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P51005

- PAPO2_XENLA

UniProt

P51005 - PAPO2_XENLA

Protein

Poly(A) polymerase alpha-B

Gene

papola-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor (CPSF).

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. RNA polyadenylation Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase alpha-B (EC:2.7.7.19)
    Short name:
    PAP-alpha-B
    Alternative name(s):
    Polynucleotide adenylyltransferase alpha-B
    Gene namesi
    Name:papola-b
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-944355. papola.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484Poly(A) polymerase alpha-BPRO_0000051615Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP51005.
    SMRiP51005. Positions 1-248.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi240 – 25718Nuclear localization signal 1By similarityAdd
    BLAST
    Motifi392 – 40716Nuclear localization signal 2By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the poly(A) polymerase family.Curated

    Phylogenomic databases

    HOVERGENiHBG053502.

    Family and domain databases

    Gene3Di3.30.70.590. 1 hit.
    InterProiIPR011068. NuclTrfase_I_C.
    IPR007012. PolA_pol_cen_dom.
    IPR007010. PolA_pol_RNA-bd_dom.
    IPR014492. PolyA_polymerase.
    [Graphical view]
    PfamiPF04928. PAP_central. 1 hit.
    PF04926. PAP_RNA-bind. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018425. PolyA_polymerase. 1 hit.
    SUPFAMiSSF55003. SSF55003. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P51005-1 [UniParc]FASTAAdd to Basket

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    MLVARTCQLY PNAIASTLVH KFFLVFSKWE WPNPVLLKQP EECNLNLPVW    50
    DPRVNPSDRY HLMPIITPAY PQQNSTYNVS VSTRAVMVEE FKQGLAITDE 100
    ILLVKAEWSK LFDAPNFFQK YKHYILLLAS APTEKQRLEW VGLVESKIRI 150
    LVGSLEKNEF ITLAHVNPQS FPSPSENSEK EEFRTMWVIG LVFKKMENSE 200
    NLSVDLTYDI QSFTDTVYRQ AINSKMFETE IKIAAMHVKR KQLHQLLPSH 250
    VLPKKKKHSV EGVKLVSLND SSIDLSVDSD NSMSVPSPTN ATRTSPLNST 300
    GLSQGNSPAT PVSLSVTNTQ ATDVMVPQNN STENSGGSLN ESIPETATHP 350
    AFSSTPRPLV TRVVSSMPLV NQVQKPVTNT VTKMPSPVAG VKRTSSPTNE 400
    ESPKKTKTEE DENDSSNSTE VDEQNKLEPE ELKEVHSEEK SSSPVPGALP 450
    SSQRSSSTDL SDISVLPATP IPVIKNSIKL RLNR 484
    Length:484
    Mass (Da):53,830
    Last modified:October 1, 1996 - v1
    Checksum:iD81361CF0D79B879
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19974 mRNA. Translation: AAC59746.1.
    UniGeneiXl.341.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19974 mRNA. Translation: AAC59746.1 .
    UniGenei Xl.341.

    3D structure databases

    ProteinModelPortali P51005.
    SMRi P51005. Positions 1-248.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Xenbasei XB-GENE-944355. papola.

    Phylogenomic databases

    HOVERGENi HBG053502.

    Family and domain databases

    Gene3Di 3.30.70.590. 1 hit.
    InterProi IPR011068. NuclTrfase_I_C.
    IPR007012. PolA_pol_cen_dom.
    IPR007010. PolA_pol_RNA-bd_dom.
    IPR014492. PolyA_polymerase.
    [Graphical view ]
    Pfami PF04928. PAP_central. 1 hit.
    PF04926. PAP_RNA-bind. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018425. PolyA_polymerase. 1 hit.
    SUPFAMi SSF55003. SSF55003. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Poly(A) polymerases in the nucleus and cytoplasm of frog oocytes: dynamic changes during oocyte maturation and early development."
      Ballantyne S., Bilger A., Astrom J., Virtanen A., Wickens M.
      RNA 1:64-78(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiPAPO2_XENLA
    AccessioniPrimary (citable) accession number: P51005
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3