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Protein

Sodium/potassium-transporting ATPase subunit alpha-2

Gene

ATP1A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3744-aspartylphosphate intermediateBy similarity1
Metal bindingi714MagnesiumBy similarity1
Metal bindingi718MagnesiumBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • chaperone binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
  • sodium:potassium-exchanging ATPase activity Source: UniProtKB
  • steroid hormone binding Source: BHF-UCL

GO - Biological processi

  • adult locomotory behavior Source: Ensembl
  • ATP hydrolysis coupled proton transport Source: GO_Central
  • ATP metabolic process Source: BHF-UCL
  • cardiac muscle contraction Source: BHF-UCL
  • cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
  • cellular potassium ion homeostasis Source: BHF-UCL
  • cellular response to mechanical stimulus Source: Ensembl
  • cellular response to steroid hormone stimulus Source: BHF-UCL
  • cellular sodium ion homeostasis Source: BHF-UCL
  • ion transmembrane transport Source: Reactome
  • locomotion Source: Ensembl
  • membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
  • membrane repolarization Source: BHF-UCL
  • negative regulation of calcium:sodium antiporter activity Source: BHF-UCL
  • negative regulation of calcium ion transmembrane transport Source: BHF-UCL
  • negative regulation of cytosolic calcium ion concentration Source: Ensembl
  • negative regulation of heart contraction Source: Ensembl
  • negative regulation of striated muscle contraction Source: Ensembl
  • neurotransmitter uptake Source: Ensembl
  • potassium ion import Source: BHF-UCL
  • potassium ion import across plasma membrane Source: BHF-UCL
  • potassium ion transport Source: UniProtKB
  • regulation of blood pressure Source: Ensembl
  • regulation of cardiac conduction Source: Reactome
  • regulation of cardiac muscle cell contraction Source: Ensembl
  • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
  • regulation of glutamate uptake involved in transmission of nerve impulse Source: BHF-UCL
  • regulation of respiratory gaseous exchange by neurological system process Source: Ensembl
  • regulation of smooth muscle contraction Source: Ensembl
  • regulation of striated muscle contraction Source: UniProtKB
  • regulation of synaptic transmission, glutamatergic Source: BHF-UCL
  • regulation of the force of heart contraction Source: Ensembl
  • regulation of vasoconstriction Source: Ensembl
  • relaxation of cardiac muscle Source: BHF-UCL
  • response to glycoside Source: BHF-UCL
  • response to nicotine Source: Ensembl
  • sodium ion export from cell Source: BHF-UCL
  • sodium ion transport Source: UniProtKB
  • visual learning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Enzyme and pathway databases

BioCyciZFISH:HS00391-MONOMER.
ReactomeiR-HSA-5578775. Ion homeostasis.
R-HSA-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.1.1. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-2 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-2 subunit
Alternative name(s):
Sodium pump subunit alpha-2
Gene namesi
Name:ATP1A2
Synonyms:KIAA0778
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:800. ATP1A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini6 – 85CytoplasmicSequence analysisAdd BLAST80
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 129ExtracellularSequence analysisAdd BLAST23
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Topological domaini151 – 286CytoplasmicSequence analysisAdd BLAST136
Transmembranei287 – 306HelicalSequence analysisAdd BLAST20
Topological domaini307 – 318ExtracellularSequence analysisAdd BLAST12
Transmembranei319 – 336HelicalSequence analysisAdd BLAST18
Topological domaini337 – 769CytoplasmicSequence analysisAdd BLAST433
Transmembranei770 – 789HelicalSequence analysisAdd BLAST20
Topological domaini790 – 799ExtracellularSequence analysis10
Transmembranei800 – 820HelicalSequence analysisAdd BLAST21
Topological domaini821 – 840CytoplasmicSequence analysisAdd BLAST20
Transmembranei841 – 863HelicalSequence analysisAdd BLAST23
Topological domaini864 – 915ExtracellularSequence analysisAdd BLAST52
Transmembranei916 – 935HelicalSequence analysisAdd BLAST20
Topological domaini936 – 948CytoplasmicSequence analysisAdd BLAST13
Transmembranei949 – 967HelicalSequence analysisAdd BLAST19
Topological domaini968 – 982ExtracellularSequence analysisAdd BLAST15
Transmembranei983 – 1003HelicalSequence analysisAdd BLAST21
Topological domaini1004 – 1020CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

