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P51033 (CISY_BARHE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.1
Gene names
Name:gltA
Ordered Locus Names:BH06380
OrganismBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae) [Complete proteome] [HAMAP]
Taxonomic identifier283166 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431Citrate synthase
PRO_0000169934

Sites

Active site3061 By similarity
Active site3641 By similarity

Sequences

Sequence LengthMass (Da)Tools
P51033 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: DD40B8DEA70C2102

FASTA43148,802
        10         20         30         40         50         60 
MSKNKAHITV NDKKIELSVR KGTLGPDVIE IASLYKETDT FTYDPGFTST ASCESKITYI 

        70         80         90        100        110        120 
DGNEGILLYR GYPIDQLAEK GDFLESCYLL LYGELPTKQE KIDFDRCIMQ HTMVHEQFAR 

       130        140        150        160        170        180 
FFHGFRRDSH PMAVMIACLG AMSAFYHDSI DITDPQQRMI ASIRLISKVP TLAAMAYKYS 

       190        200        210        220        230        240 
IGQAFVYPRN DLSYAANFLR MCFSVPCEEY KINPVLTRAM DRIFTLHADH EQNASTSTVR 

       250        260        270        280        290        300 
LAGSSGANPF ACIAAGVACL WGPAHGGANE ACLKMLQEIG SVERIPEFIA RAKDKNDSFR 

       310        320        330        340        350        360 
LMGFGHRVYK NYDPRAKIMQ QTCHEVLKEL NIQNDPLLDI AITLENIALN DEYFIEKKLY 

       370        380        390        400        410        420 
PNVDFYSGIT LKALGFPTEM FTVLFALARS VGWVAQWKEM IEDPAQKISR PRQLYTGYAA 

       430 
REYIPIDKRV N 

« Hide

References

« Hide 'large scale' references
[1]"Differentiation of Bartonella-like isolates at the species level by PCR-restriction fragment length polymorphism in the citrate synthase gene."
Norman A.F., Regnery R., Jameson P., Greene C., Krause D.C.
J. Clin. Microbiol. 33:1797-1803(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 49882 / Houston 1.
[2]"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae."
Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E.
Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L38987 Genomic DNA. Translation: AAA87325.1.
BX897699 Genomic DNA. Translation: CAF27442.1.
PIRI40044.
RefSeqYP_033467.1. NC_005956.1.

3D structure databases

ProteinModelPortalP51033.
SMRP51033. Positions 2-429.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING283166.BH06380.

Proteomic databases

PRIDEP51033.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAF27442; CAF27442; BH06380.
GeneID2864749.
KEGGbhe:BH06380.
PATRIC20545093. VBIBarHen29080_0695.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0372.
HOGENOMHOG000021224.
KOK01647.
OMAVERIPEF.
OrthoDBEOG6P8TP4.
ProtClustDBPRK05614.

Enzyme and pathway databases

BioCycBHEN283166:GIVZ-637-MONOMER.
UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-II.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01798. cit_synth_I. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_BARHE
AccessionPrimary (citable) accession number: P51033
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 13, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways