Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Annexin A11

Gene

ANXA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.By similarity1 Publication

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium-dependent protein binding Source: UniProtKB
  • calcium ion binding Source: Ensembl
  • MHC class II protein complex binding Source: UniProtKB
  • phosphatidylethanolamine binding Source: Ensembl
  • poly(A) RNA binding Source: UniProtKB
  • S100 protein binding Source: UniProtKB

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • phagocytosis Source: UniProtKB
  • response to calcium ion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122359-MONOMER.

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A11
Alternative name(s):
56 kDa autoantigen
Annexin XI
Annexin-11
Calcyclin-associated annexin 50
Short name:
CAP-50
Gene namesi
Name:ANXA11
Synonyms:ANX11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:535. ANXA11.

Subcellular locationi

  • Cytoplasm
  • Melanosome
  • Nucleus envelope
  • Nucleusnucleoplasm
  • Cytoplasmcytoskeletonspindle

  • Note: Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent.By similarity

GO - Cellular componenti

  • azurophil granule Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • melanosome Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • midbody Source: UniProtKB
  • nuclear envelope Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • phagocytic vesicle Source: UniProtKB
  • specific granule Source: UniProtKB
  • spindle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi311.
OpenTargetsiENSG00000122359.
PharmGKBiPA24825.

Polymorphism and mutation databases

BioMutaiANXA11.
DMDMi1703322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675101 – 505Annexin A11Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248N6-acetyllysineCombined sources1
Modified residuei255N6-acetyllysineCombined sources1
Modified residuei479N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP50995.
PaxDbiP50995.
PeptideAtlasiP50995.
PRIDEiP50995.

2D gel databases

REPRODUCTION-2DPAGEP50995.

PTM databases

iPTMnetiP50995.
PhosphoSitePlusiP50995.
SwissPalmiP50995.

Expressioni

Gene expression databases

BgeeiENSG00000122359.
CleanExiHS_ANXA11.
ExpressionAtlasiP50995. baseline and differential.
GenevisibleiP50995. HS.

Organism-specific databases

HPAiCAB004851.
HPA027545.

Interactioni

Subunit structurei

Interacts with S100A6 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis.By similarity3 Publications

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • MHC class II protein complex binding Source: UniProtKB
  • S100 protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi106808. 49 interactors.
IntActiP50995. 16 interactors.
MINTiMINT-4998941.
STRINGi9606.ENSP00000265447.

Structurei

3D structure databases

ProteinModelPortaliP50995.
SMRiP50995.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati209 – 269Annexin 1Add BLAST61
Repeati281 – 341Annexin 2Add BLAST61
Repeati365 – 425Annexin 3Add BLAST61
Repeati440 – 500Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOVERGENiHBG061815.
InParanoidiP50995.
KOiK17095.
OMAiDIRMEYK.
OrthoDBiEOG091G0H6H.
PhylomeDBiP50995.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR008157. AnnexinXI.
[Graphical view]
PANTHERiPTHR10502:SF29. PTHR10502:SF29. 3 hits.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01810. ANNEXINXI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P50995-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYPGYPPPP GGYPPAAPGG GPWGGAAYPP PPSMPPIGLD NVATYAGQFN
60 70 80 90 100
QDYLSGMAAN MSGTFGGANM PNLYPGAPGA GYPPVPPGGF GQPPSAQQPV
110 120 130 140 150
PPYGMYPPPG GNPPSRMPSY PPYPGAPVPG QPMPPPGQQP PGAYPGQPPV
160 170 180 190 200
TYPGQPPVPL PGQQQPVPSY PGYPGSGTVT PAVPPTQFGS RGTITDAPGF
210 220 230 240 250
DPLRDAEVLR KAMKGFGTDE QAIIDCLGSR SNKQRQQILL SFKTAYGKDL
260 270 280 290 300
IKDLKSELSG NFEKTILALM KTPVLFDIYE IKEAIKGVGT DEACLIEILA
310 320 330 340 350
SRSNEHIREL NRAYKAEFKK TLEEAIRSDT SGHFQRLLIS LSQGNRDEST
360 370 380 390 400
NVDMSLAQRD AQELYAAGEN RLGTDESKFN AVLCSRSRAH LVAVFNEYQR
410 420 430 440 450
MTGRDIEKSI CREMSGDLEE GMLAVVKCLK NTPAFFAERL NKAMRGAGTK
460 470 480 490 500
DRTLIRIMVS RSETDLLDIR SEYKRMYGKS LYHDISGDTS GDYRKILLKI

