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P51066

- ACEA_SALTY

UniProt

P51066 - ACEA_SALTY

Protein

Isocitrate lyase

Gene

aceA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (19 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase-positive serine pathway By similarity.By similarity

    Catalytic activityi

    Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

    Cofactori

    Divalent cations.

    Enzyme regulationi

    Is activated by phosphorylation (on histidine) and is inhibited by PEP, 3-phosphoglycerate and succinate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei195 – 1951PROSITE-ProRule annotation

    GO - Molecular functioni

    1. isocitrate lyase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-4214-MONOMER.
    UniPathwayiUPA00703; UER00719.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate lyase (EC:4.1.3.1)
    Short name:
    ICL
    Short name:
    Isocitrase
    Short name:
    Isocitratase
    Gene namesi
    Name:aceA
    Ordered Locus Names:STM4184
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Isocitrate lyasePRO_0000068776Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP51066.
    PRIDEiP51066.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi99287.STM4184.

    Structurei

    3D structure databases

    ProteinModelPortaliP51066.
    SMRiP51066. Positions 2-417.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2224.
    HOGENOMiHOG000238475.
    KOiK01637.
    OMAiDQIQWAN.
    OrthoDBiEOG689HMX.
    PhylomeDBiP51066.

    Family and domain databases

    Gene3Di3.20.20.60. 1 hit.
    InterProiIPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
    PfamiPF00463. ICL. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    TIGRFAMsiTIGR01346. isocit_lyase. 2 hits.
    PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51066-1 [UniParc]FASTAAdd to Basket

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    MKTRTQQIEE LQKEWTQPRW EGITRPYSAE EVVKLRGSVN PECTLAQLGA    50
    AKMWRLLHGE AKKGYINSLG ALTGGQALQQ AKAGIEAIYL SGWQVAADAN 100
    LASSMYPDQS LYPANSVPAV VDRINNTFRR ADQIQWASGI EPNDPRYVDY 150
    FLPIVADAEA GFGGVLNAFE LMKSMIEAGA AAVHFEDQLA SVKKCGHMGG 200
    KVLVPTQEAI QKLVAARLAA DVMGVPTLVI ARTDADAADL ITSDCDPYDS 250
    GFITGERTSE GFYRTHAGIE QAISRGLAYA PYADLVWCET STPDLELARR 300
    FADAIHAKYP GKLLAYNCSP SFNWQKNLDD KTIASFQQQL SDMGYKYQFI 350
    TLAGIHSMWF NMFDLAHAYA QGEGMKHYVE KVQQPEFAAA KDGYTFVSHQ 400
    QEVGTGYFDK VTTIIQGGAS SVTALTGSTE EAQF 434
    Length:434
    Mass (Da):47,563
    Last modified:December 19, 2001 - v2
    Checksum:i4ADC46FB4A4A5C60
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti390 – 3901A → G in strain: S3041.
    Natural varianti392 – 3921D → E in strain: S3013, S3014, S3015, S3027 and S3041.
    Natural varianti432 – 4321A → S in strain: S2978, S2979, S2980, S2983, S2985, S2993, S2995, S3013, S3014, S3015, S3027, S3041, S3044, S3057 and S3333.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL23008.1.
    U43344 Genomic DNA. Translation: AAC43867.1.
    U43345 Genomic DNA. Translation: AAC43869.1.
    U43346 Genomic DNA. Translation: AAC43871.1.
    U43347 Genomic DNA. Translation: AAC43872.1.
    U43348 Genomic DNA. Translation: AAC43874.1.
    U43349 Genomic DNA. Translation: AAC43876.1.
    U43350 Genomic DNA. Translation: AAC43878.1.
    U43351 Genomic DNA. Translation: AAC43880.1.
    U43352 Genomic DNA. Translation: AAC43882.1.
    U43353 Genomic DNA. Translation: AAC43884.1.
    U43354 Genomic DNA. Translation: AAC43886.1.
    U43355 Genomic DNA. Translation: AAC43888.1.
    U43356 Genomic DNA. Translation: AAC43890.1.
    U43357 Genomic DNA. Translation: AAC43892.1.
    U43358 Genomic DNA. Translation: AAC43894.1.
    U43359 Genomic DNA. Translation: AAC43896.1.
    RefSeqiNP_463049.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL23008; AAL23008; STM4184.
    GeneIDi1255710.
    KEGGistm:STM4184.
    PATRICi32387257. VBISalEnt20916_4396.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL23008.1 .
    U43344 Genomic DNA. Translation: AAC43867.1 .
    U43345 Genomic DNA. Translation: AAC43869.1 .
    U43346 Genomic DNA. Translation: AAC43871.1 .
    U43347 Genomic DNA. Translation: AAC43872.1 .
    U43348 Genomic DNA. Translation: AAC43874.1 .
    U43349 Genomic DNA. Translation: AAC43876.1 .
    U43350 Genomic DNA. Translation: AAC43878.1 .
    U43351 Genomic DNA. Translation: AAC43880.1 .
    U43352 Genomic DNA. Translation: AAC43882.1 .
    U43353 Genomic DNA. Translation: AAC43884.1 .
    U43354 Genomic DNA. Translation: AAC43886.1 .
    U43355 Genomic DNA. Translation: AAC43888.1 .
    U43356 Genomic DNA. Translation: AAC43890.1 .
    U43357 Genomic DNA. Translation: AAC43892.1 .
    U43358 Genomic DNA. Translation: AAC43894.1 .
    U43359 Genomic DNA. Translation: AAC43896.1 .
    RefSeqi NP_463049.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali P51066.
    SMRi P51066. Positions 2-417.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM4184.

    Proteomic databases

    PaxDbi P51066.
    PRIDEi P51066.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL23008 ; AAL23008 ; STM4184 .
    GeneIDi 1255710.
    KEGGi stm:STM4184.
    PATRICi 32387257. VBISalEnt20916_4396.

    Phylogenomic databases

    eggNOGi COG2224.
    HOGENOMi HOG000238475.
    KOi K01637.
    OMAi DQIQWAN.
    OrthoDBi EOG689HMX.
    PhylomeDBi P51066.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00719 .
    BioCyci SENT99287:GCTI-4214-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.60. 1 hit.
    InterProi IPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
    Pfami PF00463. ICL. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    TIGRFAMsi TIGR01346. isocit_lyase. 2 hits.
    PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.
    2. "Size and sequence polymorphism in the isocitrate dehydrogenase kinase/phosphatase gene (aceK) and flanking regions in Salmonella enterica and Escherichia coli."
      Nelson K., Wang F.S., Boyd E.F., Selander R.K.
      Genetics 147:1509-1520(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 365-434.
      Strain: S2978, S2979, S2980, S2983, S2985, S2993, S2995, S3013, S3014, S3015, S3027, S3041, S3044, S3057, S3333 and S4194.

    Entry informationi

    Entry nameiACEA_SALTY
    AccessioniPrimary (citable) accession number: P51066
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: December 19, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3