  • caveola Source: Ensembl
  • cytoplasm Source: UniProtKB
  • dendritic spine Source: Ensembl
  • endosome Source: Ensembl
  • extracellular vesicle Source: UniProtKB
  • intercalated disc Source: Ensembl
  • intracellular membrane-bounded organelle Source: GO_Central
  • membrane Source: BHF-UCL
  • myelin sheath Source: Ensembl
  • plasma membrane Source: UniProtKB
  • sodium:potassium-exchanging ATPase complex Source: UniProtKB
  • T-tubule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Migraine, familial hemiplegic, 2 (FHM2)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA subtype of migraine with aura associated with hemiparesis in some families. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. Migraine with aura is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking.
See also OMIM:602481
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019935689R → Q in FHM2. 1 PublicationCorresponds to variant rs28933401dbSNPEnsembl.1
Natural variantiVAR_065685715G → R in FHM2; de novo mutation in a sporadic case. 1 Publication1
Natural variantiVAR_019936731M → T in FHM2. 1 PublicationCorresponds to variant rs28933400dbSNPEnsembl.1
Natural variantiVAR_019937764L → P in FHM2; loss of function. 1 PublicationCorresponds to variant rs28933398dbSNPEnsembl.1
Natural variantiVAR_069991874G → S in FHM2; some patients exhibit a clinical overlap between migraine and epilepsy. 1 Publication1
Natural variantiVAR_019938887W → R in FHM2; loss of function. 1 PublicationCorresponds to variant rs28933399dbSNPEnsembl.1
Natural variantiVAR_0699921007R → W in FHM2; some patients exhibit a clinical overlap between migraine and epilepsy. 1 Publication1
Alternating hemiplegia of childhood 1 (AHC1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare syndrome of episodic hemi- or quadriplegia lasting minutes to days. Most cases are accompanied by dystonic posturing, choreoathetoid movements, nystagmus, other ocular motor abnormalities, autonomic disturbances, and progressive cognitive impairment. It is typically distinguished from familial hemiplegic migraine by infantile onset and high prevalence of associated neurological deficits that become increasingly obvious with age.
See also OMIM:104290
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019934378T → N in AHC1. 1 PublicationCorresponds to variant rs28934002dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi477.
MalaCardsiATP1A2.
MIMi104290. phenotype.
602481. phenotype.
OpenTargetsiENSG00000018625.
Orphaneti2131. Alternating hemiplegia of childhood.
569. Familial or sporadic hemiplegic migraine.
PharmGKBiPA30796.

Chemistry databases

ChEMBLiCHEMBL2095186.

Polymorphism and mutation databases

BioMutaiATP1A2.
DMDMi1703467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
PropeptideiPRO_00000025032 – 5By similarity4
ChainiPRO_00000025046 – 1020Sodium/potassium-transporting ATPase subunit alpha-2Add BLAST1015

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Modified residuei45PhosphoserineBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei273PhosphoserineBy similarity1
Modified residuei439PhosphoserineBy similarity1
Modified residuei450PhosphoserineBy similarity1
Modified residuei496PhosphoserineBy similarity1
Modified residuei559PhosphoserineBy similarity1
Modified residuei570PhosphothreonineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei672PhosphoserineBy similarity1
Modified residuei826PhosphoserineBy similarity1
Modified residuei940Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP50993.
MaxQBiP50993.
PaxDbiP50993.
PeptideAtlasiP50993.
PRIDEiP50993.

PTM databases

iPTMnetiP50993.
PhosphoSitePlusiP50993.
SwissPalmiP50993.

Expressioni

Gene expression databases

BgeeiENSG00000018625.
CleanExiHS_ATP1A2.
ExpressionAtlasiP50993. baseline and differential.
GenevisibleiP50993. HS.

Organism-specific databases

HPAiCAB022230.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

GO - Molecular functioni

  • chaperone binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi106967. 19 interactors.
IntActiP50993. 2 interactors.
STRINGi9606.ENSP00000354490.

