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P51056 (ODO1_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component

EC=1.2.4.2
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene names
Name:sucA
Ordered Locus Names:CBU_1399
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length934 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9349342-oxoglutarate dehydrogenase E1 component
PRO_0000162190

Experimental info

Sequence conflict6001A → R in AAA61785. Ref.1
Sequence conflict614 – 63017VGQDS…RHAVV → SVKIPDEALFFIAMPLW in AAA61785. Ref.1
Sequence conflict778 – 7825PKSVL → QKCA in AAA61785. Ref.1
Sequence conflict809 – 8168HDPKKITR → RIRKKSPA in AAA61785. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P51056 [UniParc].

Last modified May 9, 2003. Version 3.
Checksum: 7FB8144F8E013E8D

FASTA934106,723
        10         20         30         40         50         60 
MPKITMQQFQ KNSYLADNNA GYIETLYENF LKDPHSVNEE WRSYFRTLTN GASTPDISHA 

        70         80         90        100        110        120 
TIREEFRELA RKPRSISPTA ITPAAEQAAV DLLIEGYRRF GHLNAKINPL GDNRPVDSRL 

       130        140        150        160        170        180 
ELGHYNLTES DFNKTFATYG LLNKPKATLK EIYTRLREIY CGSIGVQYST ISDERERNWL 

       190        200        210        220        230        240 
RDYVEQRLPS IEFDKETKRN ILQQLVTAES LEKYLDTKYV GQVRYSLEGG DSLIPLLDEL 

       250        260        270        280        290        300 
TKRARHQKIE EIVICMAHRG RVNVLLNIMG QSAAELFQEF EGKKDYGLMS GDVKYHRGYS 

       310        320        330        340        350        360 
RDVKTDAGPI HLSLAFNPSH LEFICPVAMG SVRARQERQN GHKRDYAMTV MIHGDASFSG 

       370        380        390        400        410        420 
EGIVMEALSM SQTRAHHVGG SIHIILNNQV GFTTSNPHDA RSSMYCSDIA KMLDAPVFHV 

       430        440        450        460        470        480 
NGDDPEAVVA VTQLALDYRM AFHKDVFIDL VCYRRHGHQE VDDPMPTQPA MYKVIQEHPT 

       490        500        510        520        530        540 
TRTLYAKNLI EKKLCTAEEV DQWIDDYRDR LDRGRQLVET LPEGLSAHYA ANWTPYLGQD 

       550        560        570        580        590        600 
WTTLVDTTLP LKKLKALGKK FSTLPNTLHL HRKVEAIYKA RLEMAEGKTP MDWGFAEMLA 

       610        620        630        640        650        660 
YASLLEEGFS VRLVGQDSRR GTFFHRHAVV FDQETGKEYE PLKHLSDKQA APHIYDSLLC 

       670        680        690        700        710        720 
EAGALGFEYG YSTADPNSLV IWEAQFGDFA NVAQVIVDQF ISSGWQKWNR LSGIVLFLPH 

       730        740        750        760        770        780 
GYEGKGPEHS SARLERYLQL CAQNNMQVCA PTTPSQIFHL LRRQVLRPYR KPLVVLTPKS 

       790        800        810        820        830        840 
VLRNKLAVSS LEDLARGQLK LLIPEIEKHD PKKITRVILC SGKVYYDLLA KRREHKGKLN 

       850        860        870        880        890        900 
HIAMIRIEQL YPFPYDELKA ELEKYPNAKQ VIWCQEEPKN QGAWFCTRHR LIKCMRDDQT 

       910        920        930 
LEYVGRSAFA APAAGYSALY VKLQEQLVNQ ALEI 

« Hide

References

« Hide 'large scale' references
[1]Schimmels J.A., Mallavia L.P.
Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Nine Mile.
[2]Thiele D., Willems H., Oswald W., Krauss H.
Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Nine Mile phase I.
[3]"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii."
Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. expand/collapse author list , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F.
Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RSA 493 / Nine Mile phase I.
[4]"Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii."
Heinzen R.A., Mo Y.-Y., Robertson S.J., Mallavia L.P.
Gene 155:27-34(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-280.
Strain: Nine Mile.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U07789 Unassigned DNA. Translation: AAA61785.1.
X77919 Genomic DNA. Translation: CAA54874.1.
AE016828 Genomic DNA. Translation: AAO90898.1.
L33409 Genomic DNA. Translation: AAA74135.1.
PIRS42874.
RefSeqNP_820384.1. NC_002971.3.

3D structure databases

ProteinModelPortalP51056.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_1399.

Proteomic databases

PRIDEP51056.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO90898; AAO90898; CBU_1399.
GeneID1209305.
KEGGcbu:CBU_1399.
PATRIC17931555. VBICoxBur82552_1401.

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
KOK00164.
OMAGHQNANL.
OrthoDBEOG6V1M1F.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-1387-MONOMER.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_COXBU
AccessionPrimary (citable) accession number: P51056
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 9, 2003
Last modified: June 11, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names