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P51033

- CISY_BARHE

UniProt

P51033 - CISY_BARHE

Protein

Citrate synthase

Gene

gltA

Organism
Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei306 – 3061PROSITE-ProRule annotation
    Active sitei364 – 3641PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciBHEN283166:GIVZ-637-MONOMER.
    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase (EC:2.3.3.16)
    Gene namesi
    Name:gltA
    Ordered Locus Names:BH06380
    OrganismiBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
    Taxonomic identifieri283166 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000000421: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Citrate synthasePRO_0000169934Add
    BLAST

    Proteomic databases

    PRIDEiP51033.

    Interactioni

    Protein-protein interaction databases

    STRINGi283166.BH06380.

    Structurei

    3D structure databases

    ProteinModelPortaliP51033.
    SMRiP51033. Positions 2-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0372.
    HOGENOMiHOG000021224.
    KOiK01647.
    OMAiKETCDEV.
    OrthoDBiEOG6P8TP4.

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51033-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKNKAHITV NDKKIELSVR KGTLGPDVIE IASLYKETDT FTYDPGFTST    50
    ASCESKITYI DGNEGILLYR GYPIDQLAEK GDFLESCYLL LYGELPTKQE 100
    KIDFDRCIMQ HTMVHEQFAR FFHGFRRDSH PMAVMIACLG AMSAFYHDSI 150
    DITDPQQRMI ASIRLISKVP TLAAMAYKYS IGQAFVYPRN DLSYAANFLR 200
    MCFSVPCEEY KINPVLTRAM DRIFTLHADH EQNASTSTVR LAGSSGANPF 250
    ACIAAGVACL WGPAHGGANE ACLKMLQEIG SVERIPEFIA RAKDKNDSFR 300
    LMGFGHRVYK NYDPRAKIMQ QTCHEVLKEL NIQNDPLLDI AITLENIALN 350
    DEYFIEKKLY PNVDFYSGIT LKALGFPTEM FTVLFALARS VGWVAQWKEM 400
    IEDPAQKISR PRQLYTGYAA REYIPIDKRV N 431
    Length:431
    Mass (Da):48,802
    Last modified:October 1, 1996 - v1
    Checksum:iDD40B8DEA70C2102
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38987 Genomic DNA. Translation: AAA87325.1.
    BX897699 Genomic DNA. Translation: CAF27442.1.
    PIRiI40044.
    RefSeqiWP_011180562.1. NC_005956.1.
    YP_033467.1. NC_005956.1.

    Genome annotation databases

    EnsemblBacteriaiCAF27442; CAF27442; BH06380.
    GeneIDi2864749.
    KEGGibhe:BH06380.
    PATRICi20545093. VBIBarHen29080_0695.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38987 Genomic DNA. Translation: AAA87325.1 .
    BX897699 Genomic DNA. Translation: CAF27442.1 .
    PIRi I40044.
    RefSeqi WP_011180562.1. NC_005956.1.
    YP_033467.1. NC_005956.1.

    3D structure databases

    ProteinModelPortali P51033.
    SMRi P51033. Positions 2-429.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 283166.BH06380.

    Proteomic databases

    PRIDEi P51033.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF27442 ; CAF27442 ; BH06380 .
    GeneIDi 2864749.
    KEGGi bhe:BH06380.
    PATRICi 20545093. VBIBarHen29080_0695.

    Phylogenomic databases

    eggNOGi COG0372.
    HOGENOMi HOG000021224.
    KOi K01647.
    OMAi KETCDEV.
    OrthoDBi EOG6P8TP4.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .
    BioCyci BHEN283166:GIVZ-637-MONOMER.

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differentiation of Bartonella-like isolates at the species level by PCR-restriction fragment length polymorphism in the citrate synthase gene."
      Norman A.F., Regnery R., Jameson P., Greene C., Krause D.C.
      J. Clin. Microbiol. 33:1797-1803(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 49882 / Houston 1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49882 / Houston 1.

    Entry informationi

    Entry nameiCISY_BARHE
    AccessioniPrimary (citable) accession number: P51033
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3