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P51110 (DFRA_VITVI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydroflavonol-4-reductase

Short name=DFR
EC=1.1.1.219
Alternative name(s):
Dihydrokaempferol 4-reductase
Gene names
Name:DFR
OrganismVitis vinifera (Grape)
Taxonomic identifier29760 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsVitalesVitaceaeVitis

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH.

Pathway

Pigment biosynthesis; anthocyanin biosynthesis.

Induction

By light.

Sequence similarities

Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   LigandNADP
   Molecular functionOxidoreductase
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processanthocyanin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

cellular metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

dihydrokaempferol 4-reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Dihydroflavonol-4-reductase
PRO_0000215572

Secondary structure

.......................................................... 337
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P51110 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 73EDB67A03DF94E9

FASTA33737,757
        10         20         30         40         50         60 
MGSQSETVCV TGASGFIGSW LVMRLLERRL TVRATVRDPT NVKKVKHLLD LPKAETHLTL 

        70         80         90        100        110        120 
WKADLADEGS FDEAIKGCTG VFHVATPMDF ESKDPENEVI KPTIEGMLGI MKSCAAAKTV 

       130        140        150        160        170        180 
RRLVFTSSAG TVNIQEHQLP VYDESCWSDM EFCRAKKMTA WMYFVSKTLA EQAAWKYAKE 

       190        200        210        220        230        240 
NNIDFITIIP TLVVGPFIMS SMPPSLITAL SPITGNEAHY SIIRQGQFVH LDDLCNAHIY 

       250        260        270        280        290        300 
LFENPKAEGR YICSSHDCII LDLAKMLREK YPEYNIPTEF KGVDENLKSV CFSSKKLTDL 

       310        320        330 
GFEFKYSLED MFTGAVDTCR AKGLLRPSHE KPVDGKT 

« Hide

References

[1]"Cloning and molecular analysis of structural genes involved in flavonoid and stilbene biosynthesis in grape (Vitis vinifera L.)."
Sparvoli F., Martin C., Scienza A., Gavazzi G., Tonelli C.
Plant Mol. Biol. 24:743-755(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Lambrusco Foglia Frastagliata.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X75964 mRNA. Translation: CAA53578.1.
UniGeneVvi.120.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2IODX-ray2.06A/B/C/D1-337[»]
2NNLX-ray2.10D/F1-337[»]
3BXXX-ray2.90A/B/C/D/E/F1-337[»]
3C1TX-ray2.25A/B/C/D1-337[»]
ProteinModelPortalP51110.
SMRP51110. Positions 5-330.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP51110.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00009.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01370. Epimerase. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP51110.

Entry information

Entry nameDFRA_VITVI
AccessionPrimary (citable) accession number: P51110
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways