UniProtKB - P50990 (TCPQ_HUMAN)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
T-complex protein 1 subunit theta
Gene
CCT8
Organism
Homo sapiens (Human)
Status
Functioni
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.1 Publication
Caution
GO - Molecular functioni
- ATPase activity, coupled Source: ProtInc
- ATP binding Source: UniProtKB-KW
- cadherin binding Source: BHF-UCL
- protein binding involved in protein folding Source: GO_Central
- unfolded protein binding Source: GO_Central
GO - Biological processi
- 'de novo' protein folding Source: GO_Central
- binding of sperm to zona pellucida Source: Ensembl
- chaperone-mediated protein folding Source: GO_Central
- neutrophil degranulation Source: Reactome
- pore complex assembly Source: Ensembl
- positive regulation of establishment of protein localization to telomere Source: BHF-UCL
- positive regulation of protein localization to Cajal body Source: BHF-UCL
- positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
- positive regulation of telomere maintenance via telomerase Source: BHF-UCL
- protein folding Source: Reactome
- protein stabilization Source: BHF-UCL
- toxin transport Source: Ensembl
Keywordsi
Molecular function | Chaperone |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC R-HSA-390450 Folding of actin by CCT/TriC R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-5620922 BBSome-mediated cargo-targeting to cilium R-HSA-6798695 Neutrophil degranulation R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
Names & Taxonomyi
Protein namesi | Recommended name: T-complex protein 1 subunit thetaShort name: TCP-1-theta Alternative name(s): CCT-theta Chaperonin containing T-complex polypeptide 1 subunit 8 Renal carcinoma antigen NY-REN-15 |
Gene namesi | Name:CCT8 Synonyms:C21orf112, CCTQ, KIAA0002 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000156261.12 |
HGNCi | HGNC:1623 CCT8 |
MIMi | 617786 gene |
neXtProti | NX_P50990 |
Subcellular locationi
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 10694 |
OpenTargetsi | ENSG00000156261 |
PharmGKBi | PA26186 |
Polymorphism and mutation databases
BioMutai | CCT8 |
DMDMi | 9988062 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000128373 | 2 – 548 | T-complex protein 1 subunit thetaAdd BLAST | 547 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine1 Publication | 1 | |
Modified residuei | 23 | PhosphoserineCombined sources | 1 | |
Modified residuei | 30 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 162 | PhosphoserineCombined sources | 1 | |
Modified residuei | 213 | PhosphoserineCombined sources | 1 | |
Cross-linki | 224 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 254 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 260 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 269 | PhosphoserineCombined sources | 1 | |
Modified residuei | 317 | PhosphoserineCombined sources | 1 | |
Modified residuei | 318 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 400 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 459 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources | ||
Modified residuei | 466 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 505 | PhosphotyrosineCombined sources | 1 | |
Cross-linki | 534 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 537 | PhosphoserineCombined sources | 1 | |
Cross-linki | 539 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P50990 |
MaxQBi | P50990 |
PaxDbi | P50990 |
PeptideAtlasi | P50990 |
PRIDEi | P50990 |
TopDownProteomicsi | P50990-1 [P50990-1] |
2D gel databases
OGPi | P50990 |
REPRODUCTION-2DPAGEi | IPI00784090 P50990 |
PTM databases
iPTMneti | P50990 |
PhosphoSitePlusi | P50990 |
SwissPalmi | P50990 |
Expressioni
Gene expression databases
Bgeei | ENSG00000156261 |
CleanExi | HS_CCT8 |
ExpressionAtlasi | P50990 baseline and differential |
Genevisiblei | P50990 HS |
Organism-specific databases
HPAi | HPA018520 HPA021051 HPA029426 |
Interactioni
Subunit structurei
Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with DNAAF4 (By similarity).By similarity
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- protein binding involved in protein folding Source: GO_Central
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 115933199 interactors. |
