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P50978

- LACG_STRMU

UniProt

P50978 - LACG_STRMU

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Protein
6-phospho-beta-galactosidase
Gene
lacG, SMU_1490
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei160 – 1601Proton donor By similarity
Active sitei375 – 3751Nucleophile By similarity

GO - Molecular functioni

  1. 6-phospho-beta-galactosidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: CACAO
  2. lactose catabolic process via tagatose-6-phosphate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-1399-MONOMER.
SABIO-RKP50978.
UniPathwayiUPA00542; UER00605.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phospho-beta-galactosidase (EC:3.2.1.85)
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase
Short name:
PGALase
P-beta-Gal
Short name:
PBG
Gene namesi
Name:lacG
Ordered Locus Names:SMU_1490
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4684686-phospho-beta-galactosidaseUniRule annotation
PRO_0000063893Add
BLAST

Proteomic databases

PRIDEiP50978.

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.1490.

Structurei

3D structure databases

ProteinModelPortaliP50978.
SMRiP50978. Positions 1-468.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2723.
KOiK01220.
OMAiNRWYLDP.
OrthoDBiEOG60658J.
PhylomeDBiP50978.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
HAMAPiMF_01574. LacG.
InterProiIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR01233. lacG. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50978-1 [UniParc]FASTAAdd to Basket

« Hide

MSKTLPKDFI FGGATAAYQA EGATHADGKG PVAWDKYLED NYWYTAEPAS    50
DFYHQYPVDL KLAEEFGVNG IRISIAWSRI FPKGYGAVNP KGLAFYHNLF 100
AECHKRHVEP FVTLHHFDTP EALHSNGDFL NRENIEHFVN YAEFCFKEFP 150
EVNYWTTFNE IGPIGDGQYL VGKFPPGIQY DLAKVFQSHH NMMVAHSKAV 200
KLFKDGGYSG EIGVVHALPT KYPYDPNNPA DIRAAELEDI IHNKFILDAT 250
YLGKYSEKTM EGVNHILAVN GGQLDLREED FAALEAAKDL NDFLGINYYM 300
SDWMRAFDGE TEITHNAKGE KGSSKYQIKG VGRREAPVNV PKTDWDWIIY 350
PQGLYDQIMR VKQDYPNYKK IYITENGLGY KDEFVNHTVY DDARIDYVKK 400
HLEVLSDAIA DGANVKGYFI WSLMDVFSWS NGYEKRYGLF YVDFDTQERY 450
PKKSAYWYKK LAETQIID 468
Length:468
Mass (Da):53,762
Last modified:November 28, 2002 - v2
Checksum:iFEDBDCE1E23D84F7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1501P → S in AAA16450. 1 Publication
Sequence conflicti300 – 3001M → I in AAA16450. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L18993 Unassigned DNA. Translation: AAA16450.1.
AE014133 Genomic DNA. Translation: AAN59144.1.
RefSeqiNP_721838.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN59144; AAN59144; SMU_1490.
GeneIDi1028734.
KEGGismu:SMU_1490.
PATRICi19664995. VBIStrMut61772_1326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L18993 Unassigned DNA. Translation: AAA16450.1 .
AE014133 Genomic DNA. Translation: AAN59144.1 .
RefSeqi NP_721838.1. NC_004350.2.

3D structure databases

ProteinModelPortali P50978.
SMRi P50978. Positions 1-468.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.1490.

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Proteomic databases

PRIDEi P50978.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN59144 ; AAN59144 ; SMU_1490 .
GeneIDi 1028734.
KEGGi smu:SMU_1490.
PATRICi 19664995. VBIStrMut61772_1326.

Phylogenomic databases

eggNOGi COG2723.
KOi K01220.
OMAi NRWYLDP.
OrthoDBi EOG60658J.
PhylomeDBi P50978.

Enzyme and pathway databases

UniPathwayi UPA00542 ; UER00605 .
BioCyci SMUT210007:GC7Z-1399-MONOMER.
SABIO-RK P50978.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
HAMAPi MF_01574. LacG.
InterProi IPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR01233. lacG. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterization and nucleotide sequence of the Streptococcus mutans lactose-specific enzyme II (lacE) gene of the PTS and the phospho-beta-galactosidase (lacG) gene."
    Honeyman A.L., Curtiss R. III
    J. Gen. Microbiol. 139:2685-2694(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 700611 / UA130 / Serotype c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiLACG_STRMU
AccessioniPrimary (citable) accession number: P50978
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 28, 2002
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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