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P51011 (LDHD_LEUMC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 28, 2011. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-lactate dehydrogenase

Short name=D-LDH
EC=1.1.1.28
Alternative name(s):
D-specific D-2-hydroxyacid dehydrogenase
OrganismLeuconostoc mesenteroides subsp. cremoris
Taxonomic identifier33965 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesLeuconostoc

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-lactate + NAD+ = pyruvate + NADH.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Molecular functionD-lactate dehydrogenase activity

Inferred from electronic annotation. Source: EC

NAD binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331D-lactate dehydrogenase
PRO_0000075957

Regions

Nucleotide binding155 – 1562NAD By similarity
Nucleotide binding233 – 2353NAD By similarity
Nucleotide binding296 – 2994NAD By similarity

Sites

Active site2351 By similarity
Active site2641 By similarity
Active site2961Proton donor By similarity
Binding site2591NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P51011 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 0A63C462303672D8

FASTA33136,316
        10         20         30         40         50         60 
MKIFAYGIRD DEKPSLEEWK AANPEIEVDY TQELLTPETA KLAEGSDSAV VYQQLDYTRE 

        70         80         90        100        110        120 
TLTALANVGV TNLSLRNVGT DNIDFDAARE FNFNISNVPV YSPNAIAEHS MLQLSRLLRR 

       130        140        150        160        170        180 
TKALDAKIAK RDLRWAPTTG REMRMQTVGV IGTGHIGRVA INILKGFGAK VIAYDKYPNA 

       190        200        210        220        230        240 
ELQAEGLYVD TLDELYAQAD AISLYVPGVP ENHHLINADA IAKMKDGVVI MNAARGNLMD 

       250        260        270        280        290        300 
IDAIIDGLNS GKISDFGMDV YENEVACSMK IGLVKNSPDA KIADLIAREN VMITPHTAFY 

       310        320        330 
TTKAVLEMVH QSFDAAVAFA KGEKPAIAVE Y 

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References

[1]"Purification, properties and DNA sequence of the D-lactate dehydrogenase from Leuconostoc mesenteroides subsp. cremoris."
Dartois V., Phalip V., Schmitt P., Divies C.
Res. Microbiol. 146:291-302(1995) [PubMed: 7569323] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 195.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L29327 Genomic DNA. Translation: AAA99506.1.

3D structure databases

ProteinModelPortalP51011.
SMRP51011. Positions 2-325.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-13061.

Family and domain databases

InterProIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. False negative.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLDHD_LEUMC
AccessionPrimary (citable) accession number: P51011
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 28, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families