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P51079

- CHS6_MEDSA

UniProt

P51079 - CHS6_MEDSA

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Protein

Chalcone synthase 6-4

Gene

CHS6-4

Organism
Medicago sativa (Alfalfa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei60 – 601PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 6-4 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 6-4
Gene namesi
Name:CHS6-4
OrganismiMedicago sativa (Alfalfa)
Taxonomic identifieri3879 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 285›285Chalcone synthase 6-4PRO_0000216011Add
BLAST

Expressioni

Developmental stagei

Highest expression in young root tips.

Structurei

3D structure databases

ProteinModelPortaliP51079.
SMRiP51079. Positions 1-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 1 hit.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P51079-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LGKEAAVKAI KEWGQPKSKI THLIFCTTSG VDMPGADYQL TKLLGLRPYV
60 70 80 90 100
KRYMMYQQGC FAGGTVLRLA KDLAENNKGA RVLVVCSEVT AVTFRGPSDT
110 120 130 140 150
HLDSLVGQAL FGDGAAALIV GSDPIPEIEK PIFEMVWTAQ TIAPDSEGAI
160 170 180 190 200
DGHLREAGLT FHLLKDVPGI VSKNIDKALV EAFQPLNISD YNSIFWIAHP
210 220 230 240 250
GGPAILDQVE QKLGLKPEKM KATREVLSEY GNMSSACVLF ILDEMRKKSA
260 270 280
QQGLKTTGEG LDWGVLFGFG PGLTIETVVL HSVAL
Length:285
Mass (Da):30,784
Last modified:October 1, 1996 - v1
Checksum:i76C2C0D02AA81FF3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01020 mRNA. Translation: AAB41558.1.
PIRiS44369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01020 mRNA. Translation: AAB41558.1 .
PIRi S44369.

3D structure databases

ProteinModelPortali P51079.
SMRi P51079. Positions 1-285.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 1 hit.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of chalcone synthase and chalcone isomerase cDNAs from alfalfa (Medicago sativa L.): highest transcript levels occur in young roots and root tips."
    McKhann H.I., Hirsch A.M.
    Plant Mol. Biol. 24:767-777(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Iroquois.
    Tissue: Root nodule.

Entry informationi

Entry nameiCHS6_MEDSA
AccessioniPrimary (citable) accession number: P51079
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3