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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1387-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:CBU_1399
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9349342-oxoglutarate dehydrogenase E1 componentPRO_0000162190Add
BLAST

Proteomic databases

PRIDEiP51056.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi227377.CBU_1399.

Structurei

3D structure databases

ProteinModelPortaliP51056.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

P51056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKITMQQFQ KNSYLADNNA GYIETLYENF LKDPHSVNEE WRSYFRTLTN
60 70 80 90 100
GASTPDISHA TIREEFRELA RKPRSISPTA ITPAAEQAAV DLLIEGYRRF
110 120 130 140 150
GHLNAKINPL GDNRPVDSRL ELGHYNLTES DFNKTFATYG LLNKPKATLK
160 170 180 190 200
EIYTRLREIY CGSIGVQYST ISDERERNWL RDYVEQRLPS IEFDKETKRN
210 220 230 240 250
ILQQLVTAES LEKYLDTKYV GQVRYSLEGG DSLIPLLDEL TKRARHQKIE
260 270 280 290 300
EIVICMAHRG RVNVLLNIMG QSAAELFQEF EGKKDYGLMS GDVKYHRGYS
310 320 330 340 350
RDVKTDAGPI HLSLAFNPSH LEFICPVAMG SVRARQERQN GHKRDYAMTV
360 370 380 390 400
MIHGDASFSG EGIVMEALSM SQTRAHHVGG SIHIILNNQV GFTTSNPHDA
410 420 430 440 450
RSSMYCSDIA KMLDAPVFHV NGDDPEAVVA VTQLALDYRM AFHKDVFIDL
460 470 480 490 500
VCYRRHGHQE VDDPMPTQPA MYKVIQEHPT TRTLYAKNLI EKKLCTAEEV
510 520 530 540 550
DQWIDDYRDR LDRGRQLVET LPEGLSAHYA ANWTPYLGQD WTTLVDTTLP
560 570 580 590 600
LKKLKALGKK FSTLPNTLHL HRKVEAIYKA RLEMAEGKTP MDWGFAEMLA
610 620 630 640 650
YASLLEEGFS VRLVGQDSRR GTFFHRHAVV FDQETGKEYE PLKHLSDKQA
660 670 680 690 700
APHIYDSLLC EAGALGFEYG YSTADPNSLV IWEAQFGDFA NVAQVIVDQF
710 720 730 740 750
ISSGWQKWNR LSGIVLFLPH GYEGKGPEHS SARLERYLQL CAQNNMQVCA
760 770 780 790 800
PTTPSQIFHL LRRQVLRPYR KPLVVLTPKS VLRNKLAVSS LEDLARGQLK
810 820 830 840 850
LLIPEIEKHD PKKITRVILC SGKVYYDLLA KRREHKGKLN HIAMIRIEQL
860 870 880 890 900
YPFPYDELKA ELEKYPNAKQ VIWCQEEPKN QGAWFCTRHR LIKCMRDDQT
910 920 930
LEYVGRSAFA APAAGYSALY VKLQEQLVNQ ALEI
Length:934
Mass (Da):106,723
Last modified:May 9, 2003 - v3
Checksum:i7FB8144F8E013E8D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti600 – 6001A → R in AAA61785 (Ref. 1) Curated
Sequence conflicti614 – 63017VGQDS…RHAVV → SVKIPDEALFFIAMPLW in AAA61785 (Ref. 1) CuratedAdd
BLAST
Sequence conflicti778 – 7825PKSVL → QKCA in AAA61785 (Ref. 1) Curated
Sequence conflicti809 – 8168HDPKKITR → RIRKKSPA in AAA61785 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07789 Unassigned DNA. Translation: AAA61785.1.
X77919 Genomic DNA. Translation: CAA54874.1.
AE016828 Genomic DNA. Translation: AAO90898.1.
L33409 Genomic DNA. Translation: AAA74135.1.
PIRiS42874.
RefSeqiNP_820384.1. NC_002971.3.
WP_010958201.1. NZ_CCNR01000027.1.

Genome annotation databases

EnsemblBacteriaiAAO90898; AAO90898; CBU_1399.
GeneIDi1209305.
KEGGicbu:CBU_1399.
PATRICi17931555. VBICoxBur82552_1401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07789 Unassigned DNA. Translation: AAA61785.1.
X77919 Genomic DNA. Translation: CAA54874.1.
AE016828 Genomic DNA. Translation: AAO90898.1.
L33409 Genomic DNA. Translation: AAA74135.1.
PIRiS42874.
RefSeqiNP_820384.1. NC_002971.3.
WP_010958201.1. NZ_CCNR01000027.1.

3D structure databases

ProteinModelPortaliP51056.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_1399.

Proteomic databases

PRIDEiP51056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO90898; AAO90898; CBU_1399.
GeneIDi1209305.
KEGGicbu:CBU_1399.
PATRICi17931555. VBICoxBur82552_1401.

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1387-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Schimmels J.A., Mallavia L.P.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Nine Mile.
  2. Thiele D., Willems H., Oswald W., Krauss H.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Nine Mile phase I.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.
  4. "Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii."
    Heinzen R.A., Mo Y.-Y., Robertson S.J., Mallavia L.P.
    Gene 155:27-34(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-280.
    Strain: Nine Mile.

Entry informationi

Entry nameiODO1_COXBU
AccessioniPrimary (citable) accession number: P51056
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 9, 2003
Last modified: January 7, 2015
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.