P50995 (ANX11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Annexin A11

Alternative name(s):
56 kDa autoantigen
Annexin XI
Annexin-11
Calcyclin-associated annexin 50
Short name=CAP-50

Gene names

Name:	ANXA11
Synonyms:	ANX11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds specifically to calcyclin in a calcium-dependent manner By similarity. Required for midbody formation and completion of the terminal phase of cytokinesis. Ref.7
Subunit structure	Interacts with S100A6 By similarity. Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis. Ref.4 Ref.7 Ref.9
Subcellular location	Cytoplasm. Melanosome. Nucleus envelope. Nucleus › nucleoplasm. Cytoplasm › cytoskeleton › spindle. Note: Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus By similarity. Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent. Ref.5 Ref.6 Ref.7 Ref.8
Domain	A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence similarities	Belongs to the annexin family. Contains 4 annexin repeats.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cytoplasm Cytoskeleton Nucleus
Coding sequence diversity	Polymorphism
Domain	Annexin Repeat
Ligand	Calcium Calcium/phospholipid-binding
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis, completion of separation Inferred from mutant phenotype Ref.7. Source: UniProtKB phagocytosis Inferred from expression pattern PubMed 9188810. Source: UniProtKB response to calcium ion Inferred from direct assay Ref.5PubMed 9188810. Source: UniProtKB
Cellular_component	azurophil granule Inferred from direct assay PubMed 9188810. Source: UniProtKB melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell midbody Inferred from direct assay Ref.7. Source: UniProtKB nuclear envelope Inferred from direct assay Ref.5Ref.7. Source: UniProtKB nucleoplasm Inferred from direct assay Ref.5Ref.7Ref.1. Source: UniProtKB phagocytic vesicle Inferred from direct assay PubMed 9188810. Source: UniProtKB specific granule Inferred from direct assay PubMed 9188810. Source: UniProtKB spindle Inferred from direct assay Ref.6Ref.7. Source: UniProtKB
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: Compara calcium-dependent phospholipid binding Inferred from electronic annotation. Source: UniProtKB-KW phosphatidylethanolamine binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	Annexin A11		PRO_0000067510
Regions
	Repeat	209 – 269	61	Annexin 1
	Repeat	281 – 341	61	Annexin 2
	Repeat	365 – 425	61	Annexin 3
	Repeat	440 – 500	61	Annexin 4
Amino acid modifications
	Modified residue	248	1	N6-acetyllysine Ref.10
	Modified residue	255	1	N6-acetyllysine Ref.10
	Modified residue	479	1	N6-acetyllysine Ref.10
Natural variations
	Natural variant	191	1	R → Q. Corresponds to variant rs2229554 [ dbSNP | Ensembl ].		VAR_048259
	Natural variant	230	1	R → C. Corresponds to variant rs1049550 [ dbSNP | Ensembl ].		VAR_012006
	Natural variant	457	1	I → V. Corresponds to variant rs1802932 [ dbSNP | Ensembl ].		VAR_012007

Sequences

	Sequence		Length	Mass (Da)
	P50995 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 4ADCAC8F270BFEE4	FASTA	505	54,390
	10 20 30 40 50 60 MSYPGYPPPP GGYPPAAPGG GPWGGAAYPP PPSMPPIGLD NVATYAGQFN QDYLSGMAAN 70 80 90 100 110 120 MSGTFGGANM PNLYPGAPGA GYPPVPPGGF GQPPSAQQPV PPYGMYPPPG GNPPSRMPSY 130 140 150 160 170 180 PPYPGAPVPG QPMPPPGQQP PGAYPGQPPV TYPGQPPVPL PGQQQPVPSY PGYPGSGTVT 190 200 210 220 230 240 PAVPPTQFGS RGTITDAPGF DPLRDAEVLR KAMKGFGTDE QAIIDCLGSR SNKQRQQILL 250 260 270 280 290 300 SFKTAYGKDL IKDLKSELSG NFEKTILALM KTPVLFDIYE IKEAIKGVGT DEACLIEILA 310 320 330 340 350 360 SRSNEHIREL NRAYKAEFKK TLEEAIRSDT SGHFQRLLIS LSQGNRDEST NVDMSLAQRD 370 380 390 400 410 420 AQELYAAGEN RLGTDESKFN AVLCSRSRAH LVAVFNEYQR MTGRDIEKSI CREMSGDLEE 430 440 450 460 470 480 GMLAVVKCLK NTPAFFAERL NKAMRGAGTK DRTLIRIMVS RSETDLLDIR SEYKRMYGKS 490 500 LYHDISGDTS GDYRKILLKI CGGND