Structurei

3D structure databases

ProteinModelPortaliP50993.
SMRiP50993.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni80 – 82Interaction with phosphoinositide-3 kinaseBy similarity3

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00850000132256.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP50993.
KOiK01539.
OMAiMREAFNN.
OrthoDBiEOG091G01BB.
PhylomeDBiP50993.
TreeFamiTF312838.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRGAGREYS PAATTAENGG GKKKQKEKEL DELKKEVAMD DHKLSLDELG
60 70 80 90 100
RKYQVDLSKG LTNQRAQDVL ARDGPNALTP PPTTPEWVKF CRQLFGGFSI
110 120 130 140 150
LLWIGAILCF LAYGIQAAME DEPSNDNLYL GVVLAAVVIV TGCFSYYQEA
160 170 180 190 200
KSSKIMDSFK NMVPQQALVI REGEKMQINA EEVVVGDLVE VKGGDRVPAD
210 220 230 240 250
LRIISSHGCK VDNSSLTGES EPQTRSPEFT HENPLETRNI CFFSTNCVEG
260 270 280 290 300
TARGIVIATG DRTVMGRIAT LASGLEVGRT PIAMEIEHFI QLITGVAVFL
310 320 330 340 350
GVSFFVLSLI LGYSWLEAVI FLIGIIVANV PEGLLATVTV CLTLTAKRMA
360 370 380 390 400
RKNCLVKNLE AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIHEADT
410 420 430 440 450
TEDQSGATFD KRSPTWTALS RIAGLCNRAV FKAGQENISV SKRDTAGDAS
460 470 480 490 500
ESALLKCIEL SCGSVRKMRD RNPKVAEIPF NSTNKYQLSI HEREDSPQSH
510 520 530 540 550
VLVMKGAPER ILDRCSTILV QGKEIPLDKE MQDAFQNAYM ELGGLGERVL
560 570 580 590 600
GFCQLNLPSG KFPRGFKFDT DELNFPTEKL CFVGLMSMID PPRAAVPDAV
610 620 630 640 650
GKCRSAGIKV IMVTGDHPIT AKAIAKGVGI ISEGNETVED IAARLNIPMS
660 670 680 690 700
QVNPREAKAC VVHGSDLKDM TSEQLDEILK NHTEIVFART SPQQKLIIVE
710 720 730 740 750
GCQRQGAIVA VTGDGVNDSP ALKKADIGIA MGISGSDVSK QAADMILLDD
760 770 780 790 800
NFASIVTGVE EGRLIFDNLK KSIAYTLTSN IPEITPFLLF IIANIPLPLG
810 820 830 840 850
TVTILCIDLG TDMVPAISLA YEAAESDIMK RQPRNSQTDK LVNERLISMA
860 870 880 890 900
YGQIGMIQAL GGFFTYFVIL AENGFLPSRL LGIRLDWDDR TMNDLEDSYG
910 920 930 940 950
QEWTYEQRKV VEFTCHTAFF ASIVVVQWAD LIICKTRRNS VFQQGMKNKI
960 970 980 990 1000
LIFGLLEETA LAAFLSYCPG MGVALRMYPL KVTWWFCAFP YSLLIFIYDE
1010 1020
VRKLILRRYP GGWVEKETYY
Length:1,020
Mass (Da):112,265
Last modified:October 1, 1996 - v1
Checksum:iAFBD8EA94FFB4FC3
GO