CORUMi | P50990 |
DIPi | DIP-38124N |
IntActi | P50990 120 interactors. |
MINTi | P50990 |
STRINGi | 9606.ENSP00000286788 |
Structurei
3D structure databases
ProteinModelPortali | P50990 |
SMRi | P50990 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the TCP-1 chaperonin family.Curated
Phylogenomic databases
eggNOGi | KOG0362 Eukaryota ENOG410XPXR LUCA |
GeneTreei | ENSGT00550000074783 |
HOGENOMi | HOG000226734 |
HOVERGENi | HBG103107 |
InParanoidi | P50990 |
KOi | K09500 |
OMAi | WGLKYAV |
OrthoDBi | EOG091G05WZ |
PhylomeDBi | P50990 |
TreeFami | TF105699 |
Family and domain databases
CDDi | cd03341 TCP1_theta, 1 hit |
Gene3Di | 1.10.560.102 hits 3.30.260.102 hits 3.50.7.101 hit |
InterProi | View protein in InterPro IPR012721 Chap_CCT_theta IPR017998 Chaperone_TCP-1 IPR002194 Chaperonin_TCP-1_CS IPR002423 Cpn60/TCP-1 IPR027409 GroEL-like_apical_dom_sf IPR027413 GROEL-like_equatorial_sf IPR027410 TCP-1-like_intermed_sf |
PANTHERi | PTHR11353 PTHR11353, 1 hit |
Pfami | View protein in Pfam PF00118 Cpn60_TCP1, 1 hit |
PRINTSi | PR00304 TCOMPLEXTCP1 |
SUPFAMi | SSF48592 SSF48592, 2 hits SSF52029 SSF52029, 1 hit SSF54849 SSF54849, 2 hits |
TIGRFAMsi | TIGR02346 chap_CCT_theta, 1 hit |
PROSITEi | View protein in PROSITE PS00750 TCP1_1, 1 hit PS00751 TCP1_2, 1 hit PS00995 TCP1_3, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: P50990-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MALHVPKAPG FAQMLKEGAK HFSGLEEAVY RNIQACKELA QTTRTAYGPN
60 70 80 90 100
GMNKMVINHL EKLFVTNDAA TILRELEVQH PAAKMIVMAS HMQEQEVGDG
110 120 130 140 150
TNFVLVFAGA LLELAEELLR IGLSVSEVIE GYEIACRKAH EILPNLVCCS
160 170 180 190 200
AKNLRDIDEV SSLLRTSIMS KQYGNEVFLA KLIAQACVSI FPDSGHFNVD
210 220 230 240 250
NIRVCKILGS GISSSSVLHG MVFKKETEGD VTSVKDAKIA VYSCPFDGMI
260 270 280 290 300
TETKGTVLIK TAEELMNFSK GEENLMDAQV KAIADTGANV VVTGGKVADM
310 320 330 340 350
ALHYANKYNI MLVRLNSKWD LRRLCKTVGA TALPRLTPPV LEEMGHCDSV
360 370 380 390 400
YLSEVGDTQV VVFKHEKEDG AISTIVLRGS TDNLMDDIER AVDDGVNTFK
410 420 430 440 450
VLTRDKRLVP GGGATEIELA KQITSYGETC PGLEQYAIKK FAEAFEAIPR
460 470 480 490 500
ALAENSGVKA NEVISKLYAV HQEGNKNVGL DIEAEVPAVK DMLEAGILDT
510 520 530 540
YLGKYWAIKL ATNAAVTVLR VDQIIMAKPA GGPKPPSGKK DWDDDQND
Sequence cautioni
The sequence BAA02792 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 50 | N → K (PubMed:7584026).Curated | 1 | |
Sequence conflicti | 50 | N → K (PubMed:8590283).Curated | 1 | |
Sequence conflicti | 391 | A → V in BAA02792 (PubMed:7584026).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052270 | 4 | H → Q. Corresponds to variant dbSNP:rs16983693Ensembl. | 1 | |
Natural variantiVAR_052271 | 409 | V → I. Corresponds to variant dbSNP:rs8129954Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054691 | 1 – 78 | MALHV…RELEV → MDQMV in isoform 3. 1 PublicationAdd BLAST | 78 | |
Alternative sequenceiVSP_054692 | 1 – 20 | MALHV…KEGAK → M in isoform 2. 1 PublicationAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13627 mRNA Translation: BAA02792.2 Different initiation. D42052 Genomic DNA Translation: BAA07652.1 Sequence problems. AF129075 Genomic DNA No translation available. AK293705 mRNA Translation: BAG57138.1 AK298801 mRNA Translation: BAG60936.1 AL163249 Genomic DNA Translation: CAB90433.1 BC072001 mRNA Translation: AAH72001.1 BC095470 mRNA Translation: AAH95470.1 Z37163 mRNA Translation: CAA85520.1 |
CCDSi | CCDS33528.1 [P50990-1] CCDS68180.1 [P50990-3] CCDS68181.1 [P50990-2] |
PIRi | PC4021 |
RefSeqi | NP_001269836.1, NM_001282907.1 [P50990-2] NP_001269838.1, NM_001282909.1 [P50990-3] NP_006576.2, NM_006585.3 [P50990-1] |
UniGenei | Hs.125113 |
Genome annotation databases
Ensembli | ENST00000286788; ENSP00000286788; ENSG00000156261 [P50990-1] ENST00000540844; ENSP00000442730; ENSG00000156261 [P50990-3] ENST00000626972; ENSP00000486921; ENSG00000156261 [P50990-2] |
GeneIDi | 10694 |
KEGGi | hsa:10694 |
UCSCi | uc002ynb.5 human [P50990-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | TCPQ_HUMAN | |
Accessioni | P50990Primary (citable) accession number: P50990 Secondary accession number(s): A6NN54 Q4VBP8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 25, 2018 | |
This is version 183 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |