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P51056

- ODO1_COXBU

UniProt

P51056 - ODO1_COXBU

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene
sucA, CBU_1399
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate.

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1387-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:CBU_1399
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9349342-oxoglutarate dehydrogenase E1 componentPRO_0000162190Add
BLAST

Proteomic databases

PRIDEiP51056.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi227377.CBU_1399.

Structurei

3D structure databases

ProteinModelPortaliP51056.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

P51056-1 [UniParc]FASTAAdd to Basket

« Hide

MPKITMQQFQ KNSYLADNNA GYIETLYENF LKDPHSVNEE WRSYFRTLTN    50
GASTPDISHA TIREEFRELA RKPRSISPTA ITPAAEQAAV DLLIEGYRRF 100
GHLNAKINPL GDNRPVDSRL ELGHYNLTES DFNKTFATYG LLNKPKATLK 150
EIYTRLREIY CGSIGVQYST ISDERERNWL RDYVEQRLPS IEFDKETKRN 200
ILQQLVTAES LEKYLDTKYV GQVRYSLEGG DSLIPLLDEL TKRARHQKIE 250
EIVICMAHRG RVNVLLNIMG QSAAELFQEF EGKKDYGLMS GDVKYHRGYS 300
RDVKTDAGPI HLSLAFNPSH LEFICPVAMG SVRARQERQN GHKRDYAMTV 350
MIHGDASFSG EGIVMEALSM SQTRAHHVGG SIHIILNNQV GFTTSNPHDA 400
RSSMYCSDIA KMLDAPVFHV NGDDPEAVVA VTQLALDYRM AFHKDVFIDL 450
VCYRRHGHQE VDDPMPTQPA MYKVIQEHPT TRTLYAKNLI EKKLCTAEEV 500
DQWIDDYRDR LDRGRQLVET LPEGLSAHYA ANWTPYLGQD WTTLVDTTLP 550
LKKLKALGKK FSTLPNTLHL HRKVEAIYKA RLEMAEGKTP MDWGFAEMLA 600
YASLLEEGFS VRLVGQDSRR GTFFHRHAVV FDQETGKEYE PLKHLSDKQA 650
APHIYDSLLC EAGALGFEYG YSTADPNSLV IWEAQFGDFA NVAQVIVDQF 700
ISSGWQKWNR LSGIVLFLPH GYEGKGPEHS SARLERYLQL CAQNNMQVCA 750
PTTPSQIFHL LRRQVLRPYR KPLVVLTPKS VLRNKLAVSS LEDLARGQLK 800
LLIPEIEKHD PKKITRVILC SGKVYYDLLA KRREHKGKLN HIAMIRIEQL 850
YPFPYDELKA ELEKYPNAKQ VIWCQEEPKN QGAWFCTRHR LIKCMRDDQT 900
LEYVGRSAFA APAAGYSALY VKLQEQLVNQ ALEI 934
Length:934
Mass (Da):106,723
Last modified:May 9, 2003 - v3
Checksum:i7FB8144F8E013E8D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti600 – 6001A → R in AAA61785. 1 Publication
Sequence conflicti614 – 63017VGQDS…RHAVV → SVKIPDEALFFIAMPLW in AAA61785. 1 PublicationAdd
BLAST
Sequence conflicti778 – 7825PKSVL → QKCA in AAA61785. 1 Publication
Sequence conflicti809 – 8168HDPKKITR → RIRKKSPA in AAA61785. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07789 Unassigned DNA. Translation: AAA61785.1.
X77919 Genomic DNA. Translation: CAA54874.1.
AE016828 Genomic DNA. Translation: AAO90898.1.
L33409 Genomic DNA. Translation: AAA74135.1.
PIRiS42874.
RefSeqiNP_820384.1. NC_002971.3.
WP_010958201.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90898; AAO90898; CBU_1399.
GeneIDi1209305.
KEGGicbu:CBU_1399.
PATRICi17931555. VBICoxBur82552_1401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07789 Unassigned DNA. Translation: AAA61785.1 .
X77919 Genomic DNA. Translation: CAA54874.1 .
AE016828 Genomic DNA. Translation: AAO90898.1 .
L33409 Genomic DNA. Translation: AAA74135.1 .
PIRi S42874.
RefSeqi NP_820384.1. NC_002971.3.
WP_010958201.1. NC_002971.3.

3D structure databases

ProteinModelPortali P51056.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1399.

Proteomic databases

PRIDEi P51056.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO90898 ; AAO90898 ; CBU_1399 .
GeneIDi 1209305.
KEGGi cbu:CBU_1399.
PATRICi 17931555. VBICoxBur82552_1401.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-1387-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Schimmels J.A., Mallavia L.P.
    Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Nine Mile.
  2. Thiele D., Willems H., Oswald W., Krauss H.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Nine Mile phase I.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.
  4. "Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii."
    Heinzen R.A., Mo Y.-Y., Robertson S.J., Mallavia L.P.
    Gene 155:27-34(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-280.
    Strain: Nine Mile.

Entry informationi

Entry nameiODO1_COXBU
AccessioniPrimary (citable) accession number: P51056
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 9, 2003
Last modified: September 3, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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