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P51040

- CISY_RICFE

UniProt

P51040 - CISY_RICFE

Protein

Citrate synthase

Gene

gltA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei311 – 3111PROSITE-ProRule annotation
    Active sitei370 – 3701PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-1375-MONOMER.
    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase (EC:2.3.3.16)
    Gene namesi
    Name:gltA
    Ordered Locus Names:RF_1338
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 435435Citrate synthasePRO_0000169962Add
    BLAST

    Proteomic databases

    PRIDEiP51040.

    Interactioni

    Protein-protein interaction databases

    STRINGi315456.RF_1338.

    Structurei

    3D structure databases

    ProteinModelPortaliP51040.
    SMRiP51040. Positions 12-430.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0372.
    HOGENOMiHOG000021224.
    KOiK01647.
    OMAiKETCDEV.
    OrthoDBiEOG6P8TP4.

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51040-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNENSNDSE FAELKIRGKI FKLPILKASI GEDVIDISRV SSEADCFTYD    50
    PGFMSTASCQ STITYIDGDK GILRHRGYDI KDLAEKSDFL EVAYLLIYGE 100
    LPSIEQYNNF TKQVAHHSLV NERLHYLFQT FCSSSHPMAI MLAAVGSLSA 150
    FYPDLLNFKE ADYELTAIRM IAKIPTIAAM SYKYSIGQPF IYPDNSLDFT 200
    ENFLHMMFAT PCTKYKVNPI IKNALNKIFI LHADHEQNAS TSTVRIAGSS 250
    GANPFACVST GIASLWGPAH GGANEAVINM LKEIGSSENI PKYIAKAKDK 300
    NDPFRLMGFG HRVYKNYDPR AAVLKETCKE VLKELGQLEN NPLLQIAIEL 350
    EAIALKDEYF IERKLYPNVD FYSGIIYKAM GIPSQMFTVL FAIARTVGWM 400
    AQWKEMHEDP EQKISRPRQL YTGYVHREYK GIGER 435
    Length:435
    Mass (Da):49,100
    Last modified:July 19, 2005 - v2
    Checksum:i361CAB47B3274378
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62189.1.
    U33922 Genomic DNA. Translation: AAB71724.1.
    RefSeqiWP_011271638.1. NC_007109.1.
    YP_247354.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY62189; AAY62189; RF_1338.
    GeneIDi3400894.
    KEGGirfe:RF_1338.
    PATRICi17893602. VBIRicFel64634_1611.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62189.1 .
    U33922 Genomic DNA. Translation: AAB71724.1 .
    RefSeqi WP_011271638.1. NC_007109.1.
    YP_247354.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali P51040.
    SMRi P51040. Positions 12-430.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_1338.

    Proteomic databases

    PRIDEi P51040.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY62189 ; AAY62189 ; RF_1338 .
    GeneIDi 3400894.
    KEGGi rfe:RF_1338.
    PATRICi 17893602. VBIRicFel64634_1611.

    Phylogenomic databases

    eggNOGi COG0372.
    HOGENOMi HOG000021224.
    KOi K01647.
    OMAi KETCDEV.
    OrthoDBi EOG6P8TP4.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .
    BioCyci RFEL315456:GKEK-1375-MONOMER.

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.
    2. "Rickettsia felis: a new species of pathogenic rickettsia isolated from cat fleas."
      Higgins J.A., Radulovic S., Schriefer M.E., Azad A.F.
      J. Clin. Microbiol. 34:671-674(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 279-384.

    Entry informationi

    Entry nameiCISY_RICFE
    AccessioniPrimary (citable) accession number: P51040
    Secondary accession number(s): Q4UJV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3