P51076 (CHSY_FRAAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Chalcone synthase RJ5 EC=2.3.1.74 Alternative name(s): Naringenin-chalcone synthase
Organism	Fragaria ananassa (Strawberry)
Taxonomic identifier	3747 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Rosales › Rosaceae › Rosoideae › Potentilleae › Fragariinae › Fragaria

Protein attributes

Sequence length	99 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
Catalytic activity	3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.
Pathway	Secondary metabolite biosynthesis; flavonoid biosynthesis.
Tissue specificity	Predominantly in developing fruit.
Developmental stage	Expression of the protein is enhanced in a ripening fruit.
Sequence similarities	Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
Biological process	Flavonoid biosynthesis
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological_process	flavonoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	naringenin-chalcone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 99	›99	Chalcone synthase RJ5		PRO_0000215976
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P51076 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 38F83B45F6B1179B	FASTA	99	10,715
	10 20 30 40 50 60 NITDWNSLFW IAHPGGPAIL DQVEAKLALK PEKLEATRHI LSEYGNMSSA CVLFILDEVR 70 80 90 RKSAANGHKT TGEGLEWGVL FGFGPGLTVE TVVLHSVSA

References

[1]

"Identification of mRNAs with enhanced expression in ripening strawberry fruit using polymerase chain reaction differential display." Wilkinson J.Q., Lanahan M.B., Conner T.W., Klee H.J. Plant Mol. Biol. 27:1097-1108(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Pajaro. Tissue: Fruit.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U19942 mRNA. Translation: AAA79923.1.
PIR	S56675.
3D structure databases
ProteinModelPortal	P51076.
SMR	P51076. Positions 2-98.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00154.
Family and domain databases
Gene3D	3.40.47.10. 1 hit.
InterPro	IPR012328. Chalcone/stilbene_synth_C. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Pfam	PF02797. Chal_sti_synt_C. 1 hit. [Graphical view]
SUPFAM	SSF53901. Thiolase-like. 1 hit.
PROSITE	PS00441. CHALCONE_SYNTH. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHSY_FRAAN

Accession

Primary (citable) accession number: P51076

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program