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Protein

Citrate synthase, chromosomal

Gene

ccsA

Organism
Rhizobium tropici
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei306 – 3061PROSITE-ProRule annotation
Active sitei364 – 3641PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, chromosomal (EC:2.3.3.16)
Gene namesi
Name:ccsA
OrganismiRhizobium tropici
Taxonomic identifieri398 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Citrate synthase, chromosomalPRO_0000169954Add
BLAST

Proteomic databases

PRIDEiP51037.

Structurei

3D structure databases

ProteinModelPortaliP51037.
SMRiP51037. Positions 5-429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQSAKLTW GEKTVDLPVK TGTIGPSVID IGALYKNTST FTYDPGFTST
60 70 80 90 100
ASCESSITFI DGDEGVLLHR GYPIEQLAEH GDFLEVCYLL LYGELPTAAQ
110 120 130 140 150
KKDFDYRVVH HTMVHEQMSR FFTGFRRDAH PMAVMCGCVG ALSAFYHDST
160 170 180 190 200
DITDPHQRMV ASLRMIAKMP TLAAMAYKYH IGQPFVYPKN DLDYASNFLR
210 220 230 240 250
MCFAVPCEEY VVNPVLARAM DRIFILHADH EQNASTSTVR LAGSSGANPF
260 270 280 290 300
ACIAAGIACL WGPAHGGANE AALNMLTEIG TVDRIPEYIA RAKDKNDPFR
310 320 330 340 350
LMGFGHRVYK NYDPRAKIMQ KTAHEVLGEL GIKDDPLLDI AIELERIALT
360 370 380 390 400
DDYFIEKKLY PNVDFYSGIT LKALGFPTTM FTVLFALART VGWIAQWNEM
410 420
IEDPDQRIGR PRHVYTGAPL REYVPVSKR
Length:429
Mass (Da):47,976
Last modified:July 14, 1998 - v2
Checksum:iEBED70CBFD6948EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41815 Genomic DNA. Translation: AAB97876.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41815 Genomic DNA. Translation: AAB97876.1.

3D structure databases

ProteinModelPortaliP51037.
SMRiP51037. Positions 5-429.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP51037.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rhizobium tropici chromosomal citrate synthase gene."
    Hernandez-Lucas I., Pardo M.A., Segovia L., Miranda J., Martinez-Romero E.
    Appl. Environ. Microbiol. 61:3992-3997(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CFN 299.
  2. Rios J.M.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiCISY1_RHITR
AccessioniPrimary (citable) accession number: P51037
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 30, 1996
Last sequence update: July 14, 1998
Last modified: September 30, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.