Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Citrate synthase

Gene

gltA

Organism
Bartonella bacilliformis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Citrate synthase (gltA)
  2. no protein annotated in this organism
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei248PROSITE-ProRule annotation1
Active sitei306PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
OrganismiBartonella bacilliformis
Taxonomic identifieri774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000169931‹1 – ›321Citrate synthaseAdd BLAST›321

Proteomic databases

PRIDEiP51031.

Interactioni

Protein-protein interaction databases

STRINGi360095.BARBAKC583_0599.

Structurei

3D structure databases

ProteinModelPortaliP51031.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105BZN. Bacteria.
COG0372. LUCA.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P51031-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
YIDGDEGILL YHGYSIDQLA ENGDFLETCY LLLYGELPNK QQKIDFDRCI
60 70 80 90 100
MRHTMVHEQF ARFFHGFRRD SHPMAVMVAC LGAMSAFYHD SINITDPQQR
110 120 130 140 150
MIASIRLISK VPTLAAMAYK YSIGQPFVYP RNDLNYATNF LHMCFSVPCE
160 170 180 190 200
EHKISPVIAR AMDRIFTLHA DHEQNASTST VRLAGSSGAN PYACIAAGVA
210 220 230 240 250
CLWGPAHGGA NEACLKMLQE IGSVKKIPEF IARAKDKNDP FRLMGFGHRV
260 270 280 290 300
YKNYDPRAKI MQKTCHEVLQ ELNIQDDPLL DIAMELEHIA LNDEYFINKK
310 320
LYPNVDFYSG ITLKALGFPT E
Length:321
Mass (Da):36,372
Last modified:November 1, 1997 - v2
Checksum:iD61068C82AB6B550
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti229E → Q in AAA74976 (Ref. 2) Curated1
Sequence conflicti270Q → K in AAA74976 (Ref. 2) Curated1
Sequence conflicti277D → N in AAA74976 (Ref. 2) Curated1
Sequence conflicti280L → F in AAA74976 (Ref. 2) Curated1
Non-terminal residuei3211

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70021 Genomic DNA. Translation: CAA93843.1.
U28076 Genomic DNA. Translation: AAA74976.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70021 Genomic DNA. Translation: CAA93843.1.
U28076 Genomic DNA. Translation: AAA74976.1.

3D structure databases

ProteinModelPortaliP51031.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360095.BARBAKC583_0599.

Proteomic databases

PRIDEiP51031.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105BZN. Bacteria.
COG0372. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCISY_BARBA
AccessioniPrimary (citable) accession number: P51031
Secondary accession number(s): Q59184
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: October 5, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.