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Protein

Chalcone synthase 6-4

Gene

CHS6-4

Organism
Medicago sativa (Alfalfa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi: flavonoid biosynthesis

This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei60PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFlavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 6-4 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 6-4
Gene namesi
Name:CHS6-4
OrganismiMedicago sativa (Alfalfa)
Taxonomic identifieri3879 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000216011‹1 – 285Chalcone synthase 6-4Add BLAST›285

Expressioni

Developmental stagei

Highest expression in young root tips.

Structurei

3D structure databases

ProteinModelPortaliP51079.
SMRiP51079.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiView protein in InterPro
IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR016039. Thiolase-like.
PfamiView protein in Pfam
PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
SUPFAMiSSF53901. SSF53901. 1 hit.
PROSITEiView protein in PROSITE
PS00441. CHALCONE_SYNTH. 1 hit.

Sequencei

Sequence statusi: Fragment.

P51079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LGKEAAVKAI KEWGQPKSKI THLIFCTTSG VDMPGADYQL TKLLGLRPYV
60 70 80 90 100
KRYMMYQQGC FAGGTVLRLA KDLAENNKGA RVLVVCSEVT AVTFRGPSDT
110 120 130 140 150
HLDSLVGQAL FGDGAAALIV GSDPIPEIEK PIFEMVWTAQ TIAPDSEGAI
160 170 180 190 200
DGHLREAGLT FHLLKDVPGI VSKNIDKALV EAFQPLNISD YNSIFWIAHP
210 220 230 240 250
GGPAILDQVE QKLGLKPEKM KATREVLSEY GNMSSACVLF ILDEMRKKSA
260 270 280
QQGLKTTGEG LDWGVLFGFG PGLTIETVVL HSVAL
Length:285
Mass (Da):30,784
Last modified:October 1, 1996 - v1
Checksum:i76C2C0D02AA81FF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01020 mRNA. Translation: AAB41558.1.
PIRiS44369.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCHS6_MEDSA
AccessioniPrimary (citable) accession number: P51079
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 15, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families