Reviewed,
UniProtKB/Swiss-Prot P50998 (AMPD_SCHPO)
Last modified
September 22, 2009.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: AMP deaminase EC=3.5.4.6 Alternative name(s): Myoadenylate deaminase | ||||
| Gene names |
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| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4896 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 846 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | AMP deaminase plays a critical role in energy metabolism. |
| Catalytic activity | AMP + H2O = IMP + NH3. |
| Pathway | Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1. |
| Subunit structure | Homotetramer By similarity. |
| Sequence similarities | Belongs to the adenosine and AMP deaminases family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide metabolism |
| Molecular function | Hydrolase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cellular nitrogen compound metabolic process Inferred by curator. Source: GeneDB_SPombe purine base metabolic processInferred from electronic annotation. Source: InterPro purine ribonucleoside monophosphate biosynthetic processInferred from electronic annotation. Source: InterPro |
| Cellular component | cytosol Inferred from direct assay. Source: GeneDB_SPombe |
| Molecular function | AMP deaminase activity Inferred from direct assay. Source: GeneDB_SPombe |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 846 | 846 | AMP deaminase | PRO_0000194413 | |||||
Sites | |||||||||
| Active site | 394 | 1 | Potential | ||||||
| Active site | 603 | 1 | Potential | ||||||
| Active site | 679 | 1 | Potential | ||||||
| Active site | 680 | 1 | Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 94 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 99 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 773 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 791 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 795 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 797 | 1 | Phosphoserine Ref.3 | ||||||
Experimental info | |||||||||
| Sequence conflict | 483 – 520 | 38 | NVRWL…PLFEV → TFVGLFKYLVCMMCIRSPVL LRLLKRSSEMSLNHCSKF in CAA62797. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Rochet M., Levesque H., Gaillardin C. Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 38366 / 972. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
| [3] | "Phosphoproteome analysis of fission yeast." Wilson-Grady J.T., Villen J., Gygi S.P. J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94; SER-99; SER-773; SER-791; SER-795 AND SER-797, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| X91498 Genomic DNA. Translation: CAA62797.1. Sequence problems. CU329671 Genomic DNA. Translation: CAB53720.1. | |
| PIR | T39261. |
| RefSeq | NP_595153.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P50998. |
Genome annotation databases | |
| GeneID | 2540105. |
| GenomeReviews | Gene locus ada1 in contig CU329671_GR. |
| KEGG | spo:SPBC106.04. |
| NMPDR | fig|4896.1.peg.1019. |
Organism-specific databases | |
| GeneDB_Spombe | SPBC106.04. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-003250-MON. |
| BRENDA | 3.5.4.6. 653. |
Gene expression databases | |
| ArrayExpress | P50998. |
Family and domain databases | |
| InterPro | IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006329. AMP_deaminase. IPR016297. AMP_deaminase_met. [Graphical view] |
| Pfam | PF00962. A_deaminase. 1 hit. [Graphical view] |
| PIRSF | PIRSF001251. AMP_deaminase_met. 1 hit. |
| TIGRFAMs | TIGR01429. AMP_deaminase. 1 hit. |
| PROSITE | PS00485. A_DEAMINASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AMPD_SCHPO | ||||||||
| Accession | Primary (citable) accession number: P50998 Secondary accession number(s): Q9URV7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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