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Reviewed, UniProtKB/Swiss-Prot P51053 (DHSB_COXBU)

Last modified November 25, 2008. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Succinate dehydrogenase iron-sulfur subunit
    EC=1.3.99.1
Gene names
Name: sdhB
Ordered Locus Names: CBU_1400
OrganismCoxiella burnetii [Complete proteome] [HAMAP]
Taxonomic identifier777 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Succinate + acceptor = fumarate + reduced acceptor.

Cofactor

Binds 1 2Fe-2S cluster.

Binds 1 3Fe-4S cluster.

Binds 1 4Fe-4S cluster.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle.

Subunit structure

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, cytochrome b-556 and a hydrophobic protein.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Succinate dehydrogenase iron-sulfur subunit
PRO_0000158687

Regions

Domain133 – 163314Fe-4S ferredoxin-type

Sites

Metal binding531Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding581Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding611Iron-sulfur 1 (2Fe-2S) Potential
Metal binding731Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1431Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1461Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1491Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1531Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2001Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2061Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2101Iron-sulfur 2 (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
P51053-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 5949664A63BF5B41

FASTA23526,847
        10         20         30         40         50         60 
MTFSIMRFNP ETDKKPYMQD FELDVSAIQG KMLLNALEAL REKHPDIGLR RSCAEGVCGS 

        70         80         90        100        110        120 
DGMNINGKNA LACVTQLKDL PDRVVVRPLP GFPIIRDLIV DMEQFYAQYK KVKPYLLNDQ 

       130        140        150        160        170        180 
EAPQKERLQS PEERAKLDGL YECILCACCS SSCPSYWWNP DKFIGPAGLL WSYRFIADSR 

       190        200        210        220        230 
DSKEKERLDA MKDPYSVFRC RTIMDCATVC PKNLNPAKAI RKIRTEMLQE TESGE 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii."
Heinzen R.A., Mo Y.-Y., Robertson S.J., Mallavia L.P.
Gene 155:27-34(1995) [PubMed: 7698664] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Nine Mile.
[2]Thiele D., Willems H., Oswald W., Krauss H.
Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Nine Mile.
[3]"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii."
Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. expand/collapse author list , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F.
Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nine Mile phase I / RSA 493.

Cross-references

Sequence databases

L33409 Genomic DNA. Translation: AAA74134.1.
X77919 Genomic DNA. Translation: CAA54873.1. Different initiation.
AE016828 Genomic DNA. Translation: AAO90899.1. Different initiation.
PIRS42873.
RefSeqNP_820385.1.

3D structure databases

HSSPHSSP built from PDB template 1NEK based on UniProtKB P07014.
ModBaseSearch...

Genome annotation databases

GeneID1209306.
GenomeReviewsGene locus CBU_1400 in contig AE016828_GR.
KEGGcbu:CBU_1400.
NMPDRfig|227377.1.peg.1329.
TIGRCBU_1400.

Phylogenomic databases

HOGENOMP51053.

Enzyme and pathway databases

BioCycCBUR227377:CBU_1400-MON.

Family and domain databases

InterProIPR001450. 4Fe4S_Fe_S_bd.
IPR014979. Acetone_carboxylase_gsu-rel.
IPR012675. b-grasp_ferredoxin-like.
IPR001041. Ferredoxin.
IPR012285. Fum_reductase_C.
IPR004489. Succ_DHase/fum_Rdtase_Fe-S.
[Graphical view]
Gene3DG3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
G3DSA:1.10.1060.10. Fum_reductase_C. 1 hit.
PfamPF08882. Acetone_carb_G. 1 hit.
PF00111. Fer2. 1 hit.
[Graphical view]
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHSB_COXBU
AccessionPrimary (citable) accession number: P51053
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 25, 2008
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents