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P51106 (DFRA_HORVU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydroflavonol-4-reductase

Short name=DFR
EC=1.1.1.219
Alternative name(s):
Dihydrokaempferol 4-reductase
Gene names
Name:ANT18
OrganismHordeum vulgare (Barley)
Taxonomic identifier4513 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH.

Pathway

Pigment biosynthesis; anthocyanin biosynthesis.

Sequence similarities

Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Dihydroflavonol-4-reductase
PRO_0000215567

Sequences

Sequence LengthMass (Da)Tools
P51106 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 528524A832815AC9

FASTA35438,435
        10         20         30         40         50         60 
MDGNKGPVVV TGASGFVGSW LVMKLLQAGY TVRATVRDPA NVEKTKPLLE LPGAKERLSI 

        70         80         90        100        110        120 
WKADLSEDGS FNEAIAGCTG VFHVATPMDF DSQDPENEVI KPTVEGMLSI MRACKEAGTV 

       130        140        150        160        170        180 
KRIVFTSSAG SVNIEERPRP AYDQDNWSDI DYCRRVKMTG WMYFVSKALA EKAAMEYASE 

       190        200        210        220        230        240 
NGLDFISIIP TLVVGPFLSA GMPPSLVTAL ALITGNEAHY SILKQVQLVH LDDLCDAMTF 

       250        260        270        280        290        300 
LFEHPEANGR YICSSHDATI HGLARMLQDR FPEYDIPQKF AGVDDNLQPI HFSSKKLLDH 

       310        320        330        340        350 
GFSFRYTTED MFDAAIHTCR DKGLIPLGDV PAPAAGGKLG ALAAGEGQAI GAET 

« Hide

References

[1]"Structure of the Hordeum vulgare gene encoding dihydroflavonol-4-reductase and molecular analysis of ant18 mutants blocked in flavonoid synthesis."
Kristiansen K.N., Rohde W.
Mol. Gen. Genet. 230:49-59(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Gula.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S69616 Genomic DNA. Translation: AAB20555.1.
PIRS18595.

3D structure databases

ProteinModelPortalP51106.
SMRP51106. Positions 8-326.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneP51106.

Enzyme and pathway databases

UniPathwayUPA00009.

Gene expression databases

GenevestigatorP51106.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01370. Epimerase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDFRA_HORVU
AccessionPrimary (citable) accession number: P51106
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways