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P51034

- CISY_BARQU

UniProt

P51034 - CISY_BARQU

Protein

Citrate synthase

Gene

gltA

Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 3 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei306 – 3061PROSITE-ProRule annotation
    Active sitei364 – 3641PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciBQUI283165:GHZA-684-MONOMER.
    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase (EC:2.3.3.16)
    Gene namesi
    Name:gltA
    Ordered Locus Names:BQ06850
    OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
    Taxonomic identifieri283165 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000000597: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 438438Citrate synthasePRO_0000169935Add
    BLAST

    Proteomic databases

    PRIDEiP51034.

    Interactioni

    Protein-protein interaction databases

    STRINGi283165.BQ06850.

    Structurei

    3D structure databases

    ProteinModelPortaliP51034.
    SMRiP51034. Positions 2-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0372.
    HOGENOMiHOG000021224.
    KOiK01647.
    OMAiKETCDEV.
    OrthoDBiEOG6P8TP4.

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51034-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSENKAHITV NNKKIELSVR KGTLGPGVIE IASLYKETDT FTYDPGFTST    50
    ASCESKITYI DGDKGILLYC GYPIDQLAEK GDFLESCYLL LYGELPTKQE 100
    KIDFDRCIMQ HMMVHEQFTR FFHGFRRDSH PMAVMVACLG AMSAFYHDSI 150
    DIKDAQQRMI AAIRLISKVP TLAAMAYKYS IGQAFVYPRN DLSYAANFLH 200
    MCFSVPCEEY KINPVLSRAM DRIFTLHADH EQNASTSTVR LVGSSGANPF 250
    ACIAAGVACL WGPAHGGANE ACLKMLQKIG SVERIPEFIA RAKDKNDPFR 300
    LMGFGHRVYK NYDPRAKIMQ QTCHEVLKEL NIQDDPLLDI AIALENTALN 350
    DEYFIEKKLY PNVDFYSGIT LKALGFPTEM FTVLFALARS IGWVAQWKEM 400
    IEDPAQKIGR PRQLYTGYAA REYVSIDKRI SKNKMTTQ 438
    Length:438
    Mass (Da):49,464
    Last modified:August 16, 2004 - v3
    Checksum:i98ED2C4A41ACD5E4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti117 – 1171Q → R in CAA93836. (PubMed:8863415)Curated
    Sequence conflicti224 – 2241F → C in CAA93836. (PubMed:8863415)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897700 Genomic DNA. Translation: CAF26174.1.
    Z70014 Genomic DNA. Translation: CAA93836.1.
    U28073 Genomic DNA. Translation: AAA74978.1.
    RefSeqiWP_011179429.1. NC_005955.1.
    YP_032322.1. NC_005955.1.

    Genome annotation databases

    EnsemblBacteriaiCAF26174; CAF26174; BQ06850.
    GeneIDi2867054.
    KEGGibqu:BQ06850.
    PATRICi31952667. VBIBarQui58630_0759.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897700 Genomic DNA. Translation: CAF26174.1 .
    Z70014 Genomic DNA. Translation: CAA93836.1 .
    U28073 Genomic DNA. Translation: AAA74978.1 .
    RefSeqi WP_011179429.1. NC_005955.1.
    YP_032322.1. NC_005955.1.

    3D structure databases

    ProteinModelPortali P51034.
    SMRi P51034. Positions 2-429.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 283165.BQ06850.

    Proteomic databases

    PRIDEi P51034.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF26174 ; CAF26174 ; BQ06850 .
    GeneIDi 2867054.
    KEGGi bqu:BQ06850.
    PATRICi 31952667. VBIBarQui58630_0759.

    Phylogenomic databases

    eggNOGi COG0372.
    HOGENOMi HOG000021224.
    KOi K01647.
    OMAi KETCDEV.
    OrthoDBi EOG6P8TP4.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .
    BioCyci BQUI283165:GHZA-684-MONOMER.

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Toulouse.
    2. "Comparison of partial citrate synthase gene (gltA) sequences for phylogenetic analysis of Bartonella species."
      Birtles R.J., Raoult D.
      Int. J. Syst. Bacteriol. 46:891-897(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-379.
      Strain: ATCC VR-358 / Fuller / CIP 107027.
    3. "Bartonella species characterization: citrate synthase (gltA) PCR product sequence analysis."
      Jones D.C., Regnery R., Bowen M.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 268-379.
      Strain: ATCC VR-358 / Fuller / CIP 107027.

    Entry informationi

    Entry nameiCISY_BARQU
    AccessioniPrimary (citable) accession number: P51034
    Secondary accession number(s): Q6FZN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3