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Reviewed, UniProtKB/Swiss-Prot P51091 (LDOX_MALDO)

Last modified February 9, 2010. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Leucoanthocyanidin dioxygenase
      Short name=LDOX
      Short name=Leucocyanidin oxygenase
    EC=1.14.11.19
Alternative name(s):
    Leucoanthocyanidin hydroxylase
    Anthocyanidin synthase
Gene names
Name: ANS
OrganismMalus domestica (Apple) (Pyrus malus)
Taxonomic identifier3750 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsrosidsfabidsRosalesRosaceaeMaloideaeMalus

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Oxidation of leucoanthocyanidins into anthocyanidins.

Catalytic activity

Leucocyanidin + 2-oxoglutarate + O2 = cis- and trans-dihydroquercetins + succinate + CO2 + H2O.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 ascorbate molecule per subunit By similarity.

Pathway

Pigment biosynthesis; anthocyanin biosynthesis.

Sequence similarities

Belongs to the iron/ascorbate-dependent oxidoreductase family.

Contains 1 Fe2OG dioxygenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Leucoanthocyanidin dioxygenase
PRO_0000067301

Regions

Domain212 – 311100Fe2OG dioxygenase

Sites

Metal binding2361Iron By similarity
Metal binding2381Iron By similarity
Metal binding2921Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
P51091-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: FA5D97C25267B3E6

FASTA35740,332
        10         20         30         40         50         60 
MVSSDSVNSR VETLAGSGIS TIPKEYIRPK DELVNIGDIF EQEKNNEGPQ VPTIDLKEIE 

        70         80         90        100        110        120 
SDNEKVRAKC REKLKKAAVD WGVMHLVNHG ISDELMDKVR KAGKAFFDLP IEQKEKYAND 

       130        140        150        160        170        180 
QASGKIQGYG SKLANNASGQ LEWEDYFFHC VYPEDKRDLS IWPQTPADYI EATAEYAKQL 

       190        200        210        220        230        240 
RELATKVLKV LSLGLGLDEG RLEKEVGGLE ELLLQMKINY YPKCPQPELA LGVEAHTDVS 

       250        260        270        280        290        300 
ALTFILHNMV PGLQLFYEGK WVTAKCVPNS IVMHIGDTLE ILSNGKYKSI LHRGMVNKEK 

       310        320        330        340        350 
VRISWAVFCE PPKEKIILKP LPETVSEDEP AMFPPRTFAE HIQHKLFRKS QEALLPK 

« Hide

References

[1]"A Malus cDNA with homology to the Antirrhinum Candica and Zea A2 genes."
Davies K.M.
Plant Physiol. 103:1015-1015(1993) [PubMed: 8022923] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Leaf.
[2]"Molecular cloning and expression of anthocyanin biosynthesis genes from 'Fuji apple'."
Lee J.-R., Hong S.-T., Yoo Y.G., Kim S.-R.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Fuji.
Tissue: Peelings.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X71360 mRNA. Translation: CAA50498.1.
AF117269 mRNA. Translation: AAD26205.1.
PIRS33144.

3D structure databases

SMRP51091. Positions 10-354.
ModBaseSearch...

Enzyme and pathway databases

BRENDA1.14.11.19. 66979.

Family and domain databases

InterProIPR005123. Oxoglutarate/Fe-dep_oxygenase.
[Graphical view]
PfamPF03171. 2OG-FeII_Oxy. 1 hit.
[Graphical view]
PROSITEPS51471. FE2OG_OXY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLDOX_MALDO
AccessionPrimary (citable) accession number: P51091
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 9, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents