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P51043

- CISY_RICTY

UniProt

P51043 - CISY_RICTY

Protein

Citrate synthase

Gene

gltA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 3 (09 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei311 – 3111PROSITE-ProRule annotation
    Active sitei370 – 3701PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-872-MONOMER.
    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase (EC:2.3.3.16)
    Gene namesi
    Name:gltA
    Ordered Locus Names:RT0832
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Citrate synthasePRO_0000169971Add
    BLAST

    Proteomic databases

    PRIDEiP51043.

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0832.

    Structurei

    3D structure databases

    ProteinModelPortaliP51043.
    SMRiP51043. Positions 12-435.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0372.
    HOGENOMiHOG000021224.
    KOiK01647.
    OMAiKFPTIVA.
    OrthoDBiEOG6P8TP4.

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51043-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNGNNNNLE FAELKIRGKM FKLPILKASI GKDVIDISRV SAEADCFTYD    50
    PGFMSTASCQ STITYIDGDK GILWHRGYDI KDLAEKSDFL EVAYLMIYGE 100
    LPSSEQYHNF TTKIAHHALV NERLHYLFQT FCSSSHPMAI MLAAVGSLSA 150
    FYPDLLNFNE TDYELTAIRM IAKIPTIAAM SYKYSIGQPF IYPDNSLDFT 200
    ENFLHMMFAT PCTKYKVNPI IKNALNKIFI LHADHEQNAS TSTVRIAGSS 250
    GANPFACIST GIASLWGPAH GGANEAVINM LKEIGSSENI PKYVAKAKDK 300
    NDPFRLMGFG HRVYKSYDPR AAVLKETCKE VLNELGQLEN NPLLQIAIEL 350
    EALALKDEYF IERKLYPNVD FYSGIIYKAM GIPSQMFTVL FAIARTVGWM 400
    AQWKEMHEDP EQKISRPRQL YTGYVHREYK CIVERK 436
    Length:436
    Mass (Da):49,289
    Last modified:November 9, 2004 - v3
    Checksum:i4CAEE2F837D1DF02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04286.1.
    U59714 Genomic DNA. Translation: AAB02973.1.
    U20245 Genomic DNA. Translation: AAA85709.1.
    RefSeqiWP_011191260.1. NC_006142.1.
    YP_067768.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU04286; AAU04286; RT0832.
    GeneIDi2959016.
    KEGGirty:RT0832.
    PATRICi17910916. VBIRicTyp34752_0849.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04286.1 .
    U59714 Genomic DNA. Translation: AAB02973.1 .
    U20245 Genomic DNA. Translation: AAA85709.1 .
    RefSeqi WP_011191260.1. NC_006142.1.
    YP_067768.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali P51043.
    SMRi P51043. Positions 12-435.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0832.

    Proteomic databases

    PRIDEi P51043.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU04286 ; AAU04286 ; RT0832 .
    GeneIDi 2959016.
    KEGGi rty:RT0832.
    PATRICi 17910916. VBIRicTyp34752_0849.

    Phylogenomic databases

    eggNOGi COG0372.
    HOGENOMi HOG000021224.
    KOi K01647.
    OMAi KFPTIVA.
    OrthoDBi EOG6P8TP4.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .
    BioCyci RTYP257363:GJEQ-872-MONOMER.

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.
    2. "Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae."
      Roux V., Rydkina E., Eremeeva M., Raoult D.
      Int. J. Syst. Bacteriol. 47:252-261(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-418.
      Strain: ATCC VR-144 / Wilmington.
    3. Balayeva N., Eremeeva M., Tissot-Dupont H., Zakharov I., Raoult D.
      Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 271-389.
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiCISY_RICTY
    AccessioniPrimary (citable) accession number: P51043
    Secondary accession number(s): Q68VS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 9, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3