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Reviewed, UniProtKB/Swiss-Prot P51019 (HOA2_PSEPU)

Last modified February 9, 2010. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
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Names and originHide

Protein namesRecommended name:
4-hydroxy-2-oxovalerate aldolase
Short name=HOA
EC=4.1.3.39
Alternative name(s):
4-hydroxy-2-oxopentanoate aldolase
4-hydroxy-2-keto-pentanoic acid aldolase
Gene names
Name:xylK
Encoded onPlasmid TOL pWW0
OrganismPseudomonas putida
Taxonomic identifier303 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas
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Protein attributesHide

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology.
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General annotation (Comments)Hide

Function

Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01656

Catalytic activity

4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate. HAMAP MF_01656

Pathway

Xenobiotic degradation; toluene degradation. HAMAP MF_01656

Sequence similarities

Belongs to the 4-hydroxy-2-oxovalerate aldolase family.

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OntologiesHide

Keywords
   Biological processAromatic hydrocarbons catabolism
   Molecular functionLyase
   Technical termPlasmid
Gene Ontology (GO)
   Biological processaromatic compound catabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular function4-hydroxy-2-oxovalerate aldolase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...
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Sequence annotation (Features)Hide

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3453454-hydroxy-2-oxovalerate aldolase HAMAP MF_01656
PRO_0000066056
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SequencesHide

Sequence LengthMass (Da)Tools
P51019-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 467C928D1A1E09F1

FASTA34537,444
        10         20         30         40         50         60 
MTFNPGKKLY ISDVTLRDGS HAIRHQYSIQ NVQDIARALD KARVDSIEVT HGDGLQGSSF 

        70         80         90        100        110        120 
NYGFGAHSDL EWIEAAADVI QHARVTVLLV PGIGTVHDLK AAYDAGARSV RVATHCTEAD 

       130        140        150        160        170        180 
VSRQHIEYAR ELGMDTVGFL MMSHMIPAEQ LAAQGKLMET YGAQCIYMAD SGGAMNMNDI 

       190        200        210        220        230        240 
RDRMRAFKAV LNPQTQTGMH AHHNLSLGVA NSIIAVEEGC DRIDASLAGM GAGAGNAPLE 

       250        260        270        280        290        300 
VFIAAAERLG WNHGTDLYTL MDAADDIVRP LQDRPVRVDR ETLGLGYAGV YSSFLRHAEV 

       310        320        330        340 
AAAKYGLKTL DILVELGRRR MVGGQEDMIV DVALDLLAAR KEQQA

« Hide

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ReferencesHide

[1]"Comparison of the nucleotide sequences of the meta-cleavage pathway genes of TOL plasmid pWW0 from Pseudomonas putida with other meta-cleavage genes suggests that both single and multiple nucleotide substitutions contribute to enzyme evolution."
Harayama S., Rekik M.
Mol. Gen. Genet. 239:81-89(1993) [PubMed: 8510667] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
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Cross-referencesHide

Sequence databases

EMBL
GenBank
DDBJ		M94186 Genomic DNA. Translation: AAA25692.1.
PIRS35223.
RefSeqNP_542861.1.

3D structure databases

SMRP51019. Positions 2-341.
ModBaseSearch...

Genome annotation databases

GeneID1218752.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-3404.

Family and domain databases

HAMAPMF_01656. HOA.
[Tree]
InterProIPR017629. 4OH_2_O-val_aldolase.
IPR013785. Aldolase_TIM.
IPR012425. DmpG_comm.
IPR000891. PYR_CT.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF07836. DmpG_comm. 1 hit.
PF00682. HMGL-like. 1 hit.
[Graphical view]
ProDomPD005364. DmpG_comm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR03217. 4OH_2_O_val_ald. 1 hit.
PROSITEPS50991. PYR_CT. 1 hit.
[Graphical view]
ProtoNetSearch...
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Entry informationHide

Entry nameHOA2_PSEPU
AccessionPrimary (citable) accession number: P51019
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 9, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)
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Relevant documentsHide

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents