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P51040 (CISY_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.16
Gene names
Name:gltA
Ordered Locus Names:RF_1338
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Citrate synthase
PRO_0000169962

Sites

Active site3111 By similarity
Active site3701 By similarity

Sequences

Sequence LengthMass (Da)Tools
P51040 [UniParc].

Last modified July 19, 2005. Version 2.
Checksum: 361CAB47B3274378

FASTA43549,100
        10         20         30         40         50         60 
MTNENSNDSE FAELKIRGKI FKLPILKASI GEDVIDISRV SSEADCFTYD PGFMSTASCQ 

        70         80         90        100        110        120 
STITYIDGDK GILRHRGYDI KDLAEKSDFL EVAYLLIYGE LPSIEQYNNF TKQVAHHSLV 

       130        140        150        160        170        180 
NERLHYLFQT FCSSSHPMAI MLAAVGSLSA FYPDLLNFKE ADYELTAIRM IAKIPTIAAM 

       190        200        210        220        230        240 
SYKYSIGQPF IYPDNSLDFT ENFLHMMFAT PCTKYKVNPI IKNALNKIFI LHADHEQNAS 

       250        260        270        280        290        300 
TSTVRIAGSS GANPFACVST GIASLWGPAH GGANEAVINM LKEIGSSENI PKYIAKAKDK 

       310        320        330        340        350        360 
NDPFRLMGFG HRVYKNYDPR AAVLKETCKE VLKELGQLEN NPLLQIAIEL EAIALKDEYF 

       370        380        390        400        410        420 
IERKLYPNVD FYSGIIYKAM GIPSQMFTVL FAIARTVGWM AQWKEMHEDP EQKISRPRQL 

       430 
YTGYVHREYK GIGER 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.
[2]"Rickettsia felis: a new species of pathogenic rickettsia isolated from cat fleas."
Higgins J.A., Radulovic S., Schriefer M.E., Azad A.F.
J. Clin. Microbiol. 34:671-674(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 279-384.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY62189.1.
U33922 Genomic DNA. Translation: AAB71724.1.
RefSeqYP_247354.1. NC_007109.1.

3D structure databases

ProteinModelPortalP51040.
SMRP51040. Positions 12-430.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_1338.

Proteomic databases

PRIDEP51040.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY62189; AAY62189; RF_1338.
GeneID3400894.
KEGGrfe:RF_1338.
PATRIC17893602. VBIRicFel64634_1611.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0372.
HOGENOMHOG000021224.
KOK01647.
OMAKETCDEV.
OrthoDBEOG6P8TP4.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-1375-MONOMER.
UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-II.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01798. cit_synth_I. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_RICFE
AccessionPrimary (citable) accession number: P51040
Secondary accession number(s): Q4UJV0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways