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P51045 (CISY_ACIFR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.16
Gene names
Name:gltA
OrganismAcidithiobacillus ferrooxidans (Thiobacillus ferrooxidans)
Taxonomic identifier920 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAcidithiobacillalesAcidithiobacillaceaeAcidithiobacillus

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 386386Citrate synthase
PRO_0000169975

Sites

Active site2661 By similarity
Active site3221 By similarity

Sequences

Sequence LengthMass (Da)Tools
P51045 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 5BD23A43016A6B89

FASTA38642,689
        10         20         30         40         50         60 
MAEPNFAPGL EGVAATQSSI SNIDGAAGLL SYRGFAIADL AAHSSFEEVA LLLLDGVLPG 

        70         80         90        100        110        120 
AADLERFDHG LRAHRQVKYN VREIMKFMPV TGHPMDMLHC AVASLGMFYP QQELSDAERG 

       130        140        150        160        170        180 
NTLHLDAMAM RIIARMPTIV AMWEQMRFGN DPISPRPDLS HAANFLYMLS GREPDPAHTK 

       190        200        210        220        230        240 
ILDSCLILHA EHTINASTFS VLVTGSTLTN PYHVIGGAIG TLAGPLHGGA NQKVVEMLEE 

       250        260        270        280        290        300 
ISSVQQVGAY LDRKMANKEK IWGFGHRIYK TRDPRAVILK GMMEDMASHG NLRHSSLFEI 

       310        320        330        340        350        360 
AIEVERQATE RLGAQGIHAN VDFYSGVLYH EMGIKADLFT PIFAMARSAG WLAHWREQLA 

       370        380 
DNRIFRPTQV YTGEQDRRYV PVAQRT 

« Hide

References

[1]"The gene for gamma-glutamylcysteine synthetase from Thiobacillus ferrooxidans has low homology to its Escherichia coli equivalent and is linked to the gene for citrate synthase."
Powles R.E., Deane S.M., Rawlings D.E.
Microbiology 142:2543-2548(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 33020 / 11Fe.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U81808 Genomic DNA. Translation: AAB41629.1.
PIRD59237.

3D structure databases

ProteinModelPortalP51045.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR011278. 2-MeCitrate/Citrate_synth_I.
IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01800. cit_synth_II. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_ACIFR
AccessionPrimary (citable) accession number: P51045
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways