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Protein

Potassium-transporting ATPase subunit beta

Gene

Atp4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Hydrogen ion transport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase subunit beta
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit beta
Proton pump beta chain
Gene namesi
Name:Atp4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:88114. Atp4b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636CytoplasmicSequence analysisAdd
BLAST
Transmembranei37 – 5721Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini58 – 294237ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Potassium-transporting ATPase subunit betaPRO_0000219092Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence analysis
Disulfide bondi131 ↔ 152By similarity
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence analysis
Disulfide bondi162 ↔ 178By similarity
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence analysis
Disulfide bondi201 ↔ 266By similarity
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP50992.
PeptideAtlasiP50992.
PRIDEiP50992.

PTM databases

PhosphoSiteiP50992.

Expressioni

Gene expression databases

BgeeiP50992.
CleanExiMM_ATP4B.
ExpressionAtlasiP50992. baseline and differential.
GenevisibleiP50992. MM.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033826.

Structurei

3D structure databases

ProteinModelPortaliP50992.
SMRiP50992. Positions 32-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni194 – 294101immunoglobulin-likeBy similarityAdd
BLAST

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP50992.
KOiK01543.
OMAiKAQPHYS.
OrthoDBiEOG7M6D85.
PhylomeDBiP50992.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50992-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALQEKKSC SQRMAEFRHY CWNPDTGQML GRTPARWVWI SLYYAGFYVV
60 70 80 90 100
MTGLFALCIY VLMQTIDPYT PDYQDQLKSP GVTLRPDVYG ERGLKISYNV
110 120 130 140 150
SENSSWAGLT HTLHSFLAGY TPASQQDSIN CTSEKYFFQE SFAAPNHTKF
160 170 180 190 200
SCKFTADMLQ NCSGLADPSF GFEEGKPCFI IKMNRIVKFL PSNNTAPRVD
210 220 230 240 250
CTFQDDPQKP RKDTEPLQVE YYPPNGTFSL HYFPYYGKKA QPHYSNPLVA
260 270 280 290
AKLLNVPKNM QVSIVCKILA DHVTFNNPHD PYEGKVEFKL TIQK
Length:294
Mass (Da):33,566
Last modified:October 1, 1996 - v1
Checksum:iEAB8526C4C52431D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331T → P in BAB26635 (PubMed:16141072).Curated
Sequence conflicti214 – 2152TE → IK in BAB26654 (PubMed:16141072).Curated
Sequence conflicti218 – 2181Q → L in BAB26654 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80251
, M80247, M80248, M80249, M80250 Genomic DNA. Translation: AAA37270.1.
M64688
, M64685, M64686, M64687 Genomic DNA. Translation: AAA37269.1.
AK008180 mRNA. Translation: BAB25514.1.
AK009499 mRNA. Translation: BAB26326.1.
AK009832 mRNA. Translation: BAB26530.1. Sequence problems.
AK009994 mRNA. Translation: BAB26632.1.
AK010003 mRNA. Translation: BAB26635.1.
AK010030 mRNA. Translation: BAB26654.1.
AK010049 mRNA. Translation: BAB26665.1.
CCDSiCCDS22111.1.
PIRiA40993.
RefSeqiNP_033854.1. NM_009724.2.
UniGeneiMm.154039.

Genome annotation databases

EnsembliENSMUST00000033826; ENSMUSP00000033826; ENSMUSG00000031449.
GeneIDi11945.
KEGGimmu:11945.
UCSCiuc009kxu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80251
, M80247, M80248, M80249, M80250 Genomic DNA. Translation: AAA37270.1.
M64688
, M64685, M64686, M64687 Genomic DNA. Translation: AAA37269.1.
AK008180 mRNA. Translation: BAB25514.1.
AK009499 mRNA. Translation: BAB26326.1.
AK009832 mRNA. Translation: BAB26530.1. Sequence problems.
AK009994 mRNA. Translation: BAB26632.1.
AK010003 mRNA. Translation: BAB26635.1.
AK010030 mRNA. Translation: BAB26654.1.
AK010049 mRNA. Translation: BAB26665.1.
CCDSiCCDS22111.1.
PIRiA40993.
RefSeqiNP_033854.1. NM_009724.2.
UniGeneiMm.154039.

3D structure databases

ProteinModelPortaliP50992.
SMRiP50992. Positions 32-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033826.

PTM databases

PhosphoSiteiP50992.

Proteomic databases

PaxDbiP50992.
PeptideAtlasiP50992.
PRIDEiP50992.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033826; ENSMUSP00000033826; ENSMUSG00000031449.
GeneIDi11945.
KEGGimmu:11945.
UCSCiuc009kxu.1. mouse.

Organism-specific databases

CTDi496.
MGIiMGI:88114. Atp4b.

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP50992.
KOiK01543.
OMAiKAQPHYS.
OrthoDBiEOG7M6D85.
PhylomeDBiP50992.
TreeFamiTF314618.

Enzyme and pathway databases

ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiAtp4b. mouse.
PROiP50992.
SOURCEiSearch...

Gene expression databases

BgeeiP50992.
CleanExiMM_ATP4B.
ExpressionAtlasiP50992. baseline and differential.
GenevisibleiP50992. MM.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse gastric H,K-ATPase beta subunit. Gene structure and co-ordinate expression with the alpha subunit during ontogeny."
    Morley G.P., Callaghan J.M., Rose J.B., Toh H., Gleeson P.A., van Driel I.R.
    J. Biol. Chem. 267:1165-1174(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J.
    Tissue: Spleen.
  2. "Structural organization and transcription of the mouse gastric H+, K(+)-ATPase beta subunit gene."
    Canfield V.A., Levenson R.
    Proc. Natl. Acad. Sci. U.S.A. 88:8247-8252(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/cJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Small intestine and Tongue.

Entry informationi

Entry nameiATP4B_MOUSE
AccessioniPrimary (citable) accession number: P50992
Secondary accession number(s): Q9D6S3, Q9D6T2, Q9D6Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.