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P51080 (CHS7_MEDSA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase
Gene names
Name:CHSII
OrganismMedicago sativa (Alfalfa)
Taxonomic identifier3879 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

Protein attributes

Sequence length265 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Induction

By infection.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 265›265Chalcone synthase
PRO_0000216012

Sites

Active site401 By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P51080 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 8A4659A0DF564A1F

FASTA26528,621
        10         20         30         40         50         60 
ITHLIVCTTS VDMPGADYQL TKLLGLRPYV KRYMMYQQGC FAGGTVLRLA KDLAENNKGA 

        70         80         90        100        110        120 
RVLVVCSEVT AVTFRGPSDT HLDSLVGQAL FGDGAAALIV GSDPVPEIEK PIFEMVWTAQ 

       130        140        150        160        170        180 
TIAPDSEGAI DGHLREAGLT FHLLKDVPGI VSKNINKALV EAFEPLGISD YNSIFWIAHP 

       190        200        210        220        230        240 
GGPAILDQVE QKLALKPEKM KATREVLSEY GNMSSACVLF ILDEMRKKSA QDGLKTTGEG 

       250        260 
LEWGVLFGFG PGLTIETVVL RSVTI 

« Hide

References

[1]"Pathological and molecular characterizations of alfalfa interactions with compatible and incompatible bacteria, Xanthomonas campestris pv. alfalfae and Pseudomonas syringae pv. pisi."
Esnault R., Buffard D., Breda C., Sallaud C., El-Turk J., Kondorosi A.
Mol. Plant Microbe Interact. 6:655-664(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Nagyszenasi.
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X68107 mRNA. Translation: CAA48227.1.
PIRS26415.

3D structure databases

ProteinModelPortalP51080.
SMRP51080. Positions 1-265.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS7_MEDSA
AccessionPrimary (citable) accession number: P51080
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways