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Reviewed, UniProtKB/Swiss-Prot P50996 (ATP4A_CANFA)

Last modified October 13, 2009. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Potassium-transporting ATPase alpha chain 1
    EC=3.6.3.10
Alternative name(s):
    Proton pump
    Gastric H(+)/K(+) ATPase subunit alpha
Gene names
Name: ATP4A
OrganismCanis familiaris (Dog)
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

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Protein attributes

Sequence length1034 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for acid production in the stomach.

Catalytic activity

ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

Subunit structure

Composed of two subunits: alpha (catalytic) and beta.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 10341033Potassium-transporting ATPase alpha chain 1
PRO_0000046252

Regions

Topological domain2 – 9796Cytoplasmic Potential
Transmembrane98 – 11821 Potential
Topological domain119 – 14123Lumenal Potential
Transmembrane142 – 16221 Potential
Topological domain163 – 298136Cytoplasmic Potential
Transmembrane299 – 31820 Potential
Topological domain319 – 33012Lumenal Potential
Transmembrane331 – 34818 Potential
Topological domain349 – 782434Cytoplasmic Potential
Transmembrane783 – 80220 Potential
Topological domain803 – 81210Lumenal Potential
Transmembrane813 – 83321 Potential
Topological domain834 – 85320Cytoplasmic Potential
Transmembrane854 – 87623 Potential
Topological domain877 – 92852Lumenal Potential
Transmembrane929 – 94820 Potential
Topological domain949 – 96214Cytoplasmic Potential
Transmembrane963 – 98119 Potential
Topological domain982 – 99615Lumenal Potential
Transmembrane997 – 101721 Potential
Topological domain1018 – 103417Cytoplasmic Potential

Sites

Active site38614-aspartylphosphate intermediate By similarity
Metal binding7271Magnesium By similarity
Metal binding7311Magnesium By similarity

Amino acid modifications

Modified residue9531Phosphoserine; by PKA By similarity

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Sequences

Sequence LengthMass (Da)Tools
P50996-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 452AE1185C0D62E8

FASTA1,034114,106
        10         20         30         40         50         60 
MGKAENYEMY SVELGPGPGG DMAAKMSKKK AGKGGGKKKE KLENMKKEME INDHQLSVAE 

        70         80         90        100        110        120 
LEQKYQTSAT KGLSASLAAD LLLRDGPNAL RPPRGTPEYV KFARQLAGGL QCLMWVAAAI 

       130        140        150        160        170        180 
CLIAFAIQAS EGDLTTDDNL YLALALIAVV VVTGCFGYYQ EFKSTNIIAS FKNLVPQQAT 

       190        200        210        220        230        240 
VIRDGDKFQI NADQLVVGDL VEMKGGDRVP ADIRILQAQG CKVDNSSLTG ESEPQTRSPE 

       250        260        270        280        290        300 
CTHESPLETR NIALFSTMCL EGTAQGLVVN TGDRTIIGRI ASLASGVENE KTPIAIEIEH 

       310        320        330        340        350        360 
FVDIIAGLAI LFGATFFVVA MCIGYTFLRA MVFFMAIVVA YVPEGLLATV TVCLSLTAKR 

       370        380        390        400        410        420 
LASKNCVVKN LEAVETLGSK SVICSDKTGT LTQNSMTVSN LWFDNHIHTA DTTEDQSGQK 

       430        440        450        460        470        480 
FDQSSETWRA LCRVLTLCNR AAFKSGQDAV PVPKRIVIGD ASETALLKFS ELTLGNAMGY 

       490        500        510        520        530        540 
RERFPKVCEI PFNSTNKFQL SIHTLEDPRD PRHVLVMKGA PERVLERCSS ILIKGQELPL 

       550        560        570        580        590        600 
DEQWREAFQT AYLSLGGLGE RVLGFCQLYL SEKDYPPGYA FDVEAMNFPT SGLCFAGLVS 

       610        620        630        640        650        660 
MIDPPRATVP DAVLKCRTAG IRVIMVTGDH PITAKAIAAS VGIISEGSET VEDIAARLRV 

       670        680        690        700        710        720 
PVDQVNRKDA RACVINGMQL KDMDPSELVE ALRTHPEMVF ARTSPQQKLV IVESCQRLGA 

       730        740        750        760        770        780 
IVAVTGDGVN DSPALKKADI GVAMGIAGSD AAKNAADMIL LDDNFASIVT GVEQGRLIFD 

       790        800        810        820        830        840 
NLKKSIAYTL TKNIPELTPY LIYITVSVPL PLGCITILFI ELCTDIFPSV SLAYEKAESD 

       850        860        870        880        890        900 
IMHLRPRNPK RDRLVNEPLA AYSYFQIGAI QSFAGFTDYF TAMAQEGWFP LLCVGLRPYW 

       910        920        930        940        950        960 
ENHHLQDLQD SYGQEWTFGQ RLYQQYTCYT VFFISIEMCQ IADVLIRKTR RLSAFQQGFF 

       970        980        990       1000       1010       1020 
RNRILVIAIV FQVCIGCFLC YCPGMPNIFN FMPIRYQWWL VPMPFGLLIF VYDEIRKLGV 

      1030 
RCCPGSWWDQ ELYY

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References

[1]"Molecular cloning and structural analysis of canine gastric H+,K(+)-ATPase."
Song I., Mortell M.P., Gantz I., Brown D.R., Yamada T.
Biochem. Biophys. Res. Commun. 196:1240-1247(1993) [PubMed: 8250881] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Stomach.

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Cross-references

Sequence databases

L11568 mRNA. Translation: AAA30848.1.
PIRJN0903.
RefSeqNP_001003342.1.
UniGeneCfa.3889

3D structure databases

HSSPHSSP built from PDB template 1IWC based on UniProtKB P19156.
ModBaseSearch...

Protein-protein interaction databases

STRINGP50996.

Genome annotation databases

EnsemblENSCAFT00000011158; ENSCAFP00000010336; ENSCAFG00000006951; Canis familiaris. [Genome view]
GeneID431686.
KEGGcfa:431686.

Organism-specific databases

CTD431686.

Phylogenomic databases

HOVERGENP50996.

Enzyme and pathway databases

BRENDA3.6.3.10. 463.

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-reg.
IPR005775. ATPase_P-typ_cation-ex_asu_euk.
IPR006069. ATPase_P-typ_cation-exchng_asu.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR015127. ATPase_P-typ_H/K-transp_N.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR005834. Dehalogen-like_hydro.
[Graphical view]
PANTHERPTHR11939. ATPase_P. 1 hit.
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF09040. H-K_ATPase_N. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00121. NAKATPASE.
TIGRFAMsTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 4 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameATP4A_CANFA
AccessionPrimary (citable) accession number: P50996
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: October 13, 2009
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents