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P51005 (PAPO2_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Poly(A) polymerase alpha-B

Short name=PAP-alpha-B
EC=2.7.7.19
Alternative name(s):
Polynucleotide adenylyltransferase alpha-B
Gene names
Name:papola-b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor (CPSF).

Catalytic activity

ATP + RNA(n) = diphosphate + RNA(n+1).

Subunit structure

Monomer By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the poly(A) polymerase family.

Ontologies

Keywords
   Biological processmRNA processing
   Cellular componentNucleus
   LigandATP-binding
Nucleotide-binding
RNA-binding
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processRNA polyadenylation

Inferred from electronic annotation. Source: InterPro

mRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

polynucleotide adenylyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 484484Poly(A) polymerase alpha-B
PRO_0000051615

Regions

Motif240 – 25718Nuclear localization signal 1 By similarity
Motif392 – 40716Nuclear localization signal 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P51005 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: D81361CF0D79B879

FASTA48453,830
        10         20         30         40         50         60 
MLVARTCQLY PNAIASTLVH KFFLVFSKWE WPNPVLLKQP EECNLNLPVW DPRVNPSDRY 

        70         80         90        100        110        120 
HLMPIITPAY PQQNSTYNVS VSTRAVMVEE FKQGLAITDE ILLVKAEWSK LFDAPNFFQK 

       130        140        150        160        170        180 
YKHYILLLAS APTEKQRLEW VGLVESKIRI LVGSLEKNEF ITLAHVNPQS FPSPSENSEK 

       190        200        210        220        230        240 
EEFRTMWVIG LVFKKMENSE NLSVDLTYDI QSFTDTVYRQ AINSKMFETE IKIAAMHVKR 

       250        260        270        280        290        300 
KQLHQLLPSH VLPKKKKHSV EGVKLVSLND SSIDLSVDSD NSMSVPSPTN ATRTSPLNST 

       310        320        330        340        350        360 
GLSQGNSPAT PVSLSVTNTQ ATDVMVPQNN STENSGGSLN ESIPETATHP AFSSTPRPLV 

       370        380        390        400        410        420 
TRVVSSMPLV NQVQKPVTNT VTKMPSPVAG VKRTSSPTNE ESPKKTKTEE DENDSSNSTE 

       430        440        450        460        470        480 
VDEQNKLEPE ELKEVHSEEK SSSPVPGALP SSQRSSSTDL SDISVLPATP IPVIKNSIKL 


RLNR 

« Hide

References

[1]"Poly(A) polymerases in the nucleus and cytoplasm of frog oocytes: dynamic changes during oocyte maturation and early development."
Ballantyne S., Bilger A., Astrom J., Virtanen A., Wickens M.
RNA 1:64-78(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19974 mRNA. Translation: AAC59746.1.
UniGeneXl.341.

3D structure databases

ProteinModelPortalP51005.
SMRP51005. Positions 1-248.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

XenbaseXB-GENE-944355. papola.

Phylogenomic databases

HOVERGENHBG053502.

Family and domain databases

Gene3D3.30.70.590. 1 hit.
InterProIPR011068. NuclTrfase_I_C.
IPR007012. PolA_pol_cen_dom.
IPR007010. PolA_pol_RNA-bd_dom.
IPR014492. PolyA_polymerase.
[Graphical view]
PfamPF04928. PAP_central. 1 hit.
PF04926. PAP_RNA-bind. 1 hit.
[Graphical view]
PIRSFPIRSF018425. PolyA_polymerase. 1 hit.
SUPFAMSSF55003. SSF55003. 1 hit.
ProtoNetSearch...

Entry information

Entry namePAPO2_XENLA
AccessionPrimary (citable) accession number: P51005
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families