Potassium-transporting ATPase subunit beta - Mus musculus (Mouse)

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P50992 (ATP4B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 87. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Potassium-transporting ATPase subunit beta

Alternative name(s):
Gastric H(+)/K(+) ATPase subunit beta
Proton pump beta chain

Gene names

Name:

Atp4b

Organism

Mus musculus (Mouse)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Composed of two subunits: alpha (catalytic) and beta.
Subcellular location	Membrane; Single-pass type II membrane protein.
Sequence similarities	Belongs to the X(+)/potassium ATPases subunit beta family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Potassium
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro proton transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sodium:potassium-exchanging ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

294

Potassium-transporting ATPase subunit beta

PRO_0000219092

Regions

Topological domain

36

Cytoplasmic Potential

Transmembrane

21

Helical; Signal-anchor for type II membrane protein; Potential

Topological domain

237

Extracellular Potential

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Experimental info

Sequence conflict

1

T → P in BAB26635. Ref.3

Sequence conflict

2

TE → IK in BAB26654. Ref.3

Sequence conflict

1

Q → L in BAB26654. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

P50992 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: EAB8526C4C52431D
Show »

294

33,566

        10         20         30         40         50         60 
MAALQEKKSC SQRMAEFRHY CWNPDTGQML GRTPARWVWI SLYYAGFYVV MTGLFALCIY 

        70         80         90        100        110        120 
VLMQTIDPYT PDYQDQLKSP GVTLRPDVYG ERGLKISYNV SENSSWAGLT HTLHSFLAGY 

       130        140        150        160        170        180 
TPASQQDSIN CTSEKYFFQE SFAAPNHTKF SCKFTADMLQ NCSGLADPSF GFEEGKPCFI 

       190        200        210        220        230        240 
IKMNRIVKFL PSNNTAPRVD CTFQDDPQKP RKDTEPLQVE YYPPNGTFSL HYFPYYGKKA 

       250        260        270        280        290 
QPHYSNPLVA AKLLNVPKNM QVSIVCKILA DHVTFNNPHD PYEGKVEFKL TIQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The mouse gastric H,K-ATPase beta subunit. Gene structure and co-ordinate expression with the alpha subunit during ontogeny." Morley G.P., Callaghan J.M., Rose J.B., Toh H., Gleeson P.A., van Driel I.R. J. Biol. Chem. 267:1165-1174(1992) [PubMed: 1370459] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6. Tissue: Spleen.
[2]	"Structural organization and transcription of the mouse gastric H+, K(+)-ATPase beta subunit gene." Canfield V.A., Levenson R. Proc. Natl. Acad. Sci. U.S.A. 88:8247-8252(1991) [PubMed: 1654563] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Small intestine and Tongue.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M80251 , M80247, M80248, M80249, M80250 Genomic DNA. Translation: AAA37270.1. M64688 , M64685, M64686, M64687 Genomic DNA. Translation: AAA37269.1. AK008180 mRNA. Translation: BAB25514.1. AK009499 mRNA. Translation: BAB26326.1. AK009832 mRNA. Translation: BAB26530.1. Sequence problems. AK009994 mRNA. Translation: BAB26632.1. AK010003 mRNA. Translation: BAB26635.1. AK010030 mRNA. Translation: BAB26654.1. AK010049 mRNA. Translation: BAB26665.1.
IPI	IPI00124269.
PIR	A40993.
RefSeq	NP_033854.1. NM_009724.2.
UniGene	Mm.154039.
3D structure databases
ProteinModelPortal	P50992.
SMR	P50992. Positions 32-294.
ModBase	Search...
Protein-protein interaction databases
STRING	P50992.
Proteomic databases
PRIDE	P50992.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000033826; ENSMUSP00000033826; ENSMUSG00000031449.
GeneID	11945.
KEGG	mmu:11945.
Organism-specific databases
CTD	496.
MGI	MGI:88114. Atp4b.
Phylogenomic databases
eggNOG	roNOG06059.
HOGENOM	HBG446583.
HOVERGEN	HBG050603.
InParanoid	P50992.
OMA	MNRIVKF.
OrthoDB	EOG4TXBS9.
PhylomeDB	P50992.
Gene expression databases
ArrayExpress	P50992.
Bgee	P50992.
CleanEx	MM_ATP4B.
Genevestigator	P50992.
GermOnline	ENSMUSG00000031449. Mus musculus.
Family and domain databases
InterPro	IPR000402. ATPase_P-typ_cation-exchng_bsu. [Graphical view]
KO	K01543.
PANTHER	PTHR11523. ATPase_H_Na/K_b. 1 hit.
Pfam	PF00287. Na_K-ATPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITE	PS00390. ATPASE_NA_K_BETA_1. 1 hit. PS00391. ATPASE_NA_K_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	280053.
SOURCE	Search...

Entry information

Entry name

ATP4B_MOUSE

Accession

Primary (citable) accession number: P50992
Secondary accession number(s): Q9D6S3, Q9D6T2, Q9D6Y2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 16, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents