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Protein

Phosphoenolpyruvate carboxykinase [ATP], glycosomal

Gene

PEPCK

Organism
Trypanosoma cruzi
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi221 – 2288ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi4.1.1.49. 6524.
SABIO-RKP51058.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [ATP], glycosomal (EC:4.1.1.49)
Gene namesi
Name:PEPCK
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Glycosome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Phosphoenolpyruvate carboxykinase [ATP], glycosomalPRO_0000203868Add
BLAST

Proteomic databases

PaxDbiP51058.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi353153.XP_811627.1.

Structurei

Secondary structure

1
472
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 85Combined sources
Helixi11 – 2111Combined sources
Beta strandi33 – 353Combined sources
Beta strandi41 – 433Combined sources
Helixi45 – 473Combined sources
Beta strandi48 – 514Combined sources
Helixi54 – 574Combined sources
Turni63 – 653Combined sources
Helixi71 – 8616Combined sources
Beta strandi88 – 9811Combined sources
Turni102 – 1043Combined sources
Beta strandi106 – 1149Combined sources
Helixi115 – 12410Combined sources
Helixi130 – 1345Combined sources
Beta strandi140 – 1467Combined sources
Beta strandi163 – 1675Combined sources
Turni168 – 1714Combined sources
Beta strandi172 – 1776Combined sources
Helixi182 – 19817Combined sources
Beta strandi202 – 2109Combined sources
Beta strandi216 – 2205Combined sources
Helixi227 – 2315Combined sources
Beta strandi236 – 2427Combined sources
Beta strandi244 – 2463Combined sources
Beta strandi251 – 2544Combined sources
Beta strandi256 – 2616Combined sources
Turni267 – 2693Combined sources
Helixi271 – 2755Combined sources
Beta strandi282 – 2854Combined sources
Turni290 – 2923Combined sources
Beta strandi307 – 3115Combined sources
Helixi312 – 3143Combined sources
Beta strandi327 – 3348Combined sources
Beta strandi343 – 3475Combined sources
Helixi349 – 35810Combined sources
Beta strandi360 – 3634Combined sources
Beta strandi365 – 3684Combined sources
Beta strandi376 – 3794Combined sources
Helixi381 – 3833Combined sources
Helixi385 – 3873Combined sources
Helixi392 – 40615Combined sources
Beta strandi409 – 4146Combined sources
Beta strandi416 – 4205Combined sources
Helixi422 – 4243Combined sources
Helixi431 – 44212Combined sources
Beta strandi443 – 4453Combined sources
Helixi446 – 4483Combined sources
Beta strandi451 – 4544Combined sources
Turni455 – 4573Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1II2X-ray2.00A/B2-457[»]
ProteinModelPortaliP51058.
SMRiP51058. Positions 2-458.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51058.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IE0Y. Eukaryota.
COG1866. LUCA.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP. 1 hit.
InterProiIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view]
PfamiPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00532. PEPCK_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPTIHRNLL SPELVQWALK IEKDSRLTAR GALAVMSYAK TGRSPLDKRI
60 70 80 90 100
VDTDDVRENV DWGKVNMKLS EESFARVRKI AKEFLDTREH LFVVDCFAGH
110 120 130 140 150
DERYRLKVRV FTTRPYHALF MRDMLIVPTP EELATFGEPD YVIYNAGECK
160 170 180 190 200
ADPSIPGLTS TTCVALNFKT REQVILGTEY AGEMKKGILT VMFELMPQMN
210 220 230 240 250
HLCMHASANV GKQGDVTVFF GLSGTGKTTL SADPHRNLIG DDEHVWTDRG
260 270 280 290 300
VFNIEGGCYA KAIGLNPKTE KDIYDAVRFG AVAENCVLDK RTGEIDFYDE
310 320 330 340 350
SICKNTRVAY PLSHIEGALS KAIAGHPKNV IFLTNDAFGV MPPVARLTSA
360 370 380 390 400
QAMFWFVMGY TANVPGVEAG GTRTARPIFS SCFGGPFLVR HATFYGEQLA
410 420 430 440 450
EKMQKHNSRV WLLNTGYAGG RADRGAKRMP LRVTRAIIDA IHDGTLDRTE
460 470
YEEYPGWACT SRSTSPKCRS IC
Length:472
Mass (Da):52,585
Last modified:October 1, 1996 - v1
Checksum:iECD918DB3882CFE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91163 mRNA. Translation: AAA50780.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91163 mRNA. Translation: AAA50780.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1II2X-ray2.00A/B2-457[»]
ProteinModelPortaliP51058.
SMRiP51058. Positions 2-458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi353153.XP_811627.1.

Proteomic databases

PaxDbiP51058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IE0Y. Eukaryota.
COG1866. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00138.
BRENDAi4.1.1.49. 6524.
SABIO-RKP51058.

Miscellaneous databases

EvolutionaryTraceiP51058.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP. 1 hit.
InterProiIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view]
PfamiPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00532. PEPCK_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCKA_TRYCR
AccessioniPrimary (citable) accession number: P51058
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 9, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.