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Protein

Chalcone synthase

Gene

CHS

Organism
Vitis vinifera (Grape)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase
Gene namesi
Name:CHS
OrganismiVitis vinifera (Grape)
Taxonomic identifieri29760 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsVitalesVitaceaeVitis

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Chalcone synthasePRO_0000216075Add
BLAST

Proteomic databases

PRIDEiP51090.

Expressioni

Inductioni

By light.

Gene expression databases

ExpressionAtlasiP51090. differential.

Structurei

3D structure databases

ProteinModelPortaliP51090.
SMRiP51090. Positions 3-388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

eggNOGiCOG3424.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51090-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSVAEIRKA QRAEGPATVL AIGTATPANC VYQADYPDYY FRITNSEHMT
60 70 80 90 100
ELKEKFKRMC EKSMINKRYM HLTEEILKEN PNVCAYMAPS LDARQDMVVV
110 120 130 140 150
EVPKLGKEAA AKAIKEWGQP KSKITHLVFC TTSGVDMPGA DYQLTKLLGL
160 170 180 190 200
KPSVKRLMMY QQGCFAGGTV LRLAKDLAEN NAGSRVLVVC SEITAVTFRG
210 220 230 240 250
PSDTHLDSLV GQALFGDGAA AVIIGADPDT KIELPLFELV SAAQTILPDS
260 270 280 290 300
EGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLVEAFTPI GISDWNSLFW
310 320 330 340 350
IAHPGGPAIL DQVELKLGLK EEKLRATRHV LSEYGNMSSA CVLFILDEMR
360 370 380 390
KKSIEEGKGS TGEGLEWGVL FGFGPGLTVE TVVLHSVSAP AAH
Length:393
Mass (Da):42,701
Last modified:October 1, 1996 - v1
Checksum:iC44992BDFF4EE146
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75969 mRNA. Translation: CAA53583.1.
UniGeneiVvi.117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75969 mRNA. Translation: CAA53583.1.
UniGeneiVvi.117.

3D structure databases

ProteinModelPortaliP51090.
SMRiP51090. Positions 3-388.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP51090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG3424.

Enzyme and pathway databases

UniPathwayiUPA00154.

Gene expression databases

ExpressionAtlasiP51090. differential.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and molecular analysis of structural genes involved in flavonoid and stilbene biosynthesis in grape (Vitis vinifera L.)."
    Sparvoli F., Martin C., Scienza A., Gavazzi G., Tonelli C.
    Plant Mol. Biol. 24:743-755(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Lambrusco Foglia Frastagliata.

Entry informationi

Entry nameiCHSY_VITVI
AccessioniPrimary (citable) accession number: P51090
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.