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P51031 (CISY_BARBA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.16
Gene names
Name:gltA
OrganismBartonella bacilliformis
Taxonomic identifier774 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Protein attributes

Sequence length321 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›321›321Citrate synthase
PRO_0000169931

Sites

Active site2481 By similarity
Active site3061 By similarity

Experimental info

Sequence conflict2291E → Q in AAA74976. Ref.2
Sequence conflict2701Q → K in AAA74976. Ref.2
Sequence conflict2771D → N in AAA74976. Ref.2
Sequence conflict2801L → F in AAA74976. Ref.2
Non-terminal residue11
Non-terminal residue3211

Sequences

Sequence LengthMass (Da)Tools
P51031 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: D61068C82AB6B550

FASTA32136,372
        10         20         30         40         50         60 
YIDGDEGILL YHGYSIDQLA ENGDFLETCY LLLYGELPNK QQKIDFDRCI MRHTMVHEQF 

        70         80         90        100        110        120 
ARFFHGFRRD SHPMAVMVAC LGAMSAFYHD SINITDPQQR MIASIRLISK VPTLAAMAYK 

       130        140        150        160        170        180 
YSIGQPFVYP RNDLNYATNF LHMCFSVPCE EHKISPVIAR AMDRIFTLHA DHEQNASTST 

       190        200        210        220        230        240 
VRLAGSSGAN PYACIAAGVA CLWGPAHGGA NEACLKMLQE IGSVKKIPEF IARAKDKNDP 

       250        260        270        280        290        300 
FRLMGFGHRV YKNYDPRAKI MQKTCHEVLQ ELNIQDDPLL DIAMELEHIA LNDEYFINKK 

       310        320 
LYPNVDFYSG ITLKALGFPT E 

« Hide

References

[1]"Comparison of partial citrate synthase gene (gltA) sequences for phylogenetic analysis of Bartonella species."
Birtles R.J., Raoult D.
Int. J. Syst. Bacteriol. 46:891-897(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-303.
Strain: LA6.3.
[2]Jones D.C., Regnery R., Bowen M.
Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-321.
Strain: KC584 / ATCC 35686.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z70021 Genomic DNA. Translation: CAA93843.1.
U28076 Genomic DNA. Translation: AAA74976.1.

3D structure databases

ProteinModelPortalP51031.
SMRP51031. Positions 1-320.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP51031.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-II.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01798. cit_synth_I. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_BARBA
AccessionPrimary (citable) accession number: P51031
Secondary accession number(s): Q59184
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways