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Protein

Citrate synthase

Gene

gltA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Enzyme regulationi

Allosterically inhibited by NADH.By similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Citrate synthase (gltA)
  2. Aconitate hydratase A (acnA)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei311PROSITE-ProRule annotation1
Active sitei370PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Transferase
Biological processTricarboxylic acid cycle

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-2103-MONOMER.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
Ordered Locus Names:RC1308
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001699611 – 435Citrate synthaseAdd BLAST435

Interactioni

Subunit structurei

Homohexamer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP51042.
SMRiP51042.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

HOGENOMiHOG000021224.
KOiK01647.
OMAiTVGWCAQ.
OrthoDBiPOG091H00T5.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 2 hits.
InterProiView protein in InterPro
IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR036969. Citrate_synthase_sf.
IPR010953. Citrate_synthase_typ-I.
PfamiView protein in Pfam
PF00285. Citrate_synt. 1 hit.
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiView protein in PROSITE
PS00480. CITRATE_SYNTHASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P51042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNENNNDSE FAELKIRGKI FKLPILKASI GEDVIDISRV SAEADCFTYD
60 70 80 90 100
PGFMSTASCQ STITYIDGDK GILRHRGYDI KDLAEKSDFL EVAYLLIYGE
110 120 130 140 150
LPSGEQYNNF TKQVAHHSLV NERLHYLFQT FCSSSHPMAI MLAAVGSLSA
160 170 180 190 200
FYPDLLNFKE ADYELTAIRM IAKIPTIAAM SYKYSIGQPF IYPDNSLDFT
210 220 230 240 250
ENFLHMMFAT PCTKYTVNPI IKNALNKIFI LHADHEQNAS TSTVRIAGSS
260 270 280 290 300
GANPFACIST GIASLWGPAH GGANEAVINM IKEIGSSEYI PKYIAKAKDK
310 320 330 340 350
NDPFRLMGFG HRVYKNYDPR AAVLKETCKE VLKELGQLDN NPFLQIAIEL
360 370 380 390 400
EAIALKDEYF IERKLYPNVD FYSGIIYKAM GIPSQMFTVL FAIARTVGWM
410 420 430
AQWKEMHEDP EQKISRPRQL YTGYVHREYK GIRER
Length:435
Mass (Da):49,210
Last modified:July 11, 2001 - v3
Checksum:i4CBFF074A1807853
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti281I → L in AAA85707 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03846.1.
U59730 Genomic DNA. Translation: AAB02958.1.
U20243 Genomic DNA. Translation: AAA85707.1.
PIRiD97863.
RefSeqiWP_010977866.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03846; AAL03846; RC1308.
GeneIDi928457.
KEGGirco:RC1308.
PATRICifig|272944.4.peg.1501.

Similar proteinsi

Entry informationi

Entry nameiCISY_RICCN
AccessioniPrimary (citable) accession number: P51042
Secondary accession number(s): Q59737
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 11, 2001
Last modified: February 28, 2018
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome