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P51042

- CISY_RICCN

UniProt

P51042 - CISY_RICCN

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Protein

Citrate synthase

Gene

gltA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Enzyme regulationi

Allosterically inhibited by NADH.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei311 – 3111PROSITE-ProRule annotation
Active sitei370 – 3701PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
Ordered Locus Names:RC1308
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Citrate synthasePRO_0000169961Add
BLAST

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi272944.RC1308.

Structurei

3D structure databases

ProteinModelPortaliP51042.
SMRiP51042. Positions 12-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000021224.
KOiK01647.
OMAiKETCDEV.
OrthoDBiEOG6P8TP4.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51042-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNENNNDSE FAELKIRGKI FKLPILKASI GEDVIDISRV SAEADCFTYD
60 70 80 90 100
PGFMSTASCQ STITYIDGDK GILRHRGYDI KDLAEKSDFL EVAYLLIYGE
110 120 130 140 150
LPSGEQYNNF TKQVAHHSLV NERLHYLFQT FCSSSHPMAI MLAAVGSLSA
160 170 180 190 200
FYPDLLNFKE ADYELTAIRM IAKIPTIAAM SYKYSIGQPF IYPDNSLDFT
210 220 230 240 250
ENFLHMMFAT PCTKYTVNPI IKNALNKIFI LHADHEQNAS TSTVRIAGSS
260 270 280 290 300
GANPFACIST GIASLWGPAH GGANEAVINM IKEIGSSEYI PKYIAKAKDK
310 320 330 340 350
NDPFRLMGFG HRVYKNYDPR AAVLKETCKE VLKELGQLDN NPFLQIAIEL
360 370 380 390 400
EAIALKDEYF IERKLYPNVD FYSGIIYKAM GIPSQMFTVL FAIARTVGWM
410 420 430
AQWKEMHEDP EQKISRPRQL YTGYVHREYK GIRER
Length:435
Mass (Da):49,210
Last modified:July 11, 2001 - v3
Checksum:i4CBFF074A1807853
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti281 – 2811I → L in AAA85707. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03846.1.
U59730 Genomic DNA. Translation: AAB02958.1.
U20243 Genomic DNA. Translation: AAA85707.1.
PIRiD97863.
RefSeqiNP_360945.1. NC_003103.1.
WP_010977866.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03846; AAL03846; RC1308.
GeneIDi928457.
KEGGirco:RC1308.
PATRICi17890145. VBIRicCon45613_1501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03846.1 .
U59730 Genomic DNA. Translation: AAB02958.1 .
U20243 Genomic DNA. Translation: AAA85707.1 .
PIRi D97863.
RefSeqi NP_360945.1. NC_003103.1.
WP_010977866.1. NC_003103.1.

3D structure databases

ProteinModelPortali P51042.
SMRi P51042. Positions 12-430.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC1308.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03846 ; AAL03846 ; RC1308 .
GeneIDi 928457.
KEGGi rco:RC1308.
PATRICi 17890145. VBIRicCon45613_1501.

Phylogenomic databases

eggNOGi COG0372.
HOGENOMi HOG000021224.
KOi K01647.
OMAi KETCDEV.
OrthoDBi EOG6P8TP4.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.
  2. "Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae."
    Roux V., Rydkina E., Eremeeva M., Raoult D.
    Int. J. Syst. Bacteriol. 47:252-261(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-418.
    Strain: ATCC VR-613 / Malish 7.
  3. Balayeva N., Eremeeva M., Tissot-Dupont H., Zakharov I., Raoult D.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 269-387.
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiCISY_RICCN
AccessioniPrimary (citable) accession number: P51042
Secondary accession number(s): Q59737
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 11, 2001
Last modified: October 29, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia conorii
    (strain Malish 7): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3