CGGND
Length:505
Mass (Da):54,390
Last modified:October 1, 1996 - v1
Checksum:i4ADCAC8F270BFEE4
GO
Isoform 2 (identifier: P50995-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Note: No experimental confirmation available.
Show »
Length:472
Mass (Da):51,242
Checksum:i477704C7C6863AE0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048259191R → Q.Corresponds to variant rs2229554dbSNPEnsembl.1
Natural variantiVAR_012006230R → C.Corresponds to variant rs1049550dbSNPEnsembl.1
Natural variantiVAR_012007457I → V.Corresponds to variant rs1802932dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0545531 – 33Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19605 mRNA. Translation: AAA19734.1.
AJ278463 mRNA. Translation: CAB94995.1.
AJ278464 mRNA. Translation: CAB94996.1.
AJ278465 mRNA. Translation: CAB94997.1.
AK301047 mRNA. Translation: BAG62659.1.
AL356095 Genomic DNA. No translation available.
AL513174 Genomic DNA. No translation available.
BC007564 mRNA. Translation: AAH07564.1.
CCDSiCCDS60576.1. [P50995-2]
CCDS7364.1. [P50995-1]
PIRiA53152.
RefSeqiNP_001148.1. NM_001157.2. [P50995-1]
NP_001265336.1. NM_001278407.1. [P50995-1]
NP_001265337.1. NM_001278408.1. [P50995-1]
NP_001265338.1. NM_001278409.1. [P50995-2]
NP_665875.1. NM_145868.1. [P50995-1]
NP_665876.1. NM_145869.1. [P50995-1]
XP_011538038.1. XM_011539736.2. [P50995-1]
UniGeneiHs.530291.

Genome annotation databases

EnsembliENST00000265447; ENSP00000265447; ENSG00000122359. [P50995-2]
ENST00000372231; ENSP00000361305; ENSG00000122359. [P50995-1]
ENST00000422982; ENSP00000404412; ENSG00000122359. [P50995-1]
ENST00000438331; ENSP00000398610; ENSG00000122359. [P50995-1]
GeneIDi311.
KEGGihsa:311.
UCSCiuc057umu.1. human. [P50995-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19605 mRNA. Translation: AAA19734.1.
AJ278463 mRNA. Translation: CAB94995.1.
AJ278464 mRNA. Translation: CAB94996.1.
AJ278465 mRNA. Translation: CAB94997.1.
AK301047 mRNA. Translation: BAG62659.1.
AL356095 Genomic DNA. No translation available.
AL513174 Genomic DNA. No translation available.
BC007564 mRNA. Translation: AAH07564.1.
CCDSiCCDS60576.1. [P50995-2]
CCDS7364.1. [P50995-1]
PIRiA53152.
RefSeqiNP_001148.1. NM_001157.2. [P50995-1]
NP_001265336.1. NM_001278407.1. [P50995-1]
NP_001265337.1. NM_001278408.1. [P50995-1]
NP_001265338.1. NM_001278409.1. [P50995-2]
NP_665875.1. NM_145868.1. [P50995-1]
NP_665876.1. NM_145869.1. [P50995-1]
XP_011538038.1. XM_011539736.2. [P50995-1]
UniGeneiHs.530291.

3D structure databases

ProteinModelPortaliP50995.
SMRiP50995.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106808. 49 interactors.
IntActiP50995. 16 interactors.
MINTiMINT-4998941.
STRINGi9606.ENSP00000265447.

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

PTM databases

iPTMnetiP50995.
PhosphoSitePlusiP50995.
SwissPalmiP50995.

Polymorphism and mutation databases

BioMutaiANXA11.
DMDMi1703322.

2D gel databases

REPRODUCTION-2DPAGEP50995.

Proteomic databases

EPDiP50995.
PaxDbiP50995.
PeptideAtlasiP50995.
PRIDEiP50995.

Protocols and materials databases

DNASUi311.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265447; ENSP00000265447; ENSG00000122359. [P50995-2]
ENST00000372231; ENSP00000361305; ENSG00000122359. [P50995-1]
ENST00000422982; ENSP00000404412; ENSG00000122359. [P50995-1]
ENST00000438331; ENSP00000398610; ENSG00000122359. [P50995-1]
GeneIDi311.
KEGGihsa:311.
UCSCiuc057umu.1. human. [P50995-1]

Organism-specific databases

CTDi311.
DisGeNETi311.
GeneCardsiANXA11.
HGNCiHGNC:535. ANXA11.
HPAiCAB004851.
HPA027545.
MIMi602572. gene.
neXtProtiNX_P50995.
OpenTargetsiENSG00000122359.
PharmGKBiPA24825.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOVERGENiHBG061815.
InParanoidiP50995.
KOiK17095.
OMAiDIRMEYK.
OrthoDBiEOG091G0H6H.
PhylomeDBiP50995.
TreeFamiTF105452.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122359-MONOMER.

Miscellaneous databases

ChiTaRSiANXA11. human.
GeneWikiiANXA11.
GenomeRNAii311.
PROiP50995.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122359.
CleanExiHS_ANXA11.
ExpressionAtlasiP50995. baseline and differential.
GenevisibleiP50995. HS.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR008157. AnnexinXI.
[Graphical view]
PANTHERiPTHR10502:SF29. PTHR10502:SF29. 3 hits.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01810. ANNEXINXI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANX11_HUMAN
AccessioniPrimary (citable) accession number: P50995
Secondary accession number(s): B4DVE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.