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The 56K autoantigen is identical to human annexin XI." Misaki Y., Pruijn G.J.M., van der Kemp A.W., van Venrooij W.J. J. Biol. Chem. 269:4240-4246(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Teratocarcinoma.
[2]	"Annexin A11 (ANXA11) gene structure as the progenitor of paralogous annexins and source of orthologous cDNA isoforms." Bances P., Fernandez M.R., Rodriguez-Garcia M.I., Morgan R.O., Fernandez M.-P. Genomics 69:95-103(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph.
[4]	"ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner." Satoh H., Shibata H., Nakano Y., Kitaura Y., Maki M. Biochem. Biophys. Res. Commun. 291:1166-1172(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PDCD6.
[5]	"Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope." Tomas A., Moss S.E. J. Biol. Chem. 278:20210-20216(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[6]	"Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display." Farnaes L., Ditzel H.J. J. Biol. Chem. 278:33120-33126(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[7]	"Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis." Tomas A., Futter C., Moss S.E. J. Cell Biol. 165:813-822(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH KIF23.
[8]	"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes." Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F. J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Melanoma.
[9]	"Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants." Shibata H., Suzuki H., Kakiuchi T., Inuzuka T., Yoshida H., Mizuno T., Maki M. J. Biol. Chem. 283:9623-9632(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PDCD6.
[10]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-248; LYS-255 AND LYS-479, MASS SPECTROMETRY.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L19605 mRNA. Translation: AAA19734.1. AJ278463 mRNA. Translation: CAB94995.1. AJ278464 mRNA. Translation: CAB94996.1. AJ278465 mRNA. Translation: CAB94997.1. BC007564 mRNA. Translation: AAH07564.1.
IPI	IPI00414320.
PIR	A53152.
RefSeq	NP_001148.1. NM_001157.2. NP_665875.1. NM_145868.1. NP_665876.1. NM_145869.1.
UniGene	Hs.530291.
3D structure databases
ProteinModelPortal	P50995.
ModBase	Search...
Protein-protein interaction databases
IntAct	P50995. 7 interactions.
STRING	9606.ENSP00000265447.
PTM databases
PhosphoSite	P50995.
Polymorphism databases
DMDM	1703322.
2D gel databases
REPRODUCTION-2DPAGE	P50995.
Proteomic databases
PaxDb	P50995.
PeptideAtlas	P50995.
PRIDE	P50995.
Protocols and materials databases
DNASU	311.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265447; ENSP00000265447; ENSG00000122359. ENST00000360615; ENSP00000353827; ENSG00000122359. ENST00000372231; ENSP00000361305; ENSG00000122359. ENST00000372234; ENSP00000361308; ENSG00000122359. ENST00000422982; ENSP00000404412; ENSG00000122359. ENST00000438331; ENSP00000398610; ENSG00000122359. ENST00000535999; ENSP00000441748; ENSG00000122359.
GeneID	311.
KEGG	hsa:311.
UCSC	uc001kbq.1. human.
Organism-specific databases
CTD	311.
GeneCards	GC10M081904.
HGNC	HGNC:535. ANXA11.
HPA	CAB004851. HPA027545.
MIM	602572. gene.
neXtProt	NX_P50995.
PharmGKB	PA24825.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG267770.
HOVERGEN	HBG061815.
InParanoid	P50995.
OMA	NMYPGAP.
OrthoDB	EOG4Z0B60.
Gene expression databases
ArrayExpress	P50995.
Bgee	P50995.
CleanEx	HS_ANXA11.
Genevestigator	P50995.
GermOnline	ENSG00000122359. Homo sapiens.
Family and domain databases
Gene3D	1.10.220.10. 4 hits.
InterPro	IPR001464. Annexin. IPR018502. Annexin_repeat. IPR018252. Annexin_repeat_CS. IPR008157. AnnexinXI. [Graphical view]
PANTHER	PTHR10502. PTHR10502. 1 hit. PTHR10502:SF29. PTHR10502:SF29. 1 hit.
Pfam	PF00191. Annexin. 4 hits. [Graphical view]
PRINTS	PR00196. ANNEXIN. PR01810. ANNEXINXI.
SMART	SM00335. ANX. 4 hits. [Graphical view]
SUPFAM	SSF47874. Annexin. 1 hit.
PROSITE	PS00223. ANNEXIN. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ANXA11. human.
GenomeRNAi	311.
NextBio	1259.
SOURCE	Search...

Entry information

Entry name

ANX11_HUMAN

Accession

Primary (citable) accession number: P50995

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.