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P51079 (CHS6_MEDSA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase 6-4

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase 6-4
Gene names
Name:CHS6-4
OrganismMedicago sativa (Alfalfa)
Taxonomic identifier3879 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

Protein attributes

Sequence length285 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Developmental stage

Highest expression in young root tips.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 285›285Chalcone synthase 6-4
PRO_0000216011

Sites

Active site601 By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P51079 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 76C2C0D02AA81FF3

FASTA28530,784
        10         20         30         40         50         60 
LGKEAAVKAI KEWGQPKSKI THLIFCTTSG VDMPGADYQL TKLLGLRPYV KRYMMYQQGC 

        70         80         90        100        110        120 
FAGGTVLRLA KDLAENNKGA RVLVVCSEVT AVTFRGPSDT HLDSLVGQAL FGDGAAALIV 

       130        140        150        160        170        180 
GSDPIPEIEK PIFEMVWTAQ TIAPDSEGAI DGHLREAGLT FHLLKDVPGI VSKNIDKALV 

       190        200        210        220        230        240 
EAFQPLNISD YNSIFWIAHP GGPAILDQVE QKLGLKPEKM KATREVLSEY GNMSSACVLF 

       250        260        270        280 
ILDEMRKKSA QQGLKTTGEG LDWGVLFGFG PGLTIETVVL HSVAL 

« Hide

References

[1]"Isolation of chalcone synthase and chalcone isomerase cDNAs from alfalfa (Medicago sativa L.): highest transcript levels occur in young roots and root tips."
McKhann H.I., Hirsch A.M.
Plant Mol. Biol. 24:767-777(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Iroquois.
Tissue: Root nodule.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U01020 mRNA. Translation: AAB41558.1.
PIRS44369.

3D structure databases

ProteinModelPortalP51079.
SMRP51079. Positions 1-285.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
SUPFAMSSF53901. SSF53901. 1 hit.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS6_MEDSA
AccessionPrimary (citable) accession number: P51079
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways