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Protein

Alpha-conotoxin PnIA

Gene
N/A
Organism
Conus pennaceus (Feathered cone) (Conus episcopus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian alpha-3-beta-2 > alpha-7 > alpha-3-beta-4 nAChRs.3 Publications

Miscellaneous

This toxin does not inhibit alpha-4-beta-2 nAChRs.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei10Important in inhibition of nAChR alpha-3-beta-2 subunit1 Publication1
Sitei11Important in inhibition of nAChR alpha-3-beta-2 and alpha-7 subunits1 Publication1

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin PnIA2 Publications
Short name:
Alpha-PnIA2 Publications
OrganismiConus pennaceus (Feathered cone) (Conus episcopus)
Taxonomic identifieri37335 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri75. Pni1.
51. PnIA.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi10A → L: 20-fold increase in inhibition of alpha-7, 7-10-fold decrease in inhibition of alpha-3-beta-2, and no change in inhibition of alpha-4-beta-2 nAChRs. 2 Publications1
Mutagenesisi11N → S: 7-fold decrease in inhibition of alpha-7 and 25-fold decrease in inhibition of alpha-3-beta-2 nAChRs. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000444621 – 16Alpha-conotoxin PnIA1 PublicationAdd BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 82 Publications
Disulfide bondi3 ↔ 162 Publications
Modified residuei15Sulfotyrosine1 Publication1
Modified residuei16Cysteine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond, Sulfation

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Interactioni

Protein-protein interaction databases

DIPiDIP-60493N.

Structurei

Secondary structure

116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Helixi6 – 11Combined sources6
Turni13 – 15Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PENX-ray1.10A1-16[»]
2BR8X-ray2.40F/G/H/I/J1-16[»]
SMRiP50984.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50984.

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/7 pattern.Curated

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR018072. Conotoxin_a-typ_CS.
PROSITEiView protein in PROSITE
PS60014. ALPHA_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P50984-1 [UniParc]FASTAAdd to basket

« Hide

        10 
GCCSLPPCAA NNPDYC
Length:16
Mass (Da):1,628
Last modified:October 1, 1996 - v1
Checksum:i05310FF95EC99005
GO

Sequence databases

PIRiA54877.

Cross-referencesi

Sequence databases

PIRiA54877.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PENX-ray1.10A1-16[»]
2BR8X-ray2.40F/G/H/I/J1-16[»]
SMRiP50984.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60493N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri75. Pni1.
51. PnIA.

Miscellaneous databases

EvolutionaryTraceiP50984.

Family and domain databases

InterProiView protein in InterPro
IPR018072. Conotoxin_a-typ_CS.
PROSITEiView protein in PROSITE
PS60014. ALPHA_CONOTOXIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCA1A_CONPE
AccessioniPrimary (citable) accession number: P50984
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 10, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.