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Protein

Poly(A) polymerase alpha-B

Gene

papola-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor (CPSF).

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase alpha-B (EC:2.7.7.19)
Short name:
PAP-alpha-B
Alternative name(s):
Polynucleotide adenylyltransferase alpha-B
Gene namesi
Name:papola-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-944355. papola.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Poly(A) polymerase alpha-BPRO_0000051615Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP51005.
SMRiP51005. Positions 1-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi240 – 25718Nuclear localization signal 1By similarityAdd
BLAST
Motifi392 – 40716Nuclear localization signal 2By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the poly(A) polymerase family.Curated

Phylogenomic databases

HOVERGENiHBG053502.

Family and domain databases

Gene3Di3.30.70.590. 1 hit.
InterProiIPR011068. NuclTrfase_I_C.
IPR007012. PolA_pol_cen_dom.
IPR007010. PolA_pol_RNA-bd_dom.
IPR014492. PolyA_polymerase.
[Graphical view]
PANTHERiPTHR10682. PTHR10682. 1 hit.
PfamiPF04928. PAP_central. 1 hit.
PF04926. PAP_RNA-bind. 1 hit.
[Graphical view]
PIRSFiPIRSF018425. PolyA_polymerase. 1 hit.
SUPFAMiSSF55003. SSF55003. 1 hit.

Sequencei

Sequence statusi: Complete.

P51005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVARTCQLY PNAIASTLVH KFFLVFSKWE WPNPVLLKQP EECNLNLPVW
60 70 80 90 100
DPRVNPSDRY HLMPIITPAY PQQNSTYNVS VSTRAVMVEE FKQGLAITDE
110 120 130 140 150
ILLVKAEWSK LFDAPNFFQK YKHYILLLAS APTEKQRLEW VGLVESKIRI
160 170 180 190 200
LVGSLEKNEF ITLAHVNPQS FPSPSENSEK EEFRTMWVIG LVFKKMENSE
210 220 230 240 250
NLSVDLTYDI QSFTDTVYRQ AINSKMFETE IKIAAMHVKR KQLHQLLPSH
260 270 280 290 300
VLPKKKKHSV EGVKLVSLND SSIDLSVDSD NSMSVPSPTN ATRTSPLNST
310 320 330 340 350
GLSQGNSPAT PVSLSVTNTQ ATDVMVPQNN STENSGGSLN ESIPETATHP
360 370 380 390 400
AFSSTPRPLV TRVVSSMPLV NQVQKPVTNT VTKMPSPVAG VKRTSSPTNE
410 420 430 440 450
ESPKKTKTEE DENDSSNSTE VDEQNKLEPE ELKEVHSEEK SSSPVPGALP
460 470 480
SSQRSSSTDL SDISVLPATP IPVIKNSIKL RLNR
Length:484
Mass (Da):53,830
Last modified:October 1, 1996 - v1
Checksum:iD81361CF0D79B879
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19974 mRNA. Translation: AAC59746.1.
UniGeneiXl.341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19974 mRNA. Translation: AAC59746.1.
UniGeneiXl.341.

3D structure databases

ProteinModelPortaliP51005.
SMRiP51005. Positions 1-248.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

XenbaseiXB-GENE-944355. papola.

Phylogenomic databases

HOVERGENiHBG053502.

Family and domain databases

Gene3Di3.30.70.590. 1 hit.
InterProiIPR011068. NuclTrfase_I_C.
IPR007012. PolA_pol_cen_dom.
IPR007010. PolA_pol_RNA-bd_dom.
IPR014492. PolyA_polymerase.
[Graphical view]
PANTHERiPTHR10682. PTHR10682. 1 hit.
PfamiPF04928. PAP_central. 1 hit.
PF04926. PAP_RNA-bind. 1 hit.
[Graphical view]
PIRSFiPIRSF018425. PolyA_polymerase. 1 hit.
SUPFAMiSSF55003. SSF55003. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Poly(A) polymerases in the nucleus and cytoplasm of frog oocytes: dynamic changes during oocyte maturation and early development."
    Ballantyne S., Bilger A., Astrom J., Virtanen A., Wickens M.
    RNA 1:64-78(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiPAPO2_XENLA
AccessioniPrimary (citable) accession number: P51005
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 22, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.