Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoenolpyruvate carboxykinase [ATP], glycosomal

Gene

PEPCK

Organism
Trypanosoma cruzi
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi221 – 228ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi4.1.1.49. 6524.
SABIO-RKP51058.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [ATP], glycosomal (EC:4.1.1.49)
Gene namesi
Name:PEPCK
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Glycosome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002038681 – 472Phosphoenolpyruvate carboxykinase [ATP], glycosomalAdd BLAST472

Proteomic databases

PaxDbiP51058.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi353153.XP_811627.1.

Structurei

Secondary structure

1472
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Helixi11 – 21Combined sources11
Beta strandi33 – 35Combined sources3
Beta strandi41 – 43Combined sources3
Helixi45 – 47Combined sources3
Beta strandi48 – 51Combined sources4
Helixi54 – 57Combined sources4
Turni63 – 65Combined sources3
Helixi71 – 86Combined sources16
Beta strandi88 – 98Combined sources11
Turni102 – 104Combined sources3
Beta strandi106 – 114Combined sources9
Helixi115 – 124Combined sources10
Helixi130 – 134Combined sources5
Beta strandi140 – 146Combined sources7
Beta strandi163 – 167Combined sources5
Turni168 – 171Combined sources4
Beta strandi172 – 177Combined sources6
Helixi182 – 198Combined sources17
Beta strandi202 – 210Combined sources9
Beta strandi216 – 220Combined sources5
Helixi227 – 231Combined sources5
Beta strandi236 – 242Combined sources7
Beta strandi244 – 246Combined sources3
Beta strandi251 – 254Combined sources4
Beta strandi256 – 261Combined sources6
Turni267 – 269Combined sources3
Helixi271 – 275Combined sources5
Beta strandi282 – 285Combined sources4
Turni290 – 292Combined sources3
Beta strandi307 – 311Combined sources5
Helixi312 – 314Combined sources3
Beta strandi327 – 334Combined sources8
Beta strandi343 – 347Combined sources5
Helixi349 – 358Combined sources10
Beta strandi360 – 363Combined sources4
Beta strandi365 – 368Combined sources4
Beta strandi376 – 379Combined sources4
Helixi381 – 383Combined sources3
Helixi385 – 387Combined sources3
Helixi392 – 406Combined sources15
Beta strandi409 – 414Combined sources6
Beta strandi416 – 420Combined sources5
Helixi422 – 424Combined sources3
Helixi431 – 442Combined sources12
Beta strandi443 – 445Combined sources3
Helixi446 – 448Combined sources3
Beta strandi451 – 454Combined sources4
Turni455 – 457Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1II2X-ray2.00A/B2-457[»]
ProteinModelPortaliP51058.
SMRiP51058.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51058.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IE0Y. Eukaryota.
COG1866. LUCA.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP. 1 hit.
InterProiIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view]
PfamiPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00532. PEPCK_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPTIHRNLL SPELVQWALK IEKDSRLTAR GALAVMSYAK TGRSPLDKRI
60 70 80 90 100
VDTDDVRENV DWGKVNMKLS EESFARVRKI AKEFLDTREH LFVVDCFAGH
110 120 130 140 150
DERYRLKVRV FTTRPYHALF MRDMLIVPTP EELATFGEPD YVIYNAGECK
160 170 180 190 200
ADPSIPGLTS TTCVALNFKT REQVILGTEY AGEMKKGILT VMFELMPQMN
210 220 230 240 250
HLCMHASANV GKQGDVTVFF GLSGTGKTTL SADPHRNLIG DDEHVWTDRG
260 270 280 290 300
VFNIEGGCYA KAIGLNPKTE KDIYDAVRFG AVAENCVLDK RTGEIDFYDE
310 320 330 340 350
SICKNTRVAY PLSHIEGALS KAIAGHPKNV IFLTNDAFGV MPPVARLTSA
360 370 380 390 400
QAMFWFVMGY TANVPGVEAG GTRTARPIFS SCFGGPFLVR HATFYGEQLA
410 420 430 440 450
EKMQKHNSRV WLLNTGYAGG RADRGAKRMP LRVTRAIIDA IHDGTLDRTE
460 470
YEEYPGWACT SRSTSPKCRS IC
Length:472
Mass (Da):52,585
Last modified:October 1, 1996 - v1
Checksum:iECD918DB3882CFE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91163 mRNA. Translation: AAA50780.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91163 mRNA. Translation: AAA50780.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1II2X-ray2.00A/B2-457[»]
ProteinModelPortaliP51058.
SMRiP51058.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi353153.XP_811627.1.

Proteomic databases

PaxDbiP51058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IE0Y. Eukaryota.
COG1866. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00138.
BRENDAi4.1.1.49. 6524.
SABIO-RKP51058.

Miscellaneous databases

EvolutionaryTraceiP51058.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP. 1 hit.
InterProiIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view]
PfamiPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00532. PEPCK_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCKA_TRYCR
AccessioniPrimary (citable) accession number: P51058
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.