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P50977

- LACG_LACAI

UniProt

P50977 - LACG_LACAI

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Protein
6-phospho-beta-galactosidase
Gene
lacG, pbg
Organism
Lactobacillus acidophilus
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei160 – 1601Proton donor By similarity
Active sitei375 – 3751Nucleophile By similarity

GO - Molecular functioni

  1. 6-phospho-beta-galactosidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactose catabolic process via tagatose-6-phosphate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00542; UER00605.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phospho-beta-galactosidase (EC:3.2.1.85)
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase
Short name:
PGALase
P-beta-Gal
Short name:
PBG
Gene namesi
Name:lacG
Synonyms:pbg
OrganismiLactobacillus acidophilus
Taxonomic identifieri1579 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4734736-phospho-beta-galactosidaseUniRule annotation
PRO_0000063881Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP50977.
SMRiP50977. Positions 1-473.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
HAMAPiMF_01574. LacG.
InterProiIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR01233. lacG. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50977-1 [UniParc]FASTAAdd to Basket

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MTKTLPKDFI FGGATAAYQA EGATKTDGKG RVAWDKFLEE NFWYKGDPAS    50
DFYHNYVEDL ELAEKFGGNV IRISIAWSRI FPNGDGEVKP NGVDFYHKLF 100
AECDARHVEP FVTLHHFDTP EGLHEDGDFL THEKMDDFVE YADYCFKEFP 150
EVKYWITINE IRSVAVDQYI IGNFPPADTF GFDKMFQTHH NQMVGHARAV 200
KLFKHDGSKG EIGIVHALQT NYPFNESNPA DIGAAELEDL LDNKFLVDGT 250
FVGKYPQETM EAVKDILAAN HGGEFNIEDE FKAIDAAKDV QDFVGVDYYL 300
SEWMRAYDGK SEITHNGTGD KGTSKVQVKG VGEEKLPDGI ETTDWDWLIY 350
PQGLYDKIMR VKNDYPNIHK VYITENGIGF KDTVPDNEET DKTVHDDARI 400
DYVKQHLEVI ADAIADGANV KGYFIWSLMD VFTWTNGYTK RYGLFYVDFD 450
TQDRYPSKTA DWFKNLAETH IIE 473
Length:473
Mass (Da):54,009
Last modified:October 1, 1996 - v1
Checksum:iA7D17EADEC19246A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D37882 Genomic DNA. Translation: BAA07122.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D37882 Genomic DNA. Translation: BAA07122.1 .

3D structure databases

ProteinModelPortali P50977.
SMRi P50977. Positions 1-473.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00542 ; UER00605 .

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
HAMAPi MF_01574. LacG.
InterProi IPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR01233. lacG. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and structural analysis of the phospho-beta-galactosidase gene from Lactobacillus acidophilus."
    Kanatani K., Oshimura M.
    J. Ferment. Bioeng. 78:123-129(1994)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LTF42.

Entry informationi

Entry nameiLACG_LACAI
AccessioniPrimary (citable) accession number: P50977
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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