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P51053 (SDHB_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase iron-sulfur subunit

EC=1.3.5.1
Gene names
Name:sdhB
Ordered Locus Names:CBU_1400
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster.

Binds 1 3Fe-4S cluster.

Binds 1 4Fe-4S cluster.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.

Subunit structure

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, cytochrome b-556 and a hydrophobic protein.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence caution

The sequence AAO90899.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAA54873.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Succinate dehydrogenase iron-sulfur subunit
PRO_0000158687

Regions

Domain133 – 163314Fe-4S ferredoxin-type

Sites

Metal binding531Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding581Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding731Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1431Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1461Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1491Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1531Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2001Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2061Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2101Iron-sulfur 2 (4Fe-4S) By similarity
Binding site1581Ubiquinone; shared with SdhD subunit By similarity

Sequences

Sequence LengthMass (Da)Tools
P51053 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 5949664A63BF5B41

FASTA23526,847
        10         20         30         40         50         60 
MTFSIMRFNP ETDKKPYMQD FELDVSAIQG KMLLNALEAL REKHPDIGLR RSCAEGVCGS 

        70         80         90        100        110        120 
DGMNINGKNA LACVTQLKDL PDRVVVRPLP GFPIIRDLIV DMEQFYAQYK KVKPYLLNDQ 

       130        140        150        160        170        180 
EAPQKERLQS PEERAKLDGL YECILCACCS SSCPSYWWNP DKFIGPAGLL WSYRFIADSR 

       190        200        210        220        230 
DSKEKERLDA MKDPYSVFRC RTIMDCATVC PKNLNPAKAI RKIRTEMLQE TESGE 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii."
Heinzen R.A., Mo Y.-Y., Robertson S.J., Mallavia L.P.
Gene 155:27-34(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Nine Mile.
[2]Thiele D., Willems H., Oswald W., Krauss H.
Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Nine Mile.
[3]"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii."
Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. expand/collapse author list , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F.
Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RSA 493 / Nine Mile phase I.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L33409 Genomic DNA. Translation: AAA74134.1.
X77919 Genomic DNA. Translation: CAA54873.1. Different initiation.
AE016828 Genomic DNA. Translation: AAO90899.1. Different initiation.
PIRS42873.
RefSeqNP_820385.1. NC_002971.3.

3D structure databases

ProteinModelPortalP51053.
SMRP51053. Positions 1-229.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_1400.

Proteomic databases

PRIDEP51053.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO90899; AAO90899; CBU_1400.
GeneID1209306.
KEGGcbu:CBU_1400.
PATRIC17931557. VBICoxBur82552_1402.

Phylogenomic databases

eggNOGCOG0479.
HOGENOMHOG000160590.
KOK00240.
OMAQYEKIRP.
OrthoDBEOG6CK7MG.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-1388-MONOMER.
UniPathwayUPA00223; UER01005.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHB_COXBU
AccessionPrimary (citable) accession number: P51053
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names