Reviewed,
UniProtKB/Swiss-Prot P51092 (LDOX_PETHY)
Last modified
January 19, 2010.
Version 52.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Leucoanthocyanidin dioxygenase Short name=LDOX Short name=Leucocyanidin oxygenase EC=1.14.11.19 Alternative name(s): Leucoanthocyanidin hydroxylase | ||
| Gene names |
| ||
| Organism | Petunia hybrida (Petunia) | ||
| Taxonomic identifier | 4102 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Petunioideae › Petunia |
Protein attributes
| Sequence length | 430 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Oxidation of leucoanthocyanidins into anthocyanidins. |
| Catalytic activity | Leucocyanidin + 2-oxoglutarate + O2 = cis- and trans-dihydroquercetins + succinate + CO2 + H2O. |
| Cofactor | Binds 1 iron ion per subunit By similarity. Binds 1 ascorbate molecule per subunit By similarity. |
| Pathway | |
| Tissue specificity | Predominantly expressed in corollas and at lower levels in anthers. |
| Induction | By gibberellic acid (GA). |
| Sequence similarities | Belongs to the iron/ascorbate-dependent oxidoreductase family. Contains 1 Fe2OG dioxygenase domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Flavonoid biosynthesis |
| Ligand | Iron Metal-binding Vitamin C |
| Molecular function | Dioxygenase Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | flavonoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | L-ascorbic acid binding Inferred from electronic annotation. Source: UniProtKB-KW iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW leucocyanidin oxygenase activityInferred from electronic annotation. Source: EC oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 430 | 430 | Leucoanthocyanidin dioxygenase | PRO_0000067303 | |||||
Regions | |||||||||
| Domain | 212 – 311 | 100 | Fe2OG dioxygenase | ||||||
Sites | |||||||||
| Metal binding | 236 | 1 | Iron By similarity | ||||||
| Metal binding | 238 | 1 | Iron By similarity | ||||||
| Metal binding | 292 | 1 | Iron By similarity | ||||||
Sequences
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References
| [1] | "The petunia homologue of the Antirrhinum majus candi and Zea mays A2 flavonoid genes; homology to flavanone 3-hydroxylase and ethylene-forming enzyme." Weiss D., van der Luit A.H., Kroon J.T.M., Mol J.N.M., Kooter J.M. Plant Mol. Biol. 22:893-897(1993) [PubMed: 8358035] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Violet 26. Tissue: Corolla. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X70786 mRNA. No translation available. |
| PIR | S36233. |
3D structure databases | |
| SMR | P51092. Positions 11-350. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 1.14.11.19. 2263. |
Family and domain databases | |
| InterPro | IPR005123. Oxoglutarate/Fe-dep_oxygenase. [Graphical view] |
| Pfam | PF03171. 2OG-FeII_Oxy. 1 hit. [Graphical view] |
| PROSITE | PS51471. FE2OG_OXY. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LDOX_PETHY | ||||||||
| Accession | Primary (citable) accession number: P51092 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


