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Reviewed, UniProtKB/Swiss-Prot P51011 (LDHD_LEUMC)

Last modified November 25, 2008. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    D-lactate dehydrogenase
      Short name=D-LDH
    EC=1.1.1.28
Alternative name(s):
    D-specific D-2-hydroxyacid dehydrogenase
OrganismLeuconostoc mesenteroides subsp. cremoris
Taxonomic identifier33965 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesLeuconostoc

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

(R)-lactate + NAD(+) = pyruvate + NADH.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Ontologies

Keywords

   LigandNAD
   Molecular functionOxidoreductase

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionD-lactate dehydrogenase activity

Inferred from electronic annotation. Source: EC

NAD binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331D-lactate dehydrogenase
PRO_0000075957

Sites

Active site2351 By similarity
Active site2641 By similarity
Active site2961Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
P51011-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 0A63C462303672D8

FASTA33136,316
        10         20         30         40         50         60 
MKIFAYGIRD DEKPSLEEWK AANPEIEVDY TQELLTPETA KLAEGSDSAV VYQQLDYTRE 

        70         80         90        100        110        120 
TLTALANVGV TNLSLRNVGT DNIDFDAARE FNFNISNVPV YSPNAIAEHS MLQLSRLLRR 

       130        140        150        160        170        180 
TKALDAKIAK RDLRWAPTTG REMRMQTVGV IGTGHIGRVA INILKGFGAK VIAYDKYPNA 

       190        200        210        220        230        240 
ELQAEGLYVD TLDELYAQAD AISLYVPGVP ENHHLINADA IAKMKDGVVI MNAARGNLMD 

       250        260        270        280        290        300 
IDAIIDGLNS GKISDFGMDV YENEVACSMK IGLVKNSPDA KIADLIAREN VMITPHTAFY 

       310        320        330 
TTKAVLEMVH QSFDAAVAFA KGEKPAIAVE Y 

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References

[1]"Purification, properties and DNA sequence of the D-lactate dehydrogenase from Leuconostoc mesenteroides subsp. cremoris."
Dartois V., Phalip V., Schmitt P., Divies C.
Res. Microbiol. 146:291-302(1995) [PubMed: 7569323] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 195.

Cross-references

Sequence databases

L29327 Genomic DNA. Translation: AAA99506.1.

3D structure databases

HSSPHSSP built from PDB template 2DLD based on UniProtKB P30901.
ModBaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MON-13061.

Family and domain databases

InterProIPR006139. D-isomer_2_OHA_DHase.
IPR006140. D-isomer_2_OHA_DHase_NAD-bd.
IPR016040. NAD(P)-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. False negative.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLDHD_LEUMC
AccessionPrimary (citable) accession number: P51011
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 25, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents