P51111 (HD_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 94.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Huntingtin Alternative name(s): Huntington disease protein homolog Short name=HD protein homolog | ||||
| Gene names |
| ||||
| Organism | Rattus norvegicus (Rat) [Reference proteome] | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 3110 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | May play a role in microtubule-mediated transport or vesicle function. |
| Subunit structure | Interacts with PQBP1 and SETD2. Binds SH3GLB1 By similarity. Interacts with PFN1. Interacts with TPR; the interaction is inhibited by forms of Huntingtin with expanded polyglutamine stretch By similarity. |
| Subcellular location | Cytoplasm By similarity. Nucleus By similarity. Note: Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner. |
| Tissue specificity | Expressed to a high degree in all the regions of the brain of adults and in meiotic cells of the testis. In addition, very low levels are detected in various non-neuronal tissues (heart, muscle, liver, lung and kidney). |
| Developmental stage | Identified at high levels in neuronal tissues of embryos as early as day 14.5. This expression remains constant in all further development stages (up to the adult). On the other hand the expression in non-neuronal tissues is down-regulated from stage 17.5 day old embryos. |
| Domain | The N-terminal Gln-rich and Pro-rich domain has great conformational flexibility and is likely to exist in a fluctuating equilibrium of alpha-helical, random coil, and extended conformations By similarity. |
| Post-translational modification | Phosphorylation at Ser-1150 and Ser-1170 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. |
| Polymorphism | The poly-Gln region does not appear to be polymorphic, explaining the absence of a rodent HD-like disorder. |
| Sequence similarities | Belongs to the huntingtin family. Contains 5 HEAT repeats. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 3110 | 3110 | Huntingtin | PRO_0000083944 | |||||
Regions | |||||||||
| Repeat | 174 – 211 | 38 | HEAT 1 | ||||||
| Repeat | 216 – 253 | 38 | HEAT 2 | ||||||
| Repeat | 773 – 810 | 38 | HEAT 3 | ||||||
| Repeat | 873 – 911 | 39 | HEAT 4 | ||||||
| Repeat | 1395 – 1432 | 38 | HEAT 5 | ||||||
| Motif | 2363 – 2372 | 10 | Nuclear export signal By similarity | ||||||
| Compositional bias | 11 – 18 | 8 | Poly-Gln | ||||||
| Compositional bias | 19 – 38 | 20 | Poly-Pro | ||||||
| Compositional bias | 42 – 51 | 10 | Poly-Pro | ||||||
| Compositional bias | 1408 – 1411 | 4 | Poly-Thr | ||||||
| Compositional bias | 2606 – 2611 | 6 | Poly-Glu | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 146 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 204 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 313 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 389 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 402 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 412 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 1150 | 1 | Phosphoserine; by CDK5 By similarity | ||||||
| Modified residue | 1170 | 1 | Phosphoserine; by CDK5 By similarity | ||||||
| Modified residue | 1845 | 1 | Phosphoserine By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Expression of the Huntington disease gene in rodents: cloning the rat homologue and evidence for downregulation in non-neuronal tissues during development." Schmitt I., Baechner D., Megow D., Henklein P., Boulter J., Hameister H., Epplen J.T., Riess O. Hum. Mol. Genet. 4:1173-1182(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | Lubec G., Kang S.U., Lubec S. Submitted (SEP-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 356-384; 429-441; 767-795; 1760-1772; 1832-1838 AND 2875-2898, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Brain. |
| [3] | "Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues." Strong T.V., Tagle D.A., Valdes J.M., Elmer L.W., Boehm K., Swaroop M., Kaatz K.W., Collins F.S., Albin R.L. Nat. Genet. 5:259-265(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1773-1926. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U18650 mRNA. Translation: AAA90987.1. Sequence problems. U01022 mRNA. Translation: AAC52133.1. |
| IPI | IPI00949157. |
| PIR | S40522. |
| UniGene | Rn.11193. |
3D structure databases | |
| ProteinModelPortal | P51111. |
| ModBase | Search... |
Protein-protein interaction databases | |
| MINT | MINT-3375769. |
| STRING | 10116.ENSRNOP00000054971. |
PTM databases | |
| PhosphoSite | P51111. |
Proteomic databases | |
| PaxDb | P51111. |
| PRIDE | P51111. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Organism-specific databases | |
| RGD | 68337. Htt. |
Phylogenomic databases | |
| eggNOG | NOG82191. |
| HOGENOM | HOG000082472. |
| HOVERGEN | HBG005953. |
| InParanoid | P51111. |
| OrthoDB | EOG4RNB7G. |
Gene expression databases | |
| ArrayExpress | P51111. |
| Genevestigator | P51111. |
| GermOnline | ENSRNOG00000011073. Rattus norvegicus. |
Family and domain databases | |
| Gene3D | 1.25.10.10. 4 hits. |
| InterPro | IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000091. Huntingtin. IPR024613. Huntingtin_middle-repeat. [Graphical view] |
| PANTHER | PTHR10170. PTHR10170. 1 hit. |
| Pfam | PF12372. DUF3652. 2 hits. [Graphical view] |
| PRINTS | PR00375. HUNTINGTIN. |
| SUPFAM | SSF48371. ARM-type_fold. 2 hits. |
| PROSITE | PS50077. HEAT_REPEAT. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HD_RAT | ||||||||
| Accession | Primary (citable) accession number: P51111 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |