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Protein

Argininosuccinate lyase

Gene

argH

Organism
Streptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (assY), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (arlY), Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
OrganismiStreptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602)
Taxonomic identifieri443255 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001378321 – 473Argininosuccinate lyaseAdd BLAST473

Structurei

3D structure databases

ProteinModelPortaliP50988.
SMRiP50988.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7. Bacteria.
COG0165. LUCA.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 2 hits.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiView protein in InterPro
IPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
PANTHERiPTHR43814. PTHR43814. 1 hit.
PfamiView protein in Pfam
PF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiView protein in PROSITE
PS00163. FUMARATE_LYASES. 1 hit.

Sequencei

Sequence statusi: Complete.

P50988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNNGDVRL WGGRFADGPA DALARLSASV HFDWRLAPYD IAGSRAHARV
60 70 80 90 100
LNRAGLLTED ELTRMLAGLD RWPPMWRTLL HRTIADEDVH TALERGLLER
110 120 130 140 150
LGAELGGKLR AGRSRNDQVA TLFRMYLRTT PGSSGLIAEL QDALVGLAEA
160 170 180 190 200
HPEVAMPGRT HLQHAQPVLF AHHVLAHVQA LSRDAERLRQ WDARTAVSPY
210 220 230 240 250
GSGALAGSSL GLDPEAVAAD LGFEGGSAGN SIDGTASRDF VAEFAFITAM
260 270 280 290 300
AGINLSRLAE EIIIWNTKEF SFVTLHDAFS TGSSIMPQKK NPDIAELARG
310 320 330 340 350
KSGRLIGNLT GLLATLKALP LAYNRDLQED KEPVFDSCDQ LEVLLPAFTG
360 370 380 390 400
MVATLTVHRE RMEELAPAGF SLATDIAEWL VRQGVPFRVA HDVAGACVKE
410 420 430 440 450
CESAGIELHQ LTDEQFAAIS EHLTPEVRSV LTVRGALASR DGRGGTAPSA
460 470
VAVQLAEVKA DLAVQHAWAA RES
Length:473
Mass (Da):50,941
Last modified:January 31, 2002 - v2
Checksum:i44D15442BCC28E94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49111 Genomic DNA. Translation: CAA88927.2.
PIRiPC4128. S57660.

Similar proteinsi

Entry informationi

Entry nameiARLY_STRC2
AccessioniPrimary (citable) accession number: P50988
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 31, 2002
Last modified: February 28, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program