ID CISY_RICCN Reviewed; 435 AA. AC P51042; Q59737; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 11-JUL-2001, sequence version 3. DT 27-MAR-2024, entry version 130. DE RecName: Full=Citrate synthase; DE EC=2.3.3.16; GN Name=gltA; OrderedLocusNames=RC1308; OS Rickettsia conorii (strain ATCC VR-613 / Malish 7). OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales; OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group. OX NCBI_TaxID=272944; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC VR-613 / Malish 7; RX PubMed=11557893; DOI=10.1126/science.1061471; RA Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., RA Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.; RT "Mechanisms of evolution in Rickettsia conorii and R. prowazekii."; RL Science 293:2093-2098(2001). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-418. RC STRAIN=ATCC VR-613 / Malish 7; RX PubMed=9103608; DOI=10.1099/00207713-47-2-252; RA Roux V., Rydkina E., Eremeeva M., Raoult D.; RT "Citrate synthase gene comparison, a new tool for phylogenetic analysis, RT and its application for the rickettsiae."; RL Int. J. Syst. Bacteriol. 47:252-261(1997). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 269-387. RC STRAIN=ATCC VR-613 / Malish 7; RA Balayeva N., Eremeeva M., Tissot-Dupont H., Zakharov I., Raoult D.; RL Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+); CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287, CC ChEBI:CHEBI:57288; EC=2.3.3.16; Evidence={ECO:0000255|PROSITE- CC ProRule:PRU10117}; CC -!- ACTIVITY REGULATION: Allosterically inhibited by NADH. {ECO:0000250}. CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate CC from oxaloacetate: step 1/2. CC -!- SUBUNIT: Homohexamer. {ECO:0000250}. CC -!- MISCELLANEOUS: Citrate synthase is found in nearly all cells capable of CC oxidative metabolism. CC -!- SIMILARITY: Belongs to the citrate synthase family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE006914; AAL03846.1; -; Genomic_DNA. DR EMBL; U59730; AAB02958.1; -; Genomic_DNA. DR EMBL; U20243; AAA85707.1; -; Genomic_DNA. DR PIR; D97863; D97863. DR RefSeq; WP_010977866.1; NC_003103.1. DR AlphaFoldDB; P51042; -. DR SMR; P51042; -. DR GeneID; 928457; -. DR KEGG; rco:RC1308; -. DR PATRIC; fig|272944.4.peg.1501; -. DR HOGENOM; CLU_025068_0_0_5; -. DR UniPathway; UPA00223; UER00717. DR Proteomes; UP000000816; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro. DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. DR CDD; cd06114; EcCS_like; 1. DR Gene3D; 2.20.28.60; -; 1. DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1. DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1. DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub. DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub. DR InterPro; IPR002020; Citrate_synthase. DR InterPro; IPR019810; Citrate_synthase_AS. DR InterPro; IPR024176; Citrate_synthase_bac-typ. DR InterPro; IPR036969; Citrate_synthase_sf. DR InterPro; IPR010953; Citrate_synthase_typ-I. DR NCBIfam; TIGR01798; cit_synth_I; 1. DR PANTHER; PTHR42871; CITRATE SYNTHASE; 1. DR PANTHER; PTHR42871:SF1; CITRATE SYNTHASE; 1. DR Pfam; PF00285; Citrate_synt; 1. DR PIRSF; PIRSF001369; Citrate_synth; 1. DR PRINTS; PR00143; CITRTSNTHASE. DR SUPFAM; SSF48256; Citrate synthase; 1. DR PROSITE; PS00480; CITRATE_SYNTHASE; 1. PE 3: Inferred from homology; KW Allosteric enzyme; Transferase; Tricarboxylic acid cycle. FT CHAIN 1..435 FT /note="Citrate synthase" FT /id="PRO_0000169961" FT ACT_SITE 311 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10117" FT ACT_SITE 370 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10117" FT CONFLICT 281 FT /note="I -> L (in Ref. 3; AAA85707)" FT /evidence="ECO:0000305" SQ SEQUENCE 435 AA; 49210 MW; 4CBFF074A1807853 CRC64; MTNENNNDSE FAELKIRGKI FKLPILKASI GEDVIDISRV SAEADCFTYD PGFMSTASCQ STITYIDGDK GILRHRGYDI KDLAEKSDFL EVAYLLIYGE LPSGEQYNNF TKQVAHHSLV NERLHYLFQT FCSSSHPMAI MLAAVGSLSA FYPDLLNFKE ADYELTAIRM IAKIPTIAAM SYKYSIGQPF IYPDNSLDFT ENFLHMMFAT PCTKYTVNPI IKNALNKIFI LHADHEQNAS TSTVRIAGSS GANPFACIST GIASLWGPAH GGANEAVINM IKEIGSSEYI PKYIAKAKDK NDPFRLMGFG HRVYKNYDPR AAVLKETCKE VLKELGQLDN NPFLQIAIEL EAIALKDEYF IERKLYPNVD FYSGIIYKAM GIPSQMFTVL FAIARTVGWM AQWKEMHEDP EQKISRPRQL YTGYVHREYK GIRER //