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Protein

T-complex protein 1 subunit delta

Gene

cct4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit delta
Short name:
TCP-1-delta
Alternative name(s):
CCT-delta
Gene namesi
Name:cct4
ORF Names:SPBC106.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC106.06
PomBaseiSPBC106.06 cct4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283431 – 527T-complex protein 1 subunit deltaAdd BLAST527

Proteomic databases

MaxQBiP50999
PaxDbiP50999
PRIDEiP50999

PTM databases

iPTMnetiP50999

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.Curated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276591, 7 interactors
IntActiP50999, 2 interactors
STRINGi4896.SPBC106.06.1

Structurei

3D structure databases

ProteinModelPortaliP50999
SMRiP50999
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

HOGENOMiHOG000226735
InParanoidiP50999
KOiK09496
OMAiQFCLSPP
OrthoDBiEOG092C1WYZ
PhylomeDBiP50999

Family and domain databases

CDDicd03338 TCP1_delta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012717 Chap_CCT_delta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02342 chap_CCT_delta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

P50999-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKAATVPVA FQDREKPQEV RLSNIMAARS VADAIRTSLG PKGMDKMIQT
60 70 80 90 100
GKGEVILTND GATILKHLSV LHPAAKMLVD LSAAQDVEAG DGTTSVVILA
110 120 130 140 150
GSMLACAEKL LKKGIHPTVI AESFQRAAGF TVDCMKENAL AIELSDRESL
160 170 180 190 200
LRAATTSLNS KIVSQYSNLL APIAVDAVLK VIDPRVATNV DLKDIRIVKK
210 220 230 240 250
LGGIIDDTEL IPGLALTQTA VKSAGGPTRI EKANIALIQF QLSPPKPDME
260 270 280 290 300
NQVVVNDYRQ MDKILKEERQ YLLNMCKKIK KAGANVILIQ KSILRDAVND
310 320 330 340 350
LALHFLAKLK IMVIKDIERD EVEFICKSTG CKPIADIESF AEDKLGHADL
360 370 380 390 400
VEETSSSGEK IVKFSGVKNA GKTVSILCRG ANLLTLEEAE RSLHDALCVI
410 420 430 440 450
RCLVKQRALI AGGGSPEIEA AQRLLEHARQ LEGREAICIR AFSEALEIIP
460 470 480 490 500
VTLAENAGLN AIQVVTELRS RHANGEKTAG INVRKGIVTN ILEENVLQPL
510 520
LVNISAIQLA AETTKMIMKI DDITLAR
Length:527
Mass (Da):56,968
Last modified:December 1, 2000 - v2
Checksum:iACB5D86F9A83C02E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78L → R in AAC05213 (Ref. 1) Curated1
Sequence conflicti226Missing in AAC05213 (Ref. 1) Curated1
Sequence conflicti316D → EV in AAC05213 (Ref. 1) Curated1
Sequence conflicti440R → G in AAC05213 (Ref. 1) Curated1
Sequence conflicti463 – 464QV → RI in AAC05213 (Ref. 1) Curated2
Sequence conflicti470 – 481SRHAN…KTAGI → KSYLREDCGY in AAC05213 (Ref. 1) CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050465 mRNA Translation: AAC05213.1
CU329671 Genomic DNA Translation: CAB53722.1
X91498 Genomic DNA Translation: CAA62798.1
PIRiT39263
T43649
RefSeqiNP_595155.1, NM_001021064.2

Genome annotation databases

EnsemblFungiiSPBC106.06.1; SPBC106.06.1:pep; SPBC106.06
GeneIDi2540053
KEGGispo:SPBC106.06

Similar proteinsi

Entry informationi

Entry nameiTCPD_SCHPO
AccessioniPrimary (citable) accession number: P50999
Secondary accession number(s): O59929, Q9URV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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