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Protein

Melatonin receptor type 1B

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-GGA-373076. Class A/1 (Rhodopsin-like receptors).
R-GGA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin receptor type 1B
Short name:
Mel-1B-R
Short name:
Mel1b receptor
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 2›2CytoplasmicSequence analysis
Transmembranei3 – 2321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini24 – 4118ExtracellularSequence analysisAdd
BLAST
Transmembranei42 – 6221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini63 – 8119CytoplasmicSequence analysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini103 – 12624ExtracellularSequence analysisAdd
BLAST
Transmembranei127 – 14721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini148 – 17932CytoplasmicSequence analysisAdd
BLAST
Transmembranei180 – 20021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini201 – 21313ExtracellularSequence analysisAdd
BLAST
Transmembranei214 – 23421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini235 – 28955CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2095154.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 289›289Melatonin receptor type 1BPRO_0000069873Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 116PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP51050.

Expressioni

Tissue specificityi

Brain and kidney, with trace levels in lungs.

Gene expression databases

ExpressionAtlasiP51050. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027791.

Chemistry

BindingDBiP51050.

Structurei

3D structure databases

ProteinModelPortaliP51050.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHFY. Eukaryota.
ENOG4111ZZV. LUCA.
HOGENOMiHOG000037953.
HOVERGENiHBG052528.
InParanoidiP51050.
KOiK04286.
OrthoDBiEOG7MD4Q5.
PhylomeDBiP51050.
TreeFamiTF331693.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR027459. Mel_rcpt_1B.
IPR000025. Melatonin_rcpt.
[Graphical view]
PANTHERiPTHR24242:SF262. PTHR24242:SF262. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P51050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GNAFVVSLAL ADLVVALYPY PLVLLAIFHN GWTLGEMHCK VSGFVMGLSV
60 70 80 90 100
IGSIFNITAI AINRYCYICH SFAYDKVYSC WNTMLYVSLI WVLTVIATVP
110 120 130 140 150
NFFVGSLKYD PRIYSCTFVQ TASSYYTIAV VVIHFIVPIT VVSFCYLRIW
160 170 180 190 200
VLVLQVRRRV KSETKPRLKP SDFRNFLTMF VVFVIFAFCW APLNFIGLAV
210 220 230 240 250
AINPSEMAPK VPEWLFIISY FMAYFNSCLN AIIYGLLNQN FRNEYKRILM
260 270 280
SLWMPRLFFQ DTSKGGTDGQ KSKPSPALNN NDQMKTDTL
Length:289
Mass (Da):33,001
Last modified:October 1, 1996 - v1
Checksum:i08F0B3EC1BFB3FF1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30609 mRNA. Translation: AAA85098.1.
PIRiS72554.
RefSeqiNP_001280032.1. NM_001293103.1.
UniGeneiGga.767.

Genome annotation databases

GeneIDi396338.
KEGGigga:396338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30609 mRNA. Translation: AAA85098.1.
PIRiS72554.
RefSeqiNP_001280032.1. NM_001293103.1.
UniGeneiGga.767.

3D structure databases

ProteinModelPortaliP51050.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027791.

Chemistry

BindingDBiP51050.
ChEMBLiCHEMBL2095154.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP51050.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396338.
KEGGigga:396338.

Organism-specific databases

CTDi4544.

Phylogenomic databases

eggNOGiENOG410IHFY. Eukaryota.
ENOG4111ZZV. LUCA.
HOGENOMiHOG000037953.
HOVERGENiHBG052528.
InParanoidiP51050.
KOiK04286.
OrthoDBiEOG7MD4Q5.
PhylomeDBiP51050.
TreeFamiTF331693.

Enzyme and pathway databases

ReactomeiR-GGA-373076. Class A/1 (Rhodopsin-like receptors).
R-GGA-418594. G alpha (i) signalling events.

Gene expression databases

ExpressionAtlasiP51050. baseline.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR027459. Mel_rcpt_1B.
IPR000025. Melatonin_rcpt.
[Graphical view]
PANTHERiPTHR24242:SF262. PTHR24242:SF262. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular and functional characterization of a partial cDNA encoding a novel chicken brain melatonin receptor."
    Liu F., Yuan H., Sugamori K.S., Hamadanizadeh A., Lee F.J.S., Pang S.F., Brown G.M., Pristupa Z.B., Niznik H.B.
    FEBS Lett. 374:273-278(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiMTR1B_CHICK
AccessioniPrimary (citable) accession number: P51050
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 9, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.