ID   NAHM_PSEPU              Reviewed;         346 AA.
AC   P51017;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 37.
DE   RecName: Full=4-hydroxy-2-oxovalerate aldolase;
DE            Short=HOA;
DE            EC=4.1.3.39;
GN   Name=nahM;
OS   Pseudomonas putida.
OG   Plasmid pWW60-22.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NCIMB 9816;
RX   MEDLINE=96118704; PubMed=7496535;
RA   Platt A., Shingler V., Taylor S.C., Williams P.A.;
RT   "The 4-hydroxy-2-oxovalerate aldolase and acetaldehyde dehydrogenase
RT   (acylating) encoded by the nahM and nahO genes of the naphthalene
RT   catabolic plasmid pWW60-22 provide further evidence of conservation of
RT   meta-cleavage pathway gene sequences.";
RL   Microbiology 141:2223-2233(1995).
CC   -!- FUNCTION: Catalyzes the production of pyruvate and acetaldehyde
CC       from 4-hydroxy-2-oxovalerate.
CC   -!- CATALYTIC ACTIVITY: 4-hydroxy-2-oxopentanoate = acetaldehyde +
CC       pyruvate.
CC   -!- PATHWAY: Aromatic compound metabolism; salicylic acid degradation.
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DR   EMBL; U13232; AAA89107.1; -; Genomic_DNA.
DR   RefSeq; NP_863098.1; -.
DR   HSSP; P51016; 1NVM.
DR   GeneID; 1343200; -.
DR   BRENDA; 4.1.3.39; 403.
DR   GO; GO:0008701; F:4-hydroxy-2-oxovalerate aldolase activity; IEA:EC.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR017629; 4OH_2_O-val_aldolase.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR012425; DmpG_comm.
DR   InterPro; IPR000891; PYR_CT.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF07836; DmpG_comm; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   TIGRFAMs; TIGR03217; 4OH_2_O_val_ald; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   4: Predicted;
KW   Aromatic hydrocarbons catabolism; Lyase; Plasmid.
FT   CHAIN         1    346       4-hydroxy-2-oxovalerate aldolase.
FT                                /FTId=PRO_0000096706.
SQ   SEQUENCE   346 AA;  37102 MW;  65963EE93E4BAB7F CRC64;
     MNLHGKSVIL HDMSLRDGMH AKRHQISLEQ MVAVATGLDQ AGMPLIEITH GDGLGGRSIN
     YGFPAHSDEE YLRAVIPQLK QAKVSALLLP GIGTVDHLKM ALDCGVSTIR VATHCTEADV
     SEQHIGMARK LGVDTVGFLM MAHMISAEKV LEQAKLMESY GANCIYCTDS AGYMLPDEVS
     EKIGLLRAEL NPATEVGFHG HHNMGMAIAN SLAAIEAGAA RIDGSVAGLG AGAGNTPLEV
     FVAVCKRMGV ETGIDLYKIM DVAEDLVVPM MDQPIRVDRD ALTLGYAGVY SSFLLFAQRA
     EKKYGVSARD ILVELGRRGT VGGQEDMIED LALDMARARQ QQKVSA
//