P51029 (WNT8B_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Wnt-8b

Gene names

Name:	wnt8b
Synonyms:	wnt-8b

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May play a role in the establishment of polarity in the nervous system.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Tissue specificity	Hindbrain r1, 2 and 5.
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway involved in forebrain neuron fate commitment Inferred from Biological aspect of Ancestor. Source: RefGenome anterior/posterior pattern specification Inferred from Biological aspect of Ancestor. Source: RefGenome axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome endoderm development Inferred from Biological aspect of Ancestor. Source: RefGenome eye development Inferred from direct assay. Source: ZFIN hypothalamus development Inferred from mutant phenotype. Source: ZFIN negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway Inferred from mutant phenotype. Source: ZFIN otic placode formation Inferred from mutant phenotype. Source: ZFIN positive regulation of gene expression Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular component	extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 358	335	Protein Wnt-8b		PRO_0000041452
Amino acid modifications
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Glycosylation	260	1	N-linked (GlcNAc...) Potential
	Glycosylation	279	1	N-linked (GlcNAc...) Potential
	Glycosylation	345	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P51029 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 3CCB93B0772BF4A8	FASTA	358	40,343
	10 20 30 40 50 60 MFMHLEVYYY AFILMAHMKT CCGWSVNNFL MTGPKAYLIY SSSVAAGAQS GIEECKYQFA 70 80 90 100 110 120 WDRWKCPERA LQLSTHSGLR SANRETAFFH AISSAGVMYT LTRNCSLGDF DNCGCDDTRN 130 140 150 160 170 180 GQRGGQGWLW GGCSDNVGFG EVISKQFVDA LETGQDARAA MNLHNNEVGR KAVKGTMQRT 190 200 210 220 230 240 CKCHGVSGSC TTQTCWLQLP EFREVGNYLK EKYHRAVKVD LLRGAGNSAA SRGAIAETFN 250 260 270 280 290 300 SISRKELVHL EDSPDYCLEN RTLGLPGTEG RECLRKGKNL SKWEKRTCKR LCGDCGLAVE 310 320 330 340 350 ERRAETVSSC NCKFHWCCAV KCEQCRKTVT KYYCVKRSKR VKNDNASRRK SYRLKKKH

References

[1]	"Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways." Kelly G.M., Erezyilmaz D.F., Greenstein P.E., Moon R.T. Development 121:1787-1799(1995) [PubMed: 7600994] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10870 mRNA. Translation: AAC59698.1.
IPI	IPI00508467.
PIR	I50506.
RefSeq	NP_571034.1. NM_130959.1.
UniGene	Dr.623.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P51029.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	30144.
KEGG	dre:30144.
Organism-specific databases
CTD	7479.
ZFIN	ZDB-GENE-990415-279. wnt8b.
Phylogenomic databases
eggNOG	fiNOG05359.
GeneTree	ENSGT00600000084119.
HOGENOM	HBG446188.
HOVERGEN	HBG001595.
InParanoid	P51029.
OrthoDB	EOG4CNQRC.
Gene expression databases
ArrayExpress	P51029.
Bgee	P51029.
Family and domain databases
InterPro	IPR005817. Wnt. IPR013301. Wnt8. IPR018161. Wnt_grthfactor_CS. [Graphical view]
KO	K00714.
PANTHER	PTHR12027. Wnt. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01892. WNT8PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

WNT8B_DANRE

Accession

Primary (citable) accession number: P51029

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program