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P51054

- SDHA_COXBU

UniProt

P51054 - SDHA_COXBU

Protein

Succinate dehydrogenase flavoprotein subunit

Gene

sdhA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    FAD.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei223 – 2231FADBy similarity
    Binding sitei244 – 2441SubstrateBy similarity
    Binding sitei256 – 2561SubstrateBy similarity
    Active sitei288 – 2881Proton acceptorBy similarity
    Binding sitei355 – 3551SubstrateBy similarity
    Binding sitei389 – 3891FADBy similarity
    Binding sitei400 – 4001SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 206FADBy similarity
    Nucleotide bindingi39 – 5416FADBy similarityAdd
    BLAST
    Nucleotide bindingi405 – 4062FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-1389-MONOMER.
    UniPathwayiUPA00223; UER01005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1)
    Gene namesi
    Name:sdhA
    Ordered Locus Names:CBU_1401
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cell inner membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 587587Succinate dehydrogenase flavoprotein subunitPRO_0000158651Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei47 – 471Tele-8alpha-FAD histidineBy similarity

    Proteomic databases

    PRIDEiP51054.

    Interactioni

    Subunit structurei

    Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, cytochrome b-556 and a hydrophobic protein.

    Protein-protein interaction databases

    STRINGi227377.CBU_1401.

    Structurei

    3D structure databases

    ProteinModelPortaliP51054.
    SMRiP51054. Positions 6-586.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1053.
    HOGENOMiHOG000160475.
    KOiK00239.
    OMAiRTEQGRI.
    OrthoDBiEOG6M3PC4.

    Family and domain databases

    Gene3Di1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProiIPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view]
    PfamiPF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51054-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSIRVKQYD ALIVGAGGAG LRAALEMAQS RQYKVAVVSK VFPTRSHTVS    50
    AQGGIAAALG NVVPDKPIWH MFDTVKGSDY LGDQDAIQYM CEQAPPSVYE 100
    LEHYGLPFSR LDDGRIYQRA FGGHTRDFGK EMARRTCACA DRTGHAMLHT 150
    LYQKNVEAGT HFYYEWYGID LVRGAQGGIA GMIAMNMETS ELVFFKSRAT 200
    IFATGGAGRI YETTSNAYTN TGDGIGMVLR AGLPVQDMEF WQFHPTGIYG 250
    VGCLITEGAR GEGGYLINKD GERFMERYSP HLKDLDCRDV VARSILQEVM 300
    AGGGVGPKKD HVLLKLDHLG EKVLRERLPG IIELSEKFAN VDITKEPIPI 350
    LPTCHYMMGG IPTNIHGQAL TVDENGKDQI IEGLFAAGEC ACVSVHGANR 400
    LGTNSLLDLV VFGRAIGLHL EEALKTELKH RSENPDDIDA AIARLKRWEK 450
    PNNVENPALL RQEMRKAMSE DFGVFREEQK MKQGLERLQK LNERLQRAKL 500
    TDTSRTFNNA RIEALELDNL MEVSYATAVS AQQRTESRGA HSRYDYKERD 550
    DANWLKHTVY FRDGHIAYRP VNMKPKGMDP FPPKSRD 587
    Length:587
    Mass (Da):65,438
    Last modified:October 1, 1996 - v1
    Checksum:i37B264ECC98D3DB6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33409 Genomic DNA. Translation: AAA74133.1.
    AE016828 Genomic DNA. Translation: AAO90900.1.
    PIRiI40849.
    RefSeqiNP_820386.1. NC_002971.3.
    WP_010958202.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO90900; AAO90900; CBU_1401.
    GeneIDi1209307.
    KEGGicbu:CBU_1401.
    PATRICi17931559. VBICoxBur82552_1403.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33409 Genomic DNA. Translation: AAA74133.1 .
    AE016828 Genomic DNA. Translation: AAO90900.1 .
    PIRi I40849.
    RefSeqi NP_820386.1. NC_002971.3.
    WP_010958202.1. NC_002971.3.

    3D structure databases

    ProteinModelPortali P51054.
    SMRi P51054. Positions 6-586.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_1401.

    Proteomic databases

    PRIDEi P51054.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO90900 ; AAO90900 ; CBU_1401 .
    GeneIDi 1209307.
    KEGGi cbu:CBU_1401.
    PATRICi 17931559. VBICoxBur82552_1403.

    Phylogenomic databases

    eggNOGi COG1053.
    HOGENOMi HOG000160475.
    KOi K00239.
    OMAi RTEQGRI.
    OrthoDBi EOG6M3PC4.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01005 .
    BioCyci CBUR227377:GJ7S-1389-MONOMER.

    Family and domain databases

    Gene3Di 1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProi IPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view ]
    Pfami PF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii."
      Heinzen R.A., Mo Y.-Y., Robertson S.J., Mallavia L.P.
      Gene 155:27-34(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Nine Mile.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiSDHA_COXBU
    AccessioniPrimary (citable) accession number: P51054
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3