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P51044

- CISY_ASPNG

UniProt

P51044 - CISY_ASPNG

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Protein

Citrate synthase, mitochondrial

Gene

cit-1

Organism
Aspergillus niger
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei310 – 3101PROSITE-ProRule annotation
Active sitei356 – 3561PROSITE-ProRule annotation
Active sitei411 – 4111PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.16)
Gene namesi
Name:cit-1
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 475Citrate synthase, mitochondrialPRO_0000005475
Transit peptidei1 – ?MitochondrionBy similarity

Proteomic databases

PRIDEiP51044.

Structurei

3D structure databases

ProteinModelPortaliP51044.
SMRiP51044. Positions 39-464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51044-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASTLRLGTS ALRSSSIAAK PVVQSAAFNG LRCYSTGKAK SLKETFAEKL
60 70 80 90 100
PAELEKVKKL RKEHGSKVIG EVTLDQAYGG ARGVKCLVWE GSVLDSEEGI
110 120 130 140 150
RFRGRTIPEC QELLPKAPGG QEPLPEGLFW LLLTGEIPTE QQVRDLSAEW
160 170 180 190 200
AARSDLPKFI EELIDRCPST LHPMSQFSLA VTALEHESAF AKAYAKGINK
210 220 230 240 250
KDYWNYTFED SMDLIAKLPT IAAKIYRNVF KDGKVAPIQK DKDYSYNLAN
260 270 280 290 300
QLGYGDNNDF VELMRLYLTI HSDHEGGNVS AHTTHLVGSA LSSPMLSLAA
310 320 330 340 350
GLNGLAGPLH GLANQEVLNW LTKMKAAIGN DLSDEAIKNY LWSTLNAGQV
360 370 380 390 400
VPGYGHAVLR KTDPRYVSQR EFALRKLPDD PMFKLVSQVY KIAPGVLTEH
410 420 430 440 450
GKTKNPYPNV DAHSGVLLQY YGLTEANYYT VLFGVSRALG VLPQLIIDRA
460 470
LGAPIERPKS YSTELSPSLL VLSCK
Length:475
Mass (Da):52,154
Last modified:October 1, 1996 - v1
Checksum:iF93525B3F31FCB3F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D63376 mRNA. Translation: BAA09691.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D63376 mRNA. Translation: BAA09691.1 .

3D structure databases

ProteinModelPortali P51044.
SMRi P51044. Positions 39-464.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P51044.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0372.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of cDNA encoding Aspergillus niger citrate synthase in Esherichia coli."
    Oshida Y., Miyake K., Kanayama S., Kirimura K., Usami S.
    Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: WU-2223L.

Entry informationi

Entry nameiCISY_ASPNG
AccessioniPrimary (citable) accession number: P51044
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3