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P51053

- SDHB_COXBU

UniProt

P51053 - SDHB_COXBU

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Protein

Succinate dehydrogenase iron-sulfur subunit

Gene

sdhB

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi58 – 581Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi73 – 731Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi143 – 1431Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi146 – 1461Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi149 – 1491Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi153 – 1531Iron-sulfur 3 (3Fe-4S)By similarity
Binding sitei158 – 1581Ubiquinone; shared with SdhD subunitBy similarity
Metal bindingi200 – 2001Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi206 – 2061Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi210 – 2101Iron-sulfur 2 (4Fe-4S)By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1388-MONOMER.
UniPathwayiUPA00223; UER01005.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase iron-sulfur subunit (EC:1.3.5.1)
Gene namesi
Name:sdhB
Ordered Locus Names:CBU_1400
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Succinate dehydrogenase iron-sulfur subunitPRO_0000158687Add
BLAST

Proteomic databases

PRIDEiP51053.

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, cytochrome b-556 and a hydrophobic protein.

Protein-protein interaction databases

STRINGi227377.CBU_1400.

Structurei

3D structure databases

ProteinModelPortaliP51053.
SMRiP51053. Positions 1-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 163314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0479.
HOGENOMiHOG000160590.
KOiK00240.
OMAiQYEKIRP.
OrthoDBiEOG6CK7MG.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51053-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTFSIMRFNP ETDKKPYMQD FELDVSAIQG KMLLNALEAL REKHPDIGLR
60 70 80 90 100
RSCAEGVCGS DGMNINGKNA LACVTQLKDL PDRVVVRPLP GFPIIRDLIV
110 120 130 140 150
DMEQFYAQYK KVKPYLLNDQ EAPQKERLQS PEERAKLDGL YECILCACCS
160 170 180 190 200
SSCPSYWWNP DKFIGPAGLL WSYRFIADSR DSKEKERLDA MKDPYSVFRC
210 220 230
RTIMDCATVC PKNLNPAKAI RKIRTEMLQE TESGE
Length:235
Mass (Da):26,847
Last modified:October 1, 1996 - v1
Checksum:i5949664A63BF5B41
GO

Sequence cautioni

The sequence AAO90899.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA54873.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33409 Genomic DNA. Translation: AAA74134.1.
X77919 Genomic DNA. Translation: CAA54873.1. Different initiation.
AE016828 Genomic DNA. Translation: AAO90899.1. Different initiation.
PIRiS42873.
RefSeqiNP_820385.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90899; AAO90899; CBU_1400.
GeneIDi1209306.
KEGGicbu:CBU_1400.
PATRICi17931557. VBICoxBur82552_1402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33409 Genomic DNA. Translation: AAA74134.1 .
X77919 Genomic DNA. Translation: CAA54873.1 . Different initiation.
AE016828 Genomic DNA. Translation: AAO90899.1 . Different initiation.
PIRi S42873.
RefSeqi NP_820385.1. NC_002971.3.

3D structure databases

ProteinModelPortali P51053.
SMRi P51053. Positions 1-229.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1400.

Proteomic databases

PRIDEi P51053.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO90899 ; AAO90899 ; CBU_1400 .
GeneIDi 1209306.
KEGGi cbu:CBU_1400.
PATRICi 17931557. VBICoxBur82552_1402.

Phylogenomic databases

eggNOGi COG0479.
HOGENOMi HOG000160590.
KOi K00240.
OMAi QYEKIRP.
OrthoDBi EOG6CK7MG.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01005 .
BioCyci CBUR227377:GJ7S-1388-MONOMER.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii."
    Heinzen R.A., Mo Y.-Y., Robertson S.J., Mallavia L.P.
    Gene 155:27-34(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Nine Mile.
  2. Thiele D., Willems H., Oswald W., Krauss H.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Nine Mile.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiSDHB_COXBU
AccessioniPrimary (citable) accession number: P51053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3