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P51034 (CISY_BARQU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.16
Gene names
Name:gltA
Ordered Locus Names:BQ06850
OrganismBartonella quintana (strain Toulouse) (Rochalimaea quintana) [Complete proteome] [HAMAP]
Taxonomic identifier283165 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438Citrate synthase
PRO_0000169935

Sites

Active site3061 By similarity
Active site3641 By similarity

Experimental info

Sequence conflict1171Q → R in CAA93836. Ref.2
Sequence conflict2241F → C in CAA93836. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P51034 [UniParc].

Last modified August 16, 2004. Version 3.
Checksum: 98ED2C4A41ACD5E4

FASTA43849,464
        10         20         30         40         50         60 
MSENKAHITV NNKKIELSVR KGTLGPGVIE IASLYKETDT FTYDPGFTST ASCESKITYI 

        70         80         90        100        110        120 
DGDKGILLYC GYPIDQLAEK GDFLESCYLL LYGELPTKQE KIDFDRCIMQ HMMVHEQFTR 

       130        140        150        160        170        180 
FFHGFRRDSH PMAVMVACLG AMSAFYHDSI DIKDAQQRMI AAIRLISKVP TLAAMAYKYS 

       190        200        210        220        230        240 
IGQAFVYPRN DLSYAANFLH MCFSVPCEEY KINPVLSRAM DRIFTLHADH EQNASTSTVR 

       250        260        270        280        290        300 
LVGSSGANPF ACIAAGVACL WGPAHGGANE ACLKMLQKIG SVERIPEFIA RAKDKNDPFR 

       310        320        330        340        350        360 
LMGFGHRVYK NYDPRAKIMQ QTCHEVLKEL NIQDDPLLDI AIALENTALN DEYFIEKKLY 

       370        380        390        400        410        420 
PNVDFYSGIT LKALGFPTEM FTVLFALARS IGWVAQWKEM IEDPAQKIGR PRQLYTGYAA 

       430 
REYVSIDKRI SKNKMTTQ 

« Hide

References

« Hide 'large scale' references
[1]"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae."
Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E.
Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Toulouse.
[2]"Comparison of partial citrate synthase gene (gltA) sequences for phylogenetic analysis of Bartonella species."
Birtles R.J., Raoult D.
Int. J. Syst. Bacteriol. 46:891-897(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-379.
Strain: ATCC VR-358 / Fuller / CIP 107027.
[3]"Bartonella species characterization: citrate synthase (gltA) PCR product sequence analysis."
Jones D.C., Regnery R., Bowen M.
Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 268-379.
Strain: ATCC VR-358 / Fuller / CIP 107027.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX897700 Genomic DNA. Translation: CAF26174.1.
Z70014 Genomic DNA. Translation: CAA93836.1.
U28073 Genomic DNA. Translation: AAA74978.1.
RefSeqYP_032322.1. NC_005955.1.

3D structure databases

ProteinModelPortalP51034.
SMRP51034. Positions 2-429.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING283165.BQ06850.

Proteomic databases

PRIDEP51034.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAF26174; CAF26174; BQ06850.
GeneID2867054.
KEGGbqu:BQ06850.
PATRIC31952667. VBIBarQui58630_0759.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0372.
HOGENOMHOG000021224.
KOK01647.
OMAKETCDEV.
OrthoDBEOG6P8TP4.

Enzyme and pathway databases

BioCycBQUI283165:GHZA-684-MONOMER.
UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-II.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01798. cit_synth_I. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_BARQU
AccessionPrimary (citable) accession number: P51034
Secondary accession number(s): Q6FZN8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways