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P51105 (DFRA_GERHY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydroflavonol-4-reductase

Short name=DFR
EC=1.1.1.219
Alternative name(s):
Dihydrokaempferol 4-reductase
Gene names
Name:DFR
OrganismGerbera hybrida (Daisy)
Taxonomic identifier18101 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeMutisioideaeMutisieaeGerbera

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH.

Pathway

Pigment biosynthesis; anthocyanin biosynthesis.

Sequence similarities

Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Dihydroflavonol-4-reductase
PRO_0000215566

Sequences

Sequence LengthMass (Da)Tools
P51105 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 8B12719BD0D73165

FASTA36641,102
        10         20         30         40         50         60 
MEEDSPATVC VTGAAGFIGS WLVMRLLERG YVVHATVRDP GDLKKVKHLL ELPKAQTNLK 

        70         80         90        100        110        120 
LWKADLTQEG SFDEAIQGCH GVFHLATPMD FESKDPENEI IKPTIEGVLS IIRSCVKAKT 

       130        140        150        160        170        180 
VKKLVFTSSA GTVNGQEKQL HVYDESHWSD LDFIYSKKMT AWMYFVSKTL AEKAAWDATK 

       190        200        210        220        230        240 
GNNISFISII PTLVVGPFIT STFPPSLVTA LSLITGNEAH YSIIKQGQYV HLDDLCECHI 

       250        260        270        280        290        300 
YLYENPKAKG RYICSSHDAT IHQLAKIIKD KWPEYYIPTK FPGIDEELPI VSFSSKKLID 

       310        320        330        340        350        360 
TGFEFKYNLE DMFKGAIDTC REKGLLPYST IKNHINGNHV NGVHHYIKNN DDDHEKGLLC 


CSKEGQ 

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References

[1]"Cloning of cDNA coding for dihydroflavonol-4-reductase (DFR) and characterization of dfr expression in the corollas of Gerbera hybrida var. Regina (Compositae)."
Helariutta Y., Elomaa P., Kotilainen M., Seppanen P., Teeri T.H.
Plant Mol. Biol. 22:183-193(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Regina.
Tissue: Corolla.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z17221 mRNA. Translation: CAA78930.1.
PIRS35189.

3D structure databases

ProteinModelPortalP51105.
SMRP51105. Positions 8-329.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA1.1.1.219. 2420.
UniPathwayUPA00009.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01370. Epimerase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDFRA_GERHY
AccessionPrimary (citable) accession number: P51105
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways