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P51110

- DFRA_VITVI

UniProt

P51110 - DFRA_VITVI

Protein

Dihydroflavonol-4-reductase

Gene

DFR

Organism
Vitis vinifera (Grape)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH.

    Pathwayi

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. dihydrokaempferol 4-reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. anthocyanin-containing compound biosynthetic process Source: UniProtKB-UniPathway
    2. cellular metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydroflavonol-4-reductase (EC:1.1.1.219)
    Short name:
    DFR
    Alternative name(s):
    Dihydrokaempferol 4-reductase
    Gene namesi
    Name:DFR
    OrganismiVitis vinifera (Grape)
    Taxonomic identifieri29760 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsVitalesVitaceaeVitis

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Dihydroflavonol-4-reductasePRO_0000215572Add
    BLAST

    Proteomic databases

    PRIDEiP51110.

    Expressioni

    Inductioni

    By light.

    Structurei

    Secondary structure

    1
    337
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi7 – 126
    Helixi16 – 2712
    Beta strandi31 – 377
    Helixi42 – 498
    Helixi54 – 574
    Beta strandi58 – 625
    Turni68 – 714
    Helixi72 – 754
    Beta strandi79 – 835
    Helixi95 – 984
    Helixi100 – 11617
    Beta strandi121 – 1266
    Helixi129 – 1313
    Beta strandi135 – 1373
    Beta strandi140 – 1423
    Helixi150 – 1567
    Helixi161 – 18020
    Beta strandi185 – 1906
    Beta strandi192 – 1954
    Beta strandi198 – 2014
    Helixi204 – 2096
    Helixi211 – 2144
    Helixi217 – 2193
    Turni221 – 2244
    Beta strandi225 – 2306
    Helixi231 – 24313
    Beta strandi249 – 2535
    Beta strandi256 – 2594
    Helixi260 – 27011
    Helixi295 – 2995
    Helixi308 – 32114

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2IODX-ray2.06A/B/C/D1-337[»]
    2NNLX-ray2.10D/F1-337[»]
    3BXXX-ray2.90A/B/C/D/E/F1-337[»]
    3C1TX-ray2.25A/B/C/D1-337[»]
    ProteinModelPortaliP51110.
    SMRiP51110. Positions 5-330.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP51110.

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR001509. Epimerase_deHydtase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01370. Epimerase. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51110-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSQSETVCV TGASGFIGSW LVMRLLERRL TVRATVRDPT NVKKVKHLLD    50
    LPKAETHLTL WKADLADEGS FDEAIKGCTG VFHVATPMDF ESKDPENEVI 100
    KPTIEGMLGI MKSCAAAKTV RRLVFTSSAG TVNIQEHQLP VYDESCWSDM 150
    EFCRAKKMTA WMYFVSKTLA EQAAWKYAKE NNIDFITIIP TLVVGPFIMS 200
    SMPPSLITAL SPITGNEAHY SIIRQGQFVH LDDLCNAHIY LFENPKAEGR 250
    YICSSHDCII LDLAKMLREK YPEYNIPTEF KGVDENLKSV CFSSKKLTDL 300
    GFEFKYSLED MFTGAVDTCR AKGLLRPSHE KPVDGKT 337
    Length:337
    Mass (Da):37,757
    Last modified:October 1, 1996 - v1
    Checksum:i73EDB67A03DF94E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75964 mRNA. Translation: CAA53578.1.
    UniGeneiVvi.120.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75964 mRNA. Translation: CAA53578.1 .
    UniGenei Vvi.120.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2IOD X-ray 2.06 A/B/C/D 1-337 [» ]
    2NNL X-ray 2.10 D/F 1-337 [» ]
    3BXX X-ray 2.90 A/B/C/D/E/F 1-337 [» ]
    3C1T X-ray 2.25 A/B/C/D 1-337 [» ]
    ProteinModelPortali P51110.
    SMRi P51110. Positions 5-330.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P51110.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00009 .

    Miscellaneous databases

    EvolutionaryTracei P51110.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR001509. Epimerase_deHydtase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01370. Epimerase. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and molecular analysis of structural genes involved in flavonoid and stilbene biosynthesis in grape (Vitis vinifera L.)."
      Sparvoli F., Martin C., Scienza A., Gavazzi G., Tonelli C.
      Plant Mol. Biol. 24:743-755(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Lambrusco Foglia Frastagliata.

    Entry informationi

    Entry nameiDFRA_VITVI
    AccessioniPrimary (citable) accession number: P51110
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3