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P51066

- ACEA_SALTY

UniProt

P51066 - ACEA_SALTY

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Protein

Isocitrate lyase

Gene

aceA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase-positive serine pathway (By similarity).By similarity

Catalytic activityi

Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

Cofactori

Divalent cations.

Enzyme regulationi

Is activated by phosphorylation (on histidine) and is inhibited by PEP, 3-phosphoglycerate and succinate.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei195 – 1951PROSITE-ProRule annotation

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4214-MONOMER.
UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Gene namesi
Name:aceA
Ordered Locus Names:STM4184
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Isocitrate lyasePRO_0000068776Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP51066.
PRIDEiP51066.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi99287.STM4184.

Structurei

3D structure databases

ProteinModelPortaliP51066.
SMRiP51066. Positions 2-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2224.
HOGENOMiHOG000238475.
KOiK01637.
OMAiDQIQWAN.
OrthoDBiEOG689HMX.
PhylomeDBiP51066.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 2 hits.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51066-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTRTQQIEE LQKEWTQPRW EGITRPYSAE EVVKLRGSVN PECTLAQLGA
60 70 80 90 100
AKMWRLLHGE AKKGYINSLG ALTGGQALQQ AKAGIEAIYL SGWQVAADAN
110 120 130 140 150
LASSMYPDQS LYPANSVPAV VDRINNTFRR ADQIQWASGI EPNDPRYVDY
160 170 180 190 200
FLPIVADAEA GFGGVLNAFE LMKSMIEAGA AAVHFEDQLA SVKKCGHMGG
210 220 230 240 250
KVLVPTQEAI QKLVAARLAA DVMGVPTLVI ARTDADAADL ITSDCDPYDS
260 270 280 290 300
GFITGERTSE GFYRTHAGIE QAISRGLAYA PYADLVWCET STPDLELARR
310 320 330 340 350
FADAIHAKYP GKLLAYNCSP SFNWQKNLDD KTIASFQQQL SDMGYKYQFI
360 370 380 390 400
TLAGIHSMWF NMFDLAHAYA QGEGMKHYVE KVQQPEFAAA KDGYTFVSHQ
410 420 430
QEVGTGYFDK VTTIIQGGAS SVTALTGSTE EAQF
Length:434
Mass (Da):47,563
Last modified:December 19, 2001 - v2
Checksum:i4ADC46FB4A4A5C60
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti390 – 3901A → G in strain: S3041.
Natural varianti392 – 3921D → E in strain: S3013, S3014, S3015, S3027 and S3041.
Natural varianti432 – 4321A → S in strain: S2978, S2979, S2980, S2983, S2985, S2993, S2995, S3013, S3014, S3015, S3027, S3041, S3044, S3057 and S3333.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL23008.1.
U43344 Genomic DNA. Translation: AAC43867.1.
U43345 Genomic DNA. Translation: AAC43869.1.
U43346 Genomic DNA. Translation: AAC43871.1.
U43347 Genomic DNA. Translation: AAC43872.1.
U43348 Genomic DNA. Translation: AAC43874.1.
U43349 Genomic DNA. Translation: AAC43876.1.
U43350 Genomic DNA. Translation: AAC43878.1.
U43351 Genomic DNA. Translation: AAC43880.1.
U43352 Genomic DNA. Translation: AAC43882.1.
U43353 Genomic DNA. Translation: AAC43884.1.
U43354 Genomic DNA. Translation: AAC43886.1.
U43355 Genomic DNA. Translation: AAC43888.1.
U43356 Genomic DNA. Translation: AAC43890.1.
U43357 Genomic DNA. Translation: AAC43892.1.
U43358 Genomic DNA. Translation: AAC43894.1.
U43359 Genomic DNA. Translation: AAC43896.1.
RefSeqiNP_463049.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL23008; AAL23008; STM4184.
GeneIDi1255710.
KEGGistm:STM4184.
PATRICi32387257. VBISalEnt20916_4396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL23008.1 .
U43344 Genomic DNA. Translation: AAC43867.1 .
U43345 Genomic DNA. Translation: AAC43869.1 .
U43346 Genomic DNA. Translation: AAC43871.1 .
U43347 Genomic DNA. Translation: AAC43872.1 .
U43348 Genomic DNA. Translation: AAC43874.1 .
U43349 Genomic DNA. Translation: AAC43876.1 .
U43350 Genomic DNA. Translation: AAC43878.1 .
U43351 Genomic DNA. Translation: AAC43880.1 .
U43352 Genomic DNA. Translation: AAC43882.1 .
U43353 Genomic DNA. Translation: AAC43884.1 .
U43354 Genomic DNA. Translation: AAC43886.1 .
U43355 Genomic DNA. Translation: AAC43888.1 .
U43356 Genomic DNA. Translation: AAC43890.1 .
U43357 Genomic DNA. Translation: AAC43892.1 .
U43358 Genomic DNA. Translation: AAC43894.1 .
U43359 Genomic DNA. Translation: AAC43896.1 .
RefSeqi NP_463049.1. NC_003197.1.

3D structure databases

ProteinModelPortali P51066.
SMRi P51066. Positions 2-417.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM4184.

Proteomic databases

PaxDbi P51066.
PRIDEi P51066.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL23008 ; AAL23008 ; STM4184 .
GeneIDi 1255710.
KEGGi stm:STM4184.
PATRICi 32387257. VBISalEnt20916_4396.

Phylogenomic databases

eggNOGi COG2224.
HOGENOMi HOG000238475.
KOi K01637.
OMAi DQIQWAN.
OrthoDBi EOG689HMX.
PhylomeDBi P51066.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .
BioCyci SENT99287:GCTI-4214-MONOMER.

Family and domain databases

Gene3Di 3.20.20.60. 1 hit.
InterProi IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfami PF00463. ICL. 1 hit.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR01346. isocit_lyase. 2 hits.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  2. "Size and sequence polymorphism in the isocitrate dehydrogenase kinase/phosphatase gene (aceK) and flanking regions in Salmonella enterica and Escherichia coli."
    Nelson K., Wang F.S., Boyd E.F., Selander R.K.
    Genetics 147:1509-1520(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 365-434.
    Strain: S2978, S2979, S2980, S2983, S2985, S2993, S2995, S3013, S3014, S3015, S3027, S3041, S3044, S3057, S3333 and S4194.

Entry informationi

Entry nameiACEA_SALTY
AccessioniPrimary (citable) accession number: P51066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 19, 2001
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3