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Protein

Succinate dehydrogenase flavoprotein subunit

Gene

sdhA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Pathway:itricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (bacterial route).
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase flavoprotein subunit (sdhA), Succinate dehydrogenase iron-sulfur subunit (sdhB)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (bacterial route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei223 – 2231FADBy similarity
Binding sitei244 – 2441SubstrateBy similarity
Binding sitei256 – 2561SubstrateBy similarity
Active sitei288 – 2881Proton acceptorBy similarity
Binding sitei355 – 3551SubstrateBy similarity
Binding sitei389 – 3891FADBy similarity
Binding sitei400 – 4001SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 206FADBy similarity
Nucleotide bindingi39 – 5416FADBy similarityAdd
BLAST
Nucleotide bindingi405 – 4062FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1389-MONOMER.
UniPathwayiUPA00223; UER01005.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1)
Gene namesi
Name:sdhA
Ordered Locus Names:CBU_1401
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Succinate dehydrogenase flavoprotein subunitPRO_0000158651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471Tele-8alpha-FAD histidineBy similarity

Proteomic databases

PRIDEiP51054.

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, cytochrome b-556 and a hydrophobic protein.

Protein-protein interaction databases

STRINGi227377.CBU_1401.

Structurei

3D structure databases

ProteinModelPortaliP51054.
SMRiP51054. Positions 6-586.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1053.
HOGENOMiHOG000160475.
KOiK00239.
OMAiKWRTCFT.
OrthoDBiEOG6M3PC4.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIRVKQYD ALIVGAGGAG LRAALEMAQS RQYKVAVVSK VFPTRSHTVS
60 70 80 90 100
AQGGIAAALG NVVPDKPIWH MFDTVKGSDY LGDQDAIQYM CEQAPPSVYE
110 120 130 140 150
LEHYGLPFSR LDDGRIYQRA FGGHTRDFGK EMARRTCACA DRTGHAMLHT
160 170 180 190 200
LYQKNVEAGT HFYYEWYGID LVRGAQGGIA GMIAMNMETS ELVFFKSRAT
210 220 230 240 250
IFATGGAGRI YETTSNAYTN TGDGIGMVLR AGLPVQDMEF WQFHPTGIYG
260 270 280 290 300
VGCLITEGAR GEGGYLINKD GERFMERYSP HLKDLDCRDV VARSILQEVM
310 320 330 340 350
AGGGVGPKKD HVLLKLDHLG EKVLRERLPG IIELSEKFAN VDITKEPIPI
360 370 380 390 400
LPTCHYMMGG IPTNIHGQAL TVDENGKDQI IEGLFAAGEC ACVSVHGANR
410 420 430 440 450
LGTNSLLDLV VFGRAIGLHL EEALKTELKH RSENPDDIDA AIARLKRWEK
460 470 480 490 500
PNNVENPALL RQEMRKAMSE DFGVFREEQK MKQGLERLQK LNERLQRAKL
510 520 530 540 550
TDTSRTFNNA RIEALELDNL MEVSYATAVS AQQRTESRGA HSRYDYKERD
560 570 580
DANWLKHTVY FRDGHIAYRP VNMKPKGMDP FPPKSRD
Length:587
Mass (Da):65,438
Last modified:October 1, 1996 - v1
Checksum:i37B264ECC98D3DB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33409 Genomic DNA. Translation: AAA74133.1.
AE016828 Genomic DNA. Translation: AAO90900.1.
PIRiI40849.
RefSeqiNP_820386.1. NC_002971.3.
WP_010958202.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90900; AAO90900; CBU_1401.
GeneIDi1209307.
KEGGicbu:CBU_1401.
PATRICi17931559. VBICoxBur82552_1403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33409 Genomic DNA. Translation: AAA74133.1.
AE016828 Genomic DNA. Translation: AAO90900.1.
PIRiI40849.
RefSeqiNP_820386.1. NC_002971.3.
WP_010958202.1. NC_002971.3.

3D structure databases

ProteinModelPortaliP51054.
SMRiP51054. Positions 6-586.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_1401.

Proteomic databases

PRIDEiP51054.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO90900; AAO90900; CBU_1401.
GeneIDi1209307.
KEGGicbu:CBU_1401.
PATRICi17931559. VBICoxBur82552_1403.

Phylogenomic databases

eggNOGiCOG1053.
HOGENOMiHOG000160475.
KOiK00239.
OMAiKWRTCFT.
OrthoDBiEOG6M3PC4.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01005.
BioCyciCBUR227377:GJ7S-1389-MONOMER.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii."
    Heinzen R.A., Mo Y.-Y., Robertson S.J., Mallavia L.P.
    Gene 155:27-34(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Nine Mile.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiSDHA_COXBU
AccessioniPrimary (citable) accession number: P51054
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 27, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.