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P51042 (CISY_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.1
Gene names
Name:gltA
Ordered Locus Names:RC1308
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Enzyme regulation

Allosterically inhibited by NADH By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homohexamer By similarity.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
   Technical termAllosteric enzyme
Complete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Citrate synthase
PRO_0000169961

Sites

Active site3111 By similarity
Active site3701 By similarity

Experimental info

Sequence conflict2811I → L in AAA85707. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P51042 [UniParc].

Last modified July 11, 2001. Version 3.
Checksum: 4CBFF074A1807853

FASTA43549,210
        10         20         30         40         50         60 
MTNENNNDSE FAELKIRGKI FKLPILKASI GEDVIDISRV SAEADCFTYD PGFMSTASCQ 

        70         80         90        100        110        120 
STITYIDGDK GILRHRGYDI KDLAEKSDFL EVAYLLIYGE LPSGEQYNNF TKQVAHHSLV 

       130        140        150        160        170        180 
NERLHYLFQT FCSSSHPMAI MLAAVGSLSA FYPDLLNFKE ADYELTAIRM IAKIPTIAAM 

       190        200        210        220        230        240 
SYKYSIGQPF IYPDNSLDFT ENFLHMMFAT PCTKYTVNPI IKNALNKIFI LHADHEQNAS 

       250        260        270        280        290        300 
TSTVRIAGSS GANPFACIST GIASLWGPAH GGANEAVINM IKEIGSSEYI PKYIAKAKDK 

       310        320        330        340        350        360 
NDPFRLMGFG HRVYKNYDPR AAVLKETCKE VLKELGQLDN NPFLQIAIEL EAIALKDEYF 

       370        380        390        400        410        420 
IERKLYPNVD FYSGIIYKAM GIPSQMFTVL FAIARTVGWM AQWKEMHEDP EQKISRPRQL 

       430 
YTGYVHREYK GIRER 

« Hide

References

« Hide 'large scale' references
[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.
[2]"Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae."
Roux V., Rydkina E., Eremeeva M., Raoult D.
Int. J. Syst. Bacteriol. 47:252-261(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-418.
Strain: ATCC VR-613 / Malish 7.
[3]Balayeva N., Eremeeva M., Tissot-Dupont H., Zakharov I., Raoult D.
Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 269-387.
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03846.1.
U59730 Genomic DNA. Translation: AAB02958.1.
U20243 Genomic DNA. Translation: AAA85707.1.
PIRD97863.
RefSeqNP_360945.1. NC_003103.1.

3D structure databases

ProteinModelPortalP51042.
SMRP51042. Positions 12-430.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC1308.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03846; AAL03846; RC1308.
GeneID928457.
KEGGrco:RC1308.
PATRIC17890145. VBIRicCon45613_1501.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0372.
HOGENOMHOG000021224.
KOK01647.
OMANKEDGVR.
OrthoDBEOG6P8TP4.
ProtClustDBPRK05614.

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-II.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01798. cit_synth_I. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_RICCN
AccessionPrimary (citable) accession number: P51042
Secondary accession number(s): Q59737
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 11, 2001
Last modified: November 13, 2013
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways