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Protein

Chalcone synthase

Gene

CHS

Organism
Betula pendula (European white birch) (Betula verrucosa)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi: flavonoid biosynthesis

This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei164PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFlavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase
Gene namesi
Name:CHS
OrganismiBetula pendula (European white birch) (Betula verrucosa)
Taxonomic identifieri3505 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeBetula

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002159551 – 395Chalcone synthaseAdd BLAST395

Proteomic databases

PRIDEiP51075

Expressioni

Inductioni

By ozone.

Structurei

3D structure databases

ProteinModelPortaliP51075
SMRiP51075
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR012328 Chalcone/stilbene_synth_C
IPR018088 Chalcone/stilbene_synthase_AS
IPR001099 Chalcone/stilbene_synthase_N
IPR011141 Polyketide_synthase_type-III
IPR016039 Thiolase-like
PANTHERiPTHR11877 PTHR11877, 1 hit
PfamiView protein in Pfam
PF02797 Chal_sti_synt_C, 1 hit
PF00195 Chal_sti_synt_N, 1 hit
PIRSFiPIRSF000451 PKS_III, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
PROSITEiView protein in PROSITE
PS00441 CHALCONE_SYNTH, 1 hit

Sequencei

Sequence statusi: Complete.

P51075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVEEIRKA QRAHGPATVL AIGTATPSNC ITQADYPDYY FRITKSDHMT
60 70 80 90 100
ELKEKFKRMC DKSMIKKRYM YLNEEILNEN PNMCAYMAPS LDARQTIVVV
110 120 130 140 150
EVPKLGKEAA TKAIKEWGQP KSKITHLVFC TTSGVDMPGA DYQLTKLLGL
160 170 180 190 200
RPSVKRLMMY QQGCFAGGTV LRLAKDLAEN NKGARVLVVC SEITAVTFRG
210 220 230 240 250
PTDTHLDSLV GQALFGDGAA AVIVGADPDT SVERPLFELI SAAQTILPDS
260 270 280 290 300
DGAIDGHLRE VGLTFHLLKD VPGIISKNIE KSLAEAFAPL GISDWNSLFW
310 320 330 340 350
IAHPGGPAIL DQVESKLGLK EEKLRATRHV LSEYGNMSSA CVLFILDEMR
360 370 380 390
RNSLEGGKVT TGEGLEWGVL FGFGPGLTVE TVVLHSVPVP VEASH
Length:395
Mass (Da):43,016
Last modified:July 15, 1999 - v2
Checksum:i18D25119A8891A17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11022 mRNA Translation: CAA71904.1
X77513 Genomic DNA Translation: CAA54649.1
PIRiS41957

Similar proteinsi

Entry informationi

Entry nameiCHSY_BETPN
AccessioniPrimary (citable) accession number: P51075
Secondary accession number(s): P93069
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1999
Last modified: May 23, 2018
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

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