Sequence cautioni

The sequence BAA34498 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019934378T → N in AHC1. 1 PublicationCorresponds to variant rs28934002dbSNPEnsembl.1
Natural variantiVAR_019935689R → Q in FHM2. 1 PublicationCorresponds to variant rs28933401dbSNPEnsembl.1
Natural variantiVAR_065685715G → R in FHM2; de novo mutation in a sporadic case. 1 Publication1
Natural variantiVAR_019936731M → T in FHM2. 1 PublicationCorresponds to variant rs28933400dbSNPEnsembl.1
Natural variantiVAR_019937764L → P in FHM2; loss of function. 1 PublicationCorresponds to variant rs28933398dbSNPEnsembl.1
Natural variantiVAR_069991874G → S in FHM2; some patients exhibit a clinical overlap between migraine and epilepsy. 1 Publication1
Natural variantiVAR_019938887W → R in FHM2; loss of function. 1 PublicationCorresponds to variant rs28933399dbSNPEnsembl.1
Natural variantiVAR_0699921007R → W in FHM2; some patients exhibit a clinical overlap between migraine and epilepsy. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05096 Genomic DNA. Translation: AAA51797.1.
AB018321 mRNA. Translation: BAA34498.2. Different initiation.
AL121987 Genomic DNA. Translation: CAI15271.1.
CH471121 Genomic DNA. Translation: EAW52740.1.
CH471121 Genomic DNA. Translation: EAW52741.1.
BC052271 mRNA. Translation: AAH52271.2.
M16795 mRNA. Translation: AAA51799.1.
M27578, M27571, M27576 Genomic DNA. Translation: AAA35575.1.
Y07494 mRNA. Translation: CAA68793.1. Sequence problems.
CCDSiCCDS1196.1.
PIRiA34474.
RefSeqiNP_000693.1. NM_000702.3.
UniGeneiHs.34114.

Genome annotation databases

EnsembliENST00000361216; ENSP00000354490; ENSG00000018625.
GeneIDi477.
KEGGihsa:477.
UCSCiuc001fvc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05096 Genomic DNA. Translation: AAA51797.1.
AB018321 mRNA. Translation: BAA34498.2. Different initiation.
AL121987 Genomic DNA. Translation: CAI15271.1.
CH471121 Genomic DNA. Translation: EAW52740.1.
CH471121 Genomic DNA. Translation: EAW52741.1.
BC052271 mRNA. Translation: AAH52271.2.
M16795 mRNA. Translation: AAA51799.1.
M27578, M27571, M27576 Genomic DNA. Translation: AAA35575.1.
Y07494 mRNA. Translation: CAA68793.1. Sequence problems.
CCDSiCCDS1196.1.
PIRiA34474.
RefSeqiNP_000693.1. NM_000702.3.
UniGeneiHs.34114.

3D structure databases

ProteinModelPortaliP50993.
SMRiP50993.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106967. 19 interactors.
IntActiP50993. 2 interactors.
STRINGi9606.ENSP00000354490.

Chemistry databases

ChEMBLiCHEMBL2095186.

Protein family/group databases

TCDBi3.A.3.1.1. the p-type atpase (p-atpase) superfamily.

PTM databases

iPTMnetiP50993.
PhosphoSitePlusiP50993.
SwissPalmiP50993.

Polymorphism and mutation databases

BioMutaiATP1A2.
DMDMi1703467.

Proteomic databases

EPDiP50993.
MaxQBiP50993.
PaxDbiP50993.
PeptideAtlasiP50993.
PRIDEiP50993.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361216; ENSP00000354490; ENSG00000018625.
GeneIDi477.
KEGGihsa:477.
UCSCiuc001fvc.4. human.

Organism-specific databases

CTDi477.
DisGeNETi477.
GeneCardsiATP1A2.
GeneReviewsiATP1A2.
HGNCiHGNC:800. ATP1A2.
HPAiCAB022230.
MalaCardsiATP1A2.
MIMi104290. phenotype.
182340. gene.
602481. phenotype.
neXtProtiNX_P50993.
OpenTargetsiENSG00000018625.
Orphaneti2131. Alternating hemiplegia of childhood.
569. Familial or sporadic hemiplegic migraine.
PharmGKBiPA30796.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00850000132256.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP50993.
KOiK01539.
OMAiMREAFNN.
OrthoDBiEOG091G01BB.
PhylomeDBiP50993.
TreeFamiTF312838.

Enzyme and pathway databases

BioCyciZFISH:HS00391-MONOMER.
ReactomeiR-HSA-5578775. Ion homeostasis.
R-HSA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiATP1A2. human.
GeneWikiiATP1A2.
GenomeRNAii477.
PROiP50993.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000018625.
CleanExiHS_ATP1A2.
ExpressionAtlasiP50993. baseline and differential.
GenevisibleiP50993. HS.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT1A2_HUMAN
AccessioniPrimary (citable) accession number: P50993
Secondary accession number(s): D3DVE4
, Q07059, Q5JW74, Q86UZ5, Q9UQ25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 175 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.