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Protein

Dihydroflavonol 4-reductase

Gene

DFR1

Organism
Medicago sativa (Alfalfa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Bifunctional enzyme involved in flavonoid metabolism.By similarity

Catalytic activityi

A (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH.By similarity
(2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH.By similarity

Pathwayi: anthocyanin biosynthesis

This protein is involved in the pathway anthocyanin biosynthesis, which is part of Pigment biosynthesis.
View all proteins of this organism that are known to be involved in the pathway anthocyanin biosynthesis and in Pigment biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Flavonoid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00009.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroflavonol 4-reductase (EC:1.1.1.219By similarity)
Short name:
DFR
Alternative name(s):
Dihydrokaempferol 4-reductase
Flavanone 4-reductase (EC:1.1.1.234By similarity)
Short name:
FNR
Gene namesi
Name:DFR1
OrganismiMedicago sativa (Alfalfa)
Taxonomic identifieri3879 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000215570‹1 – ›217Dihydroflavonol 4-reductaseAdd BLAST›217

Proteomic databases

PRIDEiP51109.

Structurei

3D structure databases

ProteinModelPortaliP51109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Fragment.

P51109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GSWLVMRLME PGYMVRATVR DPENLKKVSP LLELPGAKSK LSIWKADLGE
60 70 80 90 100
EGSFDEAIKG CTGVFHVATP MDFESKDPEN EMIKPTIKGV LDIMKACLKA
110 120 130 140 150
KTVRRLIYTS SAGTLNVTED QKPLWDESCW SDVEFCRRVK MTGWMYFVSK
160 170 180 190 200
TLAEQEAWKF AKEHKMDVIT IIPPLVVGPF LIPTMPPSLI TALSPITGNE
210
AHYSIIKQGQ YVHLDDL
Length:217
Mass (Da):24,389
Last modified:October 1, 1996 - v1
Checksum:iE8A43AA76CBE3EB2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei2171

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80222 mRNA. Translation: CAA56508.1.
PIRiS61416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80222 mRNA. Translation: CAA56508.1.
PIRiS61416.

3D structure databases

ProteinModelPortaliP51109.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP51109.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00009.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDFRA_MEDSA
AccessioniPrimary (citable) accession number: P51109
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.