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P51043

- CISY_RICTY

UniProt

P51043 - CISY_RICTY

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Protein
Citrate synthase
Gene
gltA, RT0832
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei311 – 3111 By similarity
Active sitei370 – 3701 By similarity

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-872-MONOMER.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
Ordered Locus Names:RT0832
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Citrate synthase
PRO_0000169971Add
BLAST

Proteomic databases

PRIDEiP51043.

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0832.

Structurei

3D structure databases

ProteinModelPortaliP51043.
SMRiP51043. Positions 12-435.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000021224.
KOiK01647.
OMAiKFPTIVA.
OrthoDBiEOG6P8TP4.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51043-1 [UniParc]FASTAAdd to Basket

« Hide

MTNGNNNNLE FAELKIRGKM FKLPILKASI GKDVIDISRV SAEADCFTYD    50
PGFMSTASCQ STITYIDGDK GILWHRGYDI KDLAEKSDFL EVAYLMIYGE 100
LPSSEQYHNF TTKIAHHALV NERLHYLFQT FCSSSHPMAI MLAAVGSLSA 150
FYPDLLNFNE TDYELTAIRM IAKIPTIAAM SYKYSIGQPF IYPDNSLDFT 200
ENFLHMMFAT PCTKYKVNPI IKNALNKIFI LHADHEQNAS TSTVRIAGSS 250
GANPFACIST GIASLWGPAH GGANEAVINM LKEIGSSENI PKYVAKAKDK 300
NDPFRLMGFG HRVYKSYDPR AAVLKETCKE VLNELGQLEN NPLLQIAIEL 350
EALALKDEYF IERKLYPNVD FYSGIIYKAM GIPSQMFTVL FAIARTVGWM 400
AQWKEMHEDP EQKISRPRQL YTGYVHREYK CIVERK 436
Length:436
Mass (Da):49,289
Last modified:November 9, 2004 - v3
Checksum:i4CAEE2F837D1DF02
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04286.1.
U59714 Genomic DNA. Translation: AAB02973.1.
U20245 Genomic DNA. Translation: AAA85709.1.
RefSeqiWP_011191260.1. NC_006142.1.
YP_067768.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04286; AAU04286; RT0832.
GeneIDi2959016.
KEGGirty:RT0832.
PATRICi17910916. VBIRicTyp34752_0849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04286.1 .
U59714 Genomic DNA. Translation: AAB02973.1 .
U20245 Genomic DNA. Translation: AAA85709.1 .
RefSeqi WP_011191260.1. NC_006142.1.
YP_067768.1. NC_006142.1.

3D structure databases

ProteinModelPortali P51043.
SMRi P51043. Positions 12-435.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0832.

Proteomic databases

PRIDEi P51043.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU04286 ; AAU04286 ; RT0832 .
GeneIDi 2959016.
KEGGi rty:RT0832.
PATRICi 17910916. VBIRicTyp34752_0849.

Phylogenomic databases

eggNOGi COG0372.
HOGENOMi HOG000021224.
KOi K01647.
OMAi KFPTIVA.
OrthoDBi EOG6P8TP4.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BioCyci RTYP257363:GJEQ-872-MONOMER.

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.
  2. "Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae."
    Roux V., Rydkina E., Eremeeva M., Raoult D.
    Int. J. Syst. Bacteriol. 47:252-261(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-418.
    Strain: ATCC VR-144 / Wilmington.
  3. Balayeva N., Eremeeva M., Tissot-Dupont H., Zakharov I., Raoult D.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 271-389.
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiCISY_RICTY
AccessioniPrimary (citable) accession number: P51043
Secondary accession number(s): Q68VS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 9, 2004
Last modified: September 3, 2014
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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