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Protein

Fragile X mental retardation syndrome-related protein 2

Gene

FXR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein.

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • mRNA binding Source: GO_Central
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fragile X mental retardation syndrome-related protein 2
Gene namesi
Name:FXR2
Synonyms:FMR1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:4024. FXR2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: CACAO
  • cytosol Source: HPA
  • cytosolic large ribosomal subunit Source: ProtInc
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleus Source: GO_Central
  • polysome Source: GO_Central

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi9513.
OpenTargetsiENSG00000129245.
PharmGKBiPA28440.

Polymorphism and mutation databases

BioMutaiFXR2.
DMDMi90177782.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501101 – 673Fragile X mental retardation syndrome-related protein 2Add BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphotyrosineBy similarity1
Modified residuei192PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei411PhosphothreonineCombined sources1
Modified residuei450PhosphoserineBy similarity1
Modified residuei453PhosphoserineCombined sources1
Modified residuei533PhosphoserineCombined sources1
Modified residuei566PhosphoserineCombined sources1
Modified residuei580PhosphoserineCombined sources1
Modified residuei598PhosphothreonineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP51116.
MaxQBiP51116.
PaxDbiP51116.
PeptideAtlasiP51116.
PRIDEiP51116.

PTM databases

iPTMnetiP51116.
PhosphoSitePlusiP51116.
SwissPalmiP51116.

Expressioni

Gene expression databases

BgeeiENSG00000129245.
CleanExiHS_FXR2.
ExpressionAtlasiP51116. baseline and differential.
GenevisibleiP51116. HS.

Organism-specific databases

HPAiCAB011205.
HPA022997.

Interactioni

Subunit structurei

Interacts with FMR1 (PubMed:7489725, PubMed:8668200, PubMed:11157796). Interacts with FXR1 (PubMed:7489725). Interacts with TDRD3 (PubMed:18664458). Interacts with CYFIP2 but not with CYFIP1 (By similarity).By similarity4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi114890. 131 interactors.
IntActiP51116. 116 interactors.
MINTiMINT-108243.
STRINGi9606.ENSP00000250113.

Structurei

Secondary structure

1673
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 19Combined sources5
Beta strandi25 – 33Combined sources9
Beta strandi35 – 42Combined sources8
Beta strandi50 – 53Combined sources4
Helixi54 – 56Combined sources3
Beta strandi74 – 79Combined sources6
Beta strandi88 – 98Combined sources11
Beta strandi101 – 106Combined sources6
Beta strandi115 – 117Combined sources3
Helixi119 – 121Combined sources3
Beta strandi122 – 124Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H8ZX-ray1.92A13-136[»]
ProteinModelPortaliP51116.
SMRiP51116.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51116.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 60Agenet-like 1PROSITE-ProRule annotationAdd BLAST47
Domaini73 – 125Agenet-like 2PROSITE-ProRule annotationAdd BLAST53
Domaini232 – 261KH 1PROSITE-ProRule annotationAdd BLAST30
Domaini295 – 324KH 2PROSITE-ProRule annotationAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi414 – 418Poly-Ser5
Compositional biasi544 – 552Poly-Arg9
Compositional biasi584 – 594Poly-ArgAdd BLAST11

Domaini

The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.1 Publication

Sequence similaritiesi

Belongs to the FMR1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF9J. Eukaryota.
ENOG410ZDJG. LUCA.
GeneTreeiENSGT00390000017033.
HOGENOMiHOG000293377.
HOVERGENiHBG005739.
InParanoidiP51116.
KOiK15516.
OMAiHTTRTYG.
OrthoDBiEOG091G08EZ.
PhylomeDBiP51116.
TreeFamiTF105427.

