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P51110

- DFRA_VITVI

UniProt

P51110 - DFRA_VITVI

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Protein

Dihydroflavonol-4-reductase

Gene

DFR

Organism
Vitis vinifera (Grape)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH.

Pathwayi

GO - Molecular functioni

  1. coenzyme binding Source: EnsemblPlants/Gramene
  2. dihydrokaempferol 4-reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. anthocyanin-containing compound biosynthetic process Source: UniProtKB-UniPathway
  2. cellular metabolic process Source: EnsemblPlants/Gramene
  3. response to sucrose Source: EnsemblPlants/Gramene
  4. response to UV-B Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Flavonoid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00009.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroflavonol-4-reductase (EC:1.1.1.219)
Short name:
DFR
Alternative name(s):
Dihydrokaempferol 4-reductase
Gene namesi
Name:DFR
OrganismiVitis vinifera (Grape)
Taxonomic identifieri29760 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsVitalesVitaceaeVitis

Subcellular locationi

GO - Cellular componenti

  1. extrinsic component of endoplasmic reticulum membrane Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Dihydroflavonol-4-reductasePRO_0000215572Add
BLAST

Proteomic databases

PRIDEiP51110.

Expressioni

Inductioni

By light.

Gene expression databases

ExpressionAtlasiP51110. differential.

Structurei

Secondary structure

1
337
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 126Combined sources
Helixi16 – 2712Combined sources
Beta strandi31 – 377Combined sources
Helixi42 – 498Combined sources
Helixi54 – 574Combined sources
Beta strandi58 – 625Combined sources
Turni68 – 714Combined sources
Helixi72 – 754Combined sources
Beta strandi79 – 835Combined sources
Helixi95 – 984Combined sources
Helixi100 – 11617Combined sources
Beta strandi121 – 1266Combined sources
Helixi129 – 1313Combined sources
Beta strandi135 – 1373Combined sources
Beta strandi140 – 1423Combined sources
Helixi150 – 1567Combined sources
Helixi161 – 18020Combined sources
Beta strandi185 – 1906Combined sources
Beta strandi192 – 1954Combined sources
Beta strandi198 – 2014Combined sources
Helixi204 – 2096Combined sources
Helixi211 – 2144Combined sources
Helixi217 – 2193Combined sources
Turni221 – 2244Combined sources
Beta strandi225 – 2306Combined sources
Helixi231 – 24313Combined sources
Beta strandi249 – 2535Combined sources
Beta strandi256 – 2594Combined sources
Helixi260 – 27011Combined sources
Helixi295 – 2995Combined sources
Helixi308 – 32114Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IODX-ray2.06A/B/C/D1-337[»]
2NNLX-ray2.10D/F1-337[»]
3BXXX-ray2.90A/B/C/D/E/F1-337[»]
3C1TX-ray2.25A/B/C/D1-337[»]
ProteinModelPortaliP51110.
SMRiP51110. Positions 5-330.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51110.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001509. Epimerase_deHydtase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51110-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSQSETVCV TGASGFIGSW LVMRLLERRL TVRATVRDPT NVKKVKHLLD
60 70 80 90 100
LPKAETHLTL WKADLADEGS FDEAIKGCTG VFHVATPMDF ESKDPENEVI
110 120 130 140 150
KPTIEGMLGI MKSCAAAKTV RRLVFTSSAG TVNIQEHQLP VYDESCWSDM
160 170 180 190 200
EFCRAKKMTA WMYFVSKTLA EQAAWKYAKE NNIDFITIIP TLVVGPFIMS
210 220 230 240 250
SMPPSLITAL SPITGNEAHY SIIRQGQFVH LDDLCNAHIY LFENPKAEGR
260 270 280 290 300
YICSSHDCII LDLAKMLREK YPEYNIPTEF KGVDENLKSV CFSSKKLTDL
310 320 330
GFEFKYSLED MFTGAVDTCR AKGLLRPSHE KPVDGKT
Length:337
Mass (Da):37,757
Last modified:October 1, 1996 - v1
Checksum:i73EDB67A03DF94E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75964 mRNA. Translation: CAA53578.1.
UniGeneiVvi.120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75964 mRNA. Translation: CAA53578.1 .
UniGenei Vvi.120.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2IOD X-ray 2.06 A/B/C/D 1-337 [» ]
2NNL X-ray 2.10 D/F 1-337 [» ]
3BXX X-ray 2.90 A/B/C/D/E/F 1-337 [» ]
3C1T X-ray 2.25 A/B/C/D 1-337 [» ]
ProteinModelPortali P51110.
SMRi P51110. Positions 5-330.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P51110.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00009 .

Miscellaneous databases

EvolutionaryTracei P51110.

Gene expression databases

ExpressionAtlasi P51110. differential.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR001509. Epimerase_deHydtase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01370. Epimerase. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and molecular analysis of structural genes involved in flavonoid and stilbene biosynthesis in grape (Vitis vinifera L.)."
    Sparvoli F., Martin C., Scienza A., Gavazzi G., Tonelli C.
    Plant Mol. Biol. 24:743-755(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Lambrusco Foglia Frastagliata.

Entry informationi

Entry nameiDFRA_VITVI
AccessioniPrimary (citable) accession number: P51110
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3