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P51054 (SDHA_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase flavoprotein subunit

EC=1.3.5.1
Gene names
Name:sdhA
Ordered Locus Names:CBU_1401
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

FAD.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.

Subunit structure

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, cytochrome b-556 and a hydrophobic protein.

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 587587Succinate dehydrogenase flavoprotein subunit
PRO_0000158651

Regions

Nucleotide binding15 – 206FAD By similarity
Nucleotide binding39 – 5416FAD By similarity
Nucleotide binding405 – 4062FAD By similarity

Sites

Active site2881Proton acceptor By similarity
Binding site2231FAD By similarity
Binding site2441Substrate By similarity
Binding site2561Substrate By similarity
Binding site3551Substrate By similarity
Binding site3891FAD By similarity
Binding site4001Substrate By similarity

Amino acid modifications

Modified residue471Tele-8alpha-FAD histidine By similarity

Sequences

Sequence LengthMass (Da)Tools
P51054 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 37B264ECC98D3DB6

FASTA58765,438
        10         20         30         40         50         60 
MSSIRVKQYD ALIVGAGGAG LRAALEMAQS RQYKVAVVSK VFPTRSHTVS AQGGIAAALG 

        70         80         90        100        110        120 
NVVPDKPIWH MFDTVKGSDY LGDQDAIQYM CEQAPPSVYE LEHYGLPFSR LDDGRIYQRA 

       130        140        150        160        170        180 
FGGHTRDFGK EMARRTCACA DRTGHAMLHT LYQKNVEAGT HFYYEWYGID LVRGAQGGIA 

       190        200        210        220        230        240 
GMIAMNMETS ELVFFKSRAT IFATGGAGRI YETTSNAYTN TGDGIGMVLR AGLPVQDMEF 

       250        260        270        280        290        300 
WQFHPTGIYG VGCLITEGAR GEGGYLINKD GERFMERYSP HLKDLDCRDV VARSILQEVM 

       310        320        330        340        350        360 
AGGGVGPKKD HVLLKLDHLG EKVLRERLPG IIELSEKFAN VDITKEPIPI LPTCHYMMGG 

       370        380        390        400        410        420 
IPTNIHGQAL TVDENGKDQI IEGLFAAGEC ACVSVHGANR LGTNSLLDLV VFGRAIGLHL 

       430        440        450        460        470        480 
EEALKTELKH RSENPDDIDA AIARLKRWEK PNNVENPALL RQEMRKAMSE DFGVFREEQK 

       490        500        510        520        530        540 
MKQGLERLQK LNERLQRAKL TDTSRTFNNA RIEALELDNL MEVSYATAVS AQQRTESRGA 

       550        560        570        580 
HSRYDYKERD DANWLKHTVY FRDGHIAYRP VNMKPKGMDP FPPKSRD 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii."
Heinzen R.A., Mo Y.-Y., Robertson S.J., Mallavia L.P.
Gene 155:27-34(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Nine Mile.
[2]"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii."
Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. expand/collapse author list , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F.
Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RSA 493 / Nine Mile phase I.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L33409 Genomic DNA. Translation: AAA74133.1.
AE016828 Genomic DNA. Translation: AAO90900.1.
PIRI40849.
RefSeqNP_820386.1. NC_002971.3.

3D structure databases

ProteinModelPortalP51054.
SMRP51054. Positions 6-586.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_1401.

Proteomic databases

PRIDEP51054.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO90900; AAO90900; CBU_1401.
GeneID1209307.
KEGGcbu:CBU_1401.
PATRIC17931559. VBICoxBur82552_1403.

Phylogenomic databases

eggNOGCOG1053.
HOGENOMHOG000160475.
KOK00239.
OMAINVFGKR.
OrthoDBEOG6M3PC4.
ProtClustDBCLSK914756.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-1389-MONOMER.
UniPathwayUPA00223; UER01005.

Family and domain databases

Gene3D1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHA_COXBU
AccessionPrimary (citable) accession number: P51054
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names