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P51054

- SDHA_COXBU

UniProt

P51054 - SDHA_COXBU

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Protein
Succinate dehydrogenase flavoprotein subunit
Gene
sdhA, CBU_1401
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FAD.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei223 – 2231FAD By similarity
Binding sitei244 – 2441Substrate By similarity
Binding sitei256 – 2561Substrate By similarity
Active sitei288 – 2881Proton acceptor By similarity
Binding sitei355 – 3551Substrate By similarity
Binding sitei389 – 3891FAD By similarity
Binding sitei400 – 4001Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 206FAD By similarity
Nucleotide bindingi39 – 5416FAD By similarity
Add
BLAST
Nucleotide bindingi405 – 4062FAD By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1389-MONOMER.
UniPathwayiUPA00223; UER01005.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1)
Gene namesi
Name:sdhA
Ordered Locus Names:CBU_1401
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Succinate dehydrogenase flavoprotein subunit
PRO_0000158651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471Tele-8alpha-FAD histidine By similarity

Proteomic databases

PRIDEiP51054.

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, cytochrome b-556 and a hydrophobic protein.

Protein-protein interaction databases

STRINGi227377.CBU_1401.

Structurei

3D structure databases

ProteinModelPortaliP51054.
SMRiP51054. Positions 6-586.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1053.
HOGENOMiHOG000160475.
KOiK00239.
OMAiRTEQGRI.
OrthoDBiEOG6M3PC4.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51054-1 [UniParc]FASTAAdd to Basket

« Hide

MSSIRVKQYD ALIVGAGGAG LRAALEMAQS RQYKVAVVSK VFPTRSHTVS    50
AQGGIAAALG NVVPDKPIWH MFDTVKGSDY LGDQDAIQYM CEQAPPSVYE 100
LEHYGLPFSR LDDGRIYQRA FGGHTRDFGK EMARRTCACA DRTGHAMLHT 150
LYQKNVEAGT HFYYEWYGID LVRGAQGGIA GMIAMNMETS ELVFFKSRAT 200
IFATGGAGRI YETTSNAYTN TGDGIGMVLR AGLPVQDMEF WQFHPTGIYG 250
VGCLITEGAR GEGGYLINKD GERFMERYSP HLKDLDCRDV VARSILQEVM 300
AGGGVGPKKD HVLLKLDHLG EKVLRERLPG IIELSEKFAN VDITKEPIPI 350
LPTCHYMMGG IPTNIHGQAL TVDENGKDQI IEGLFAAGEC ACVSVHGANR 400
LGTNSLLDLV VFGRAIGLHL EEALKTELKH RSENPDDIDA AIARLKRWEK 450
PNNVENPALL RQEMRKAMSE DFGVFREEQK MKQGLERLQK LNERLQRAKL 500
TDTSRTFNNA RIEALELDNL MEVSYATAVS AQQRTESRGA HSRYDYKERD 550
DANWLKHTVY FRDGHIAYRP VNMKPKGMDP FPPKSRD 587
Length:587
Mass (Da):65,438
Last modified:October 1, 1996 - v1
Checksum:i37B264ECC98D3DB6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33409 Genomic DNA. Translation: AAA74133.1.
AE016828 Genomic DNA. Translation: AAO90900.1.
PIRiI40849.
RefSeqiNP_820386.1. NC_002971.3.
WP_010958202.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90900; AAO90900; CBU_1401.
GeneIDi1209307.
KEGGicbu:CBU_1401.
PATRICi17931559. VBICoxBur82552_1403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33409 Genomic DNA. Translation: AAA74133.1 .
AE016828 Genomic DNA. Translation: AAO90900.1 .
PIRi I40849.
RefSeqi NP_820386.1. NC_002971.3.
WP_010958202.1. NC_002971.3.

3D structure databases

ProteinModelPortali P51054.
SMRi P51054. Positions 6-586.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1401.

Proteomic databases

PRIDEi P51054.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO90900 ; AAO90900 ; CBU_1401 .
GeneIDi 1209307.
KEGGi cbu:CBU_1401.
PATRICi 17931559. VBICoxBur82552_1403.

Phylogenomic databases

eggNOGi COG1053.
HOGENOMi HOG000160475.
KOi K00239.
OMAi RTEQGRI.
OrthoDBi EOG6M3PC4.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01005 .
BioCyci CBUR227377:GJ7S-1389-MONOMER.

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii."
    Heinzen R.A., Mo Y.-Y., Robertson S.J., Mallavia L.P.
    Gene 155:27-34(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Nine Mile.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiSDHA_COXBU
AccessioniPrimary (citable) accession number: P51054
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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