, MASS SPECTROMETRY. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-411; SER-525; SER-533; SER-566; THR-598; SER-601 AND SER-603, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| U31501 mRNA. Translation: AAC50292.1. BT009817 mRNA. Translation: AAP88819.1. BC067272 mRNA. Translation: AAH67272.1. BC020090 mRNA. Translation: AAH20090.1. AF044263 Genomic DNA. Translation: AAC03357.1. | |
| PIR | S60173. |
| RefSeq | NP_004851.1. |
| UniGene | Hs.52788 |
3D structure databases | |
| HSSP | HSSP built from PDB template 2FMR based on UniProtKB Q06787. |
| SMR | P51116. Positions 14-144, 222-299. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P51116. |
PTM databases | |
| PhosphoSite | P51116. |
Genome annotation databases | |
| Ensembl | ENSG00000129245. Homo sapiens. [Contig view] |
| GeneID | 9513. |
| KEGG | hsa:9513. |
Organism-specific databases | |
| H-InvDB | HIX0013506. |
| HGNC | HGNC:4024. FXR2. |
| HPA | CAB011205. |
| MIM | 605339. gene. |
| PharmGKB | PA28440. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P51116. |
| HOVERGEN | P51116. |
Gene expression databases | |
| ArrayExpress | P51116. |
| CleanEx | HS_FXR2. |
| GermOnline | ENSG00000129245. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR008395. Agenet. IPR004087. KH. IPR004088. KH_type_1. [Graphical view] |
| Pfam | PF05641. Agenet. 1 hit. PF00013. KH_1. 2 hits. [Graphical view] |
| SMART | SM00322. KH. 2 hits. [Graphical view] |
| PROSITE | PS50084. KH_TYPE_1. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 35646. |
| SOURCE | Search... |
Entry information
| Entry name | FXR2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P51116 Secondary accession number(s): Q8WUM2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