Family and domain databases

Gene3Di3.30.1370.10. 2 hits.
InterProiView protein in InterPro
IPR008395. Agenet-like_dom.
IPR022034. FXMRP1_C_core.
IPR032172. FXR_C1.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
PfamiView protein in Pfam
PF05641. Agenet. 1 hit.
PF12235. FXMRP1_C_core. 1 hit.
PF16096. FXR_C1. 1 hit.
PF00013. KH_1. 2 hits.
SMARTiView protein in SMART
SM00322. KH. 2 hits.
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiView protein in PROSITE
PS51641. AGENET_LIKE. 2 hits.
PS50084. KH_TYPE_1. 2 hits.

Sequencei

Sequence statusi: Complete.

P51116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGLASGGDV EPGLPVEVRG SNGAFYKGFV KDVHEDSVTI FFENNWQSER
60 70 80 90 100
QIPFGDVRLP PPADYNKEIT EGDEVEVYSR ANEQEPCGWW LARVRMMKGD
110 120 130 140 150
FYVIEYAACD ATYNEIVTLE RLRPVNPNPL ATKGSFFKVT MAVPEDLREA
160 170 180 190 200
CSNENVHKEF KKALGANCIF LNITNSELFI LSTTEAPVKR ASLLGDMHFR
210 220 230 240 250
SLRTKLLLMS RNEEATKHLE TSKQLAAAFQ EEFTVREDLM GLAIGTHGAN
260 270 280 290 300
IQQARKVPGV TAIELGEETC TFRIYGETPE ACRQARSYLE FSEDSVQVPR
310 320 330 340 350
NLVGKVIGKN GKVIQEIVDK SGVVRVRVEG DNDKKNPREE GMVPFIFVGT
360 370 380 390 400
RENISNAQAL LEYHLSYLQE VEQLRLERLQ IDEQLRQIGL GFRPPGSGRG
410 420 430 440 450
SGGSDKAGYS TDESSSSSLH ATRTYGGSYG GRGRGRRTGG PAYGPSSDVS
460 470 480 490 500
TASETESEKR EEPNRAGPGD RDPPTRGEES RRRPTGGRGR GPPPAPRPTS
510 520 530 540 550
RYNSSSISSV LKDPDSNPYS LLDTSEPEPP VDSEPGEPPP ASARRRRSRR
560 570 580 590 600
RRTDEDRTVM DGGLESDGPN MTENGLEDES RPQRRNRSRR RRNRGNRTDG
610 620 630 640 650
SISGDRQPVT VADYISRAES QSRQRPPLER TKPSEDSLSG QKGDSVSKLP
660 670
KGPSENGELS APLELGSMVN GVS
Length:673
Mass (Da):74,223
Last modified:March 7, 2006 - v2
Checksum:iB8A498C3F634D41F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti625 – 626RP → SA in AAC50292 (PubMed:7489725).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067039252Q → H1 PublicationCorresponds to variant dbSNP:rs17854734Ensembl.1
Natural variantiVAR_055979591R → P. Corresponds to variant dbSNP:rs36013555Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31501 mRNA. Translation: AAC50292.1.
BT009817 mRNA. Translation: AAP88819.1.
AK313836 mRNA. Translation: BAG36569.1.
CH471108 Genomic DNA. Translation: EAW90154.1.
CH471108 Genomic DNA. Translation: EAW90155.1.
BC020090 mRNA. Translation: AAH20090.1.
BC051907 mRNA. Translation: AAH51907.1.
BC067272 mRNA. Translation: AAH67272.1.
AF044263 Genomic DNA. Translation: AAC03357.1.
CCDSiCCDS45604.1.
PIRiS60173.
RefSeqiNP_004851.2. NM_004860.3.
UniGeneiHs.52788.

Genome annotation databases

EnsembliENST00000250113; ENSP00000250113; ENSG00000129245.
GeneIDi9513.
KEGGihsa:9513.
UCSCiuc002gia.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFXR2_HUMAN
AccessioniPrimary (citable) accession number: P51116
Secondary accession number(s): B2R9M2
, D3DTQ1, Q86V09, Q8WUM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 7, 2006
Last modified: June 7, 2017
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families