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P50977

- LACG_LACAI

UniProt

P50977 - LACG_LACAI

Protein

6-phospho-beta-galactosidase

Gene

lacG

Organism
Lactobacillus acidophilus
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei160 – 1601Proton donorUniRule annotation
    Active sitei375 – 3751NucleophileUniRule annotation

    GO - Molecular functioni

    1. 6-phospho-beta-galactosidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lactose catabolic process via tagatose-6-phosphate Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00542; UER00605.

    Protein family/group databases

    CAZyiGH1. Glycoside Hydrolase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phospho-beta-galactosidaseUniRule annotation (EC:3.2.1.85UniRule annotation)
    Alternative name(s):
    Beta-D-phosphogalactoside galactohydrolaseUniRule annotation
    Short name:
    PGALaseUniRule annotation
    P-beta-GalUniRule annotation
    Short name:
    PBGUniRule annotation
    Gene namesi
    Name:lacGUniRule annotation
    Synonyms:pbg
    OrganismiLactobacillus acidophilus
    Taxonomic identifieri1579 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4734736-phospho-beta-galactosidasePRO_0000063881Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP50977.
    SMRiP50977. Positions 1-473.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 1 family.UniRule annotation

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    HAMAPiMF_01574. LacG.
    InterProiIPR005928. 6P-beta-galactosidase.
    IPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10353. PTHR10353. 1 hit.
    PfamiPF00232. Glyco_hydro_1. 1 hit.
    [Graphical view]
    PRINTSiPR00131. GLHYDRLASE1.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    TIGRFAMsiTIGR01233. lacG. 1 hit.
    PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50977-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKTLPKDFI FGGATAAYQA EGATKTDGKG RVAWDKFLEE NFWYKGDPAS    50
    DFYHNYVEDL ELAEKFGGNV IRISIAWSRI FPNGDGEVKP NGVDFYHKLF 100
    AECDARHVEP FVTLHHFDTP EGLHEDGDFL THEKMDDFVE YADYCFKEFP 150
    EVKYWITINE IRSVAVDQYI IGNFPPADTF GFDKMFQTHH NQMVGHARAV 200
    KLFKHDGSKG EIGIVHALQT NYPFNESNPA DIGAAELEDL LDNKFLVDGT 250
    FVGKYPQETM EAVKDILAAN HGGEFNIEDE FKAIDAAKDV QDFVGVDYYL 300
    SEWMRAYDGK SEITHNGTGD KGTSKVQVKG VGEEKLPDGI ETTDWDWLIY 350
    PQGLYDKIMR VKNDYPNIHK VYITENGIGF KDTVPDNEET DKTVHDDARI 400
    DYVKQHLEVI ADAIADGANV KGYFIWSLMD VFTWTNGYTK RYGLFYVDFD 450
    TQDRYPSKTA DWFKNLAETH IIE 473
    Length:473
    Mass (Da):54,009
    Last modified:October 1, 1996 - v1
    Checksum:iA7D17EADEC19246A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D37882 Genomic DNA. Translation: BAA07122.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D37882 Genomic DNA. Translation: BAA07122.1 .

    3D structure databases

    ProteinModelPortali P50977.
    SMRi P50977. Positions 1-473.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH1. Glycoside Hydrolase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00542 ; UER00605 .

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    HAMAPi MF_01574. LacG.
    InterProi IPR005928. 6P-beta-galactosidase.
    IPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10353. PTHR10353. 1 hit.
    Pfami PF00232. Glyco_hydro_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00131. GLHYDRLASE1.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    TIGRFAMsi TIGR01233. lacG. 1 hit.
    PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and structural analysis of the phospho-beta-galactosidase gene from Lactobacillus acidophilus."
      Kanatani K., Oshimura M.
      J. Ferment. Bioeng. 78:123-129(1994)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LTF42.

    Entry informationi

    Entry nameiLACG_LACAI
    AccessioniPrimary (citable) accession number: P50977
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3