Succinate dehydrogenase iron-sulfur subunit

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P51053 (DHSB_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 84. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Succinate dehydrogenase iron-sulfur subunit
EC=1.3.99.1

Gene names

Name:	sdhB
Ordered Locus Names:	CBU_1400

Organism

Coxiella burnetii

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Succinate + acceptor = fumarate + reduced acceptor.
Cofactor	Binds 1 2Fe-2S cluster. Binds 1 3Fe-4S cluster. Binds 1 4Fe-4S cluster.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.
Subunit structure	Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, cytochrome b-556 and a hydrophobic protein.
Sequence similarities	Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. Contains 1 4Fe-4S ferredoxin-type domain.
Sequence caution	The sequence AAO90899.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA54873.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Ligand	2Fe-2S 3Fe-4S 4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 3 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW succinate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 235

235

Succinate dehydrogenase iron-sulfur subunit

PRO_0000158687

Regions

Domain

133 – 163

4Fe-4S ferredoxin-type

Sites

Metal binding

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

143

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

146

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

149

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

153

Iron-sulfur 3 (3Fe-4S) By similarity

Metal binding

200

Iron-sulfur 3 (3Fe-4S) By similarity

Metal binding

206

Iron-sulfur 3 (3Fe-4S) By similarity

Metal binding

210

Iron-sulfur 2 (4Fe-4S) By similarity

Binding site

158

Ubiquinone; shared with sdhD subunit By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P51053 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 5949664A63BF5B41
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FASTA

235

26,847

        10         20         30         40         50         60 
MTFSIMRFNP ETDKKPYMQD FELDVSAIQG KMLLNALEAL REKHPDIGLR RSCAEGVCGS 

        70         80         90        100        110        120 
DGMNINGKNA LACVTQLKDL PDRVVVRPLP GFPIIRDLIV DMEQFYAQYK KVKPYLLNDQ 

       130        140        150        160        170        180 
EAPQKERLQS PEERAKLDGL YECILCACCS SSCPSYWWNP DKFIGPAGLL WSYRFIADSR 

       190        200        210        220        230 
DSKEKERLDA MKDPYSVFRC RTIMDCATVC PKNLNPAKAI RKIRTEMLQE TESGE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii." Heinzen R.A., Mo Y.-Y., Robertson S.J., Mallavia L.P. Gene 155:27-34(1995) [PubMed: 7698664] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Nine Mile.
[2]	Thiele D., Willems H., Oswald W., Krauss H. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Nine Mile.
[3]	"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L33409 Genomic DNA. Translation: AAA74134.1. X77919 Genomic DNA. Translation: CAA54873.1. Different initiation. AE016828 Genomic DNA. Translation: AAO90899.1. Different initiation.
PIR	S42873.
RefSeq	NP_820385.1. NC_002971.3.
3D structure databases
ProteinModelPortal	P51053.
SMR	P51053. Positions 1-229.
ModBase	Search...
Proteomic databases
PRIDE	P51053.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1209306.
GenomeReviews	Gene locus CBU_1400 in contig AE016828_GR.
KEGG	cbu:CBU_1400.
NMPDR	fig\|227377.1.peg.1329.
PATRIC	17931557. VBICoxBur82552_1402.
TIGR	CBU_1400.
Phylogenomic databases
HOGENOM	HBG616382.
OMA	KSYLDGT.
PhylomeDB	P51053.
ProtClustDB	PRK05950.
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_1400-MONOMER.
Family and domain databases
InterPro	IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. IPR012675. Beta-grasp_ferredoxin-type. IPR001041. Ferredoxin. IPR012285. Fum_reductase_C. IPR009051. Helical_ferredxn. IPR004489. Succ_DH/fum_Rdtase_Fe-S. [Graphical view]
Gene3D	G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit. G3DSA:1.10.1060.10. Fum_reductase_C. 1 hit.
KO	K00240.
SUPFAM	SSF54292. Ferredoxin. 1 hit. SSF46548. Helical_ferredxn. 1 hit.
TIGRFAMs	TIGR00384. DhsB. 1 hit.
PROSITE	PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHSB_COXBU

Accession

Primary (citable) accession number: P51053

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents