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Protein

Citrate synthase

Gene

gltA

Organism
Bartonella bacilliformis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei248 – 2481PROSITE-ProRule annotation
Active sitei306 – 3061PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
OrganismiBartonella bacilliformis
Taxonomic identifieri774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›321›321Citrate synthasePRO_0000169931Add
BLAST

Proteomic databases

PRIDEiP51031.

Structurei

3D structure databases

ProteinModelPortaliP51031.
SMRiP51031. Positions 1-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P51031-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
YIDGDEGILL YHGYSIDQLA ENGDFLETCY LLLYGELPNK QQKIDFDRCI
60 70 80 90 100
MRHTMVHEQF ARFFHGFRRD SHPMAVMVAC LGAMSAFYHD SINITDPQQR
110 120 130 140 150
MIASIRLISK VPTLAAMAYK YSIGQPFVYP RNDLNYATNF LHMCFSVPCE
160 170 180 190 200
EHKISPVIAR AMDRIFTLHA DHEQNASTST VRLAGSSGAN PYACIAAGVA
210 220 230 240 250
CLWGPAHGGA NEACLKMLQE IGSVKKIPEF IARAKDKNDP FRLMGFGHRV
260 270 280 290 300
YKNYDPRAKI MQKTCHEVLQ ELNIQDDPLL DIAMELEHIA LNDEYFINKK
310 320
LYPNVDFYSG ITLKALGFPT E
Length:321
Mass (Da):36,372
Last modified:November 1, 1997 - v2
Checksum:iD61068C82AB6B550
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Sequence conflicti229 – 2291E → Q in AAA74976 (Ref. 2) Curated
Sequence conflicti270 – 2701Q → K in AAA74976 (Ref. 2) Curated
Sequence conflicti277 – 2771D → N in AAA74976 (Ref. 2) Curated
Sequence conflicti280 – 2801L → F in AAA74976 (Ref. 2) Curated
Non-terminal residuei321 – 3211

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70021 Genomic DNA. Translation: CAA93843.1.
U28076 Genomic DNA. Translation: AAA74976.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70021 Genomic DNA. Translation: CAA93843.1.
U28076 Genomic DNA. Translation: AAA74976.1.

3D structure databases

ProteinModelPortaliP51031.
SMRiP51031. Positions 1-320.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP51031.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparison of partial citrate synthase gene (gltA) sequences for phylogenetic analysis of Bartonella species."
    Birtles R.J., Raoult D.
    Int. J. Syst. Bacteriol. 46:891-897(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-303.
    Strain: LA6.3.
  2. Jones D.C., Regnery R., Bowen M.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-321.
    Strain: KC584 / ATCC 35686.

Entry informationi

Entry nameiCISY_BARBA
AccessioniPrimary (citable) accession number: P51031
Secondary accession number(s): Q59184
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: October 1, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.