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Protein

Transcriptional activator protein FnrL

Gene

fnrL

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Anaerobic regulatory protein; transcriptional activator of hemA. Appears to regulate other genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi191 – 21020H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Iron

Enzyme and pathway databases

BioCyciRSPH272943:GJAS-2364-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator protein FnrL
Gene namesi
Name:fnrL
Ordered Locus Names:RHOS4_23060
ORF Names:RSP_0698
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000002703 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Transcriptional activator protein FnrLPRO_0000100180Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_0698.

Structurei

3D structure databases

ProteinModelPortaliP51007.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini154 – 23279HTH crp-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000186462.
KOiK01420.
OMAiVSRSFTK.
OrthoDBiEOG6TBHH3.
PhylomeDBiP51007.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51007-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLHEVPTIL HRCGDCPIRH RAVCARCDSE ELATLEQIKY YRSYQAGQTV
60 70 80 90 100
IWSGDKMDFV ASVVTGIATL TQTMEDGRRQ MVGLLLPSDF VGRPGRQTVA
110 120 130 140 150
YDVTATTDLL MCCFRRKPFE EMMQKTPHVG QRLLEMTLDE LDAAREWMLL
160 170 180 190 200
LGRKTAREKI ASLLAIIARR DAALKLRESN GPMTFDLPLT REEMADYLGL
210 220 230 240
TLETVSRQVS ALKRDGVIAL EGKRHVIVTD FARLLEEAGD DSDGGLPV
Length:248
Mass (Da):27,800
Last modified:October 1, 1996 - v1
Checksum:i788F5BB365AE7DAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49746 Genomic DNA. Translation: CAA89820.1.
CP000143 Genomic DNA. Translation: ABA79874.1.
RefSeqiWP_002720880.1. NZ_AKVW01000001.1.
YP_353775.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA79874; ABA79874; RSP_0698.
GeneIDi3718176.
KEGGirsp:RSP_0698.
PATRICi23154559. VBIRhoSph57909_2650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49746 Genomic DNA. Translation: CAA89820.1.
CP000143 Genomic DNA. Translation: ABA79874.1.
RefSeqiWP_002720880.1. NZ_AKVW01000001.1.
YP_353775.1. NC_007493.2.

3D structure databases

ProteinModelPortaliP51007.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272943.RSP_0698.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA79874; ABA79874; RSP_0698.
GeneIDi3718176.
KEGGirsp:RSP_0698.
PATRICi23154559. VBIRhoSph57909_2650.

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000186462.
KOiK01420.
OMAiVSRSFTK.
OrthoDBiEOG6TBHH3.
PhylomeDBiP51007.

Enzyme and pathway databases

BioCyciRSPH272943:GJAS-2364-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Aerobic and anaerobic regulation in Rhodobacter sphaeroides 2.4.1: the role of the fnrL gene."
    Zeilstra-Ryalls J.H., Kaplan S.
    J. Bacteriol. 177:6422-6431(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Entry informationi

Entry nameiFNRL_RHOS4
AccessioniPrimary (citable) accession number: P51007
Secondary accession number(s): Q3J010
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 22, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Possesses 4 cysteines which may bind a metal ion (possibly iron).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.