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P51043 (CISY_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.1
Gene names
Name:gltA
Ordered Locus Names:RT0832
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Citrate synthase
PRO_0000169971

Sites

Active site3111 By similarity
Active site3701 By similarity

Sequences

Sequence LengthMass (Da)Tools
P51043 [UniParc].

Last modified November 9, 2004. Version 3.
Checksum: 4CAEE2F837D1DF02

FASTA43649,289
        10         20         30         40         50         60 
MTNGNNNNLE FAELKIRGKM FKLPILKASI GKDVIDISRV SAEADCFTYD PGFMSTASCQ 

        70         80         90        100        110        120 
STITYIDGDK GILWHRGYDI KDLAEKSDFL EVAYLMIYGE LPSSEQYHNF TTKIAHHALV 

       130        140        150        160        170        180 
NERLHYLFQT FCSSSHPMAI MLAAVGSLSA FYPDLLNFNE TDYELTAIRM IAKIPTIAAM 

       190        200        210        220        230        240 
SYKYSIGQPF IYPDNSLDFT ENFLHMMFAT PCTKYKVNPI IKNALNKIFI LHADHEQNAS 

       250        260        270        280        290        300 
TSTVRIAGSS GANPFACIST GIASLWGPAH GGANEAVINM LKEIGSSENI PKYVAKAKDK 

       310        320        330        340        350        360 
NDPFRLMGFG HRVYKSYDPR AAVLKETCKE VLNELGQLEN NPLLQIAIEL EALALKDEYF 

       370        380        390        400        410        420 
IERKLYPNVD FYSGIIYKAM GIPSQMFTVL FAIARTVGWM AQWKEMHEDP EQKISRPRQL 

       430 
YTGYVHREYK CIVERK 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.
[2]"Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae."
Roux V., Rydkina E., Eremeeva M., Raoult D.
Int. J. Syst. Bacteriol. 47:252-261(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-418.
Strain: ATCC VR-144 / Wilmington.
[3]Balayeva N., Eremeeva M., Tissot-Dupont H., Zakharov I., Raoult D.
Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 271-389.
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU04286.1.
U59714 Genomic DNA. Translation: AAB02973.1.
U20245 Genomic DNA. Translation: AAA85709.1.
RefSeqYP_067768.1. NC_006142.1.

3D structure databases

ProteinModelPortalP51043.
SMRP51043. Positions 12-435.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0832.

Proteomic databases

PRIDEP51043.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU04286; AAU04286; RT0832.
GeneID2959016.
KEGGrty:RT0832.
PATRIC17910916. VBIRicTyp34752_0849.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0372.
HOGENOMHOG000021224.
KOK01647.
OMAVERIPEF.
OrthoDBEOG6P8TP4.
ProtClustDBPRK05614.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-872-MONOMER.
UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-II.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01798. cit_synth_I. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_RICTY
AccessionPrimary (citable) accession number: P51043
Secondary accession number(s): Q68VS0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 9, 2004
Last modified: November 13, 2